MTHFR 677C>T
Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters
... One blood sample was drawn at some point during preg- nancy. These whole blood samples were immediately put on ice and centrifuged within 12 h at 2,000 rpm for 10 min. Genomic DNA was isolated from buffy coat with Qiagen ...
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MTHFR 677C T and 1298A C Gene Polymorphisms and Its Relation to Levels of Homocysteine, Folate Vitamin B 12
... The enzyme 5, 10 methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in folate and homocysteine metabolism. Folate is implicated in carcinogenesis due to its role in DNA methylation, repair and ...
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Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C >T polymorphism
... the MTHFR 677 TT ...the MTHFR 677C3 T polymorphism carries an increased risk of CHD in Europe but not in North America where riboflavin fortifica- tion has existed for ⬎ 50 ...
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Association of Methylenetetrahydrofolate Reductase (MTHFR 677C>T and 1298A>C) Polymorphisms and Haplotypes with Silent Brain Infarction and Homocysteine Levels in a Korean Population
... the MTHFR 677C>T and 1298A>C gene polymorphisms are associated with SBI and plasma homocysteine concentration in a Korean ...the MTHFR gene was carried ...the MTHFR 677TT genotype ...
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The TT Genotype of the MTHFR 677C>T Polymorphism Increases Susceptibility to Premature Coronary Artery Disease in Interaction with Some of the Traditional Risk Factors
... of 677C>T polymorphism of MTHFR gene and some traditional risk factors ...The MTHFR 677C>T polymorphism was genotyped with Polymerase Chain Reaction-Restric- tion Fragment ...
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Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C -> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels
... We included consecutive patients 18±49 years of age who were hospitalized with a ®rst MI to one of the 16 participating centers (see Appendix) in the Netherlands between January 1990 and October 1995. The patients were ...
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Polymorphism study of MTHFR 677C?T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq Muthanna A. Thabit| Gaylany H. Abdullah | Khalid F. AL-Rawi1
... Oxidative stress (OS) is caused by an imbalance between pro-oxidants and antioxidants, excessive amounts of reactive oxygen species (ROS) generation, nevertheless, may curb the body's characteristic antioxidant ...
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Association of Methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphisms with Ovarian Malignancy in women of Northern India
... All the values were calculated as Mean ± SD (standard deviation). Correlation of total homocysteine with other biological parameters was calculated by Person’s correlation. Mean values obtained for the different ...
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Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein 1
... prised equal numbers of each MTHFR 677C N T genotype class (i.e. CC, CT, and TT), matched by sex and smoking status. The mean age for men was 22.4 and for women it was 23.1 years. The mean MCP-1 ...
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No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation
... Heikkinen T, Broeks A, Veer LJ, van der Schoot CE, Guenel P, Truong T, Laurent-Puig P, Menegaux F, Marme F, Schneeweiss A, Sohn C, Burwinkel B, Zamora MP, Perez JI, Pita G, Alonso MR, Cox A, Brock IW, Cross ...
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Original Article MTHFR genetic polymorphism increases the risk of preterm delivery
... in MTHFR gene, we discovered that haplotype T-A had a higher distribution in cases, which indicated that susceptible haplotype T-A was the candidate factor for premature ...of MTHFR C677T ...
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Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators
... the MTHFR gene promoter and biochemical, inflamma- tory and oxidative stress markers in individuals with type 2 diabetes (T2DM) who have been diagnosed for 5–10 years with or without diabetic retinopathy (DR) and ...
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Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population
... The MTHFR C677T polymorphism influences homo- cysteine metabolism and hyperhomocysteinemia has been reported in glaucoma patients ...The MTHFR C677T polymorphism causes an alanine > valine amino acid ...
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MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
... 24. Ramírez-Pacheco A, Moreno-Guerrero S, Alamillo I, Medina-Sanson A, Lopez B, Moreno-Galvan M. Mexican childhood acute lymphoblastic leukemia: a pilot study of the MDR1 and MTHFR gene polymorphisms and their ...
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Methotrexate effect on biochemical indices of psoriasis patients depends on MTHFR gene polymorphism
... between MthFR gene polymorphisms (OMIM 607093) responses to MTX treatment and adverse reactions to MTX was discove red in patients with rheumatoid arthritis ...and MthFR genes and either MTX efficacy or ...
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Antiepileptic drug induced psychosis associated with MTHFR C677T: a case report
... Folate, riboflavin, pyridoxine, and cobalamin deficien- cies, as observed in our patient, can cause hyperhomo- cysteinemia because these vitamins are involved in folate and homocysteine metabolism [16]. Elevation of MCV ...
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Original Article Association between MTHFR polymorphisms and ankylosing spondylitis risk
... the MTHFR protein activa- ...between MTHFR poly- morphisms and AS ...between MTHFR polymrphisms (C677T and A1298C) and AS occurrence was detected in this case-control ...
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Association Between MTHFR Genetic Variants and Multiple Sclerosis in a Southern Iranian Population
... of MTHFR 677 and 1298 genotypes on MS risk, we analyzed the relationship between combined MTHFR SNPs at these loci and MS ...influence MTHFR activity and plasma homocysteine concentrations (15, 35), ...
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Original Article Tagging functional SNPs rs191876689 in MTHFR decrease risk of ischemic stroke
... ROS generation is enhanced and can lead to damage to various types of cells, including brain endothelial cells, leading to formation of thrombosis and loss of brain function. Among the ROS signaling, MTHFR is an ...
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Methylenetetrahydrofolate Reductase (MTHFR) Gene Mutations in Patients with Idiopathic Scoliosis: A Clinical Chart Review
... that MTHFR variants are causative for sco- liosis, given that a notable minority of non-scoliotic patients also carry these po- ...the MTHFR genetic variation of the A1298C allele in patients with ...
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