mTOR/S6K
Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells
... stimulating mTOR-S6K-S6 activ- ...of mTOR [2, 4]. Mechan- istically, STAT6 suppresses mTOR and downstream S6K and S6 phosphorylation through direct interactions with ...
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Hypoxia Induces Permeability and Giant Cell Responses of Andes Virus-Infected Pulmonary Endothelial Cells by Activating the mTOR-S6K Signaling Pathway
... activate mTOR, while rapamycin inhibits mTOR-directed giant cell and VEGF A-directed permeability re- sponses in mice and hamsters (43–46, ...of mTOR activation, and giant cells are caused by ...
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Original Article Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling
... Abstract: Oleanolic acid has significant pharmacological activities, such as anti-tumor, regulating blood sugar level and liver protection, which are more effective compared with free aglyconeoleanolic acid. However, it ...
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Original Article LC3B and ph-S6K are both expressed in epithelioid and classic renal angiomyolipoma: a rationale tissue-based evidence for combining use of autophagic and mTOR targeted drugs
... quantitative S6K/Ponceaus ...and mTOR processes may be designed in clinical trials, when enrolling patients affected by tumours in tuberous sclerosis or angiomyolipoma at risk of ...
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PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT/mTOR pathway
... units/0.1 ml, i.v. injection in one day after surgery, and repeated in 2 weeks after surgery), and PKD siRNA plus 3-methyladenine (3-MA, an autophagy inhibitor, 20 mg/kg/day, i.p.), respectively. Four weeks after TAC ...
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Mechanistically distinct cancer associated mTOR activation clusters predict sensitivity to rapamycin
... toward S6K in vitro, which is also reflected by the different tumor growth rates in ...gested mTOR mutations could increase mTORC2 activities, but the effects were very subtle (83), which is largely in line ...
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MicroRNA-145 inhibits the activation of the mTOR signaling pathway to suppress the proliferation and invasion of invasive pituitary adenoma cells by targeting AKT3 in vivo and in vitro
... sample was collected and separated by sodium dodecyl sul- fate polyacrylamide gel electrophoresis (SDS-PAGE); after which the upper sample was transferred onto polyvinylidene fluoride (PVDF) membrane and blocked for 1 h ...
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Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110 inhibition
... of mTOR downstream targets p70-S6K and rpS6 (Figure 2A), suggesting that PIM kinase activity is required for phosphorylation of mTORC1 targets in GBM ...enhance mTOR activity albeit through different ...
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S6 kinase 1 is required for rapamycin sensitive liver proliferation after mouse hepatectomy
... rapamycin-sensitive mTOR substrates that are involved in cell proliferation and tissue regeneration after partial hepatectomy in ...of S6K-null ...high mTOR complex 1 activity and cyclin D1 ...
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The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis
... Sigma), mTOR (2972), mTOR S2448 (2971), S6K (9202), S6K T389 (9206), S6 (2317), S6 S235/36 (4858), S6 240/44 (4838), TSC2 (3635), 4E-BP1 (9644), 4E-BP1 T37/46 (2855), 4E-BP1 S65 (9451), 4E-BP1 ...
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The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats
... / mTOR pathway, so that measuring the expression of the Akt and mTOR genes together with structural changes in the heart can provide useful information on the growth and improvement of cardiac conditions as ...
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Failure to ubiquitinate c Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease
... Inhibition of Akt and S6K activity in vivo by c-Met inhibitor. Immunohistochemical staining (A) and Western blot analysis (B) of phospho-Akt and phospho-S6K in vehicle- and c-Met inhibitor–treated embryonic ...
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Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase
... of mTOR complexes with the catalytic mTOR inhibitor OSI-027 and of the p110α subunit of PI3K with the specific inhibitor BYL- 719 results in efficient suppression of effector pathways and enhanced induction ...
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Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models.
... Activation of the PI3K/mTOR pathway has been shown to be correlated with resistance to chemotherapy in ovarian cancer. We aimed to investigate the effects of combining inhibition of mTORC1 and 2 using the ...
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Activation of hypothalamic S6 kinase mediates diet induced hepatic insulin resistance in rats
... of S6K in the mediobasal hypothalamus (MBH). Constitutive activation of S6K in the MBH mimicked the effect of the HFD in normal chow–fed animals, while suppression of S6K by overexpression of ...
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17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway
... effectors S6K and S6 induced by 15 min in MCF-7 cells and further proved that Akt was activated via nongenomic membrane-activated estrogen receptor (ER) signaling in MCF-7 cells, rather than the classical genomic ...
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Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation
... elon), anti-PI(4,5)P2 (Echelon), anti-PI4KB (7, BD Biosciences), anti- PIP5K1A (polyclonal, Proteintech), anti-PIP5K1B (polyclonal, Protein- tech), anti-PLCγ1 (polyclonal, Cell Signaling Technology), anti-S6K ...
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PRAS40 Regulates Protein Synthesis and Cell Cycle in C2C12 Myoblasts
... Cell cycle progression is linked to cell size, and typically cells must attain a cer- tain size before they replicate and divide. However, exceptions to this norm may be observed under artificial (for example, ...
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PubMedCentral-PMC4711922.pdf
... and mTOR signaling in pancreatic cancer cell ...of mTOR, p70S6K, and 4E-BP1 at various time points after treatment with 5 mM ..., mTOR, p70S6K, and 4E-BP1 relative to total levels shown in (B) and ...
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Original Article Expression of phosphorylated mTOR and its clinical significances in small cell lung cancer
... We found that p-mTOR expression is signifi- cantly higher in limited-stage than extended- stage SCLCs, and that lymph node metastasis was more frequently detected in the low p-mTOR expression group, as ...
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