Multi-epitope
Discovery of novel targets for multi epitope vaccines: Screening of HIV 1 genomes using association rule mining
... develop multi-epitope vaccines, including (a) the generation of tetramer epitope vaccines with epitopes being chosen based on the pres- ence of principal neutralizing determinant [12], (b) the ...
12
Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii
... plus multi-epitope polypeptide immunogenicity in ...plus multi-epitope polypeptide or polypeptides alone were significantly reduced compared with the mice immunized with control empty vector ...
19
Tumor heterogeneity as a rationale for a multi-epitope approach in an autologous renal cell cancer tumor vaccine
... (multi- epitope approach) seems reasonable for the adjuvant vac- cination of patients suffering from renal ...A multi- epitope approach could therefore be appropriate in the fight against ...
15
Original Article Immunological response of recombinant H. pylori multi-epitope vaccine with different vaccination strategies
... pylori multi-epitope antigen (rIB) with cholera toxin subunit B (rCTB) as the intramolecular/extramolecular adjuvant though different immunization routes in a Helicobacter pylori infected mouse ...
8
Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii
... a multi-epitope DNA prime-protein boost also appeared to drive a more functionally divergent T-cell response ...a multi-epitope DNA prime-protein boost resulted in four times more IFN-γ + - ...
46
Design and evaluation of a recombinant multi epitope antigen for serodiagnosis of Toxoplasma gondii infection in humans
... Background: Serological investigation remains the primary approach to achieve satisfactory results in Toxoplasma gondii identification. However, the accuracy of the native antigen used in the current diagnostic kits has ...
5
Design and evaluation of a multi epitope assembly Peptide (MEAP) against herpes simplex virus type 2 infection in BALB/c mice
... In addition, Cell-mediated immunity plays an impor- tant role in efficient protection. The results of cytokine assay and CTL activity indicated that CTL activity and the level of Th2-type cytokines (IL-4) produced in the ...
10
Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach
... the multi-epitope vaccines (MEVs) are composed of cytotoxic T lymphocyte (CTL) and helper T lymphocyte (HTL) epitopes, screened form thirteen differ- ent proteins of ...linear epitope regions, B-cell ...
15
Evaluation of recombinant multi epitope proteins for diagnosis of goat schistosomiasis by enzyme linked immunosorbent assay
... recombinant multi- epitope proteins and SEA were applied as diagnostic an- tigens to detect goat ...recombinant multi-epitope proteins, except for rBSjPGM-BSjRAD23-1, was higher than those of ...
11
A novel multi epitope recombined protein for diagnosis of human brucellosis
... different epitope prediction software pro- grams (ABCPred, BepiPred, and COBEPro) were used to predict the most immunogenic linear B-cell epitopes in this ...
8
Immunogenicity of Multi-epitope Vaccine Candidate against Toxoplasma gondii Infection in BALB/c Mice
... a multi- antigenic vaccine expressing different stages of the parasite life cycle was shown to induce a broader and longer lasting protection ...express multi-antigenic determinant of ...
10
Affinity Purification and Comparative Biosensor
... serum samples bound to Cit-vimentin and to the multi-epitope peptide, only 30-60 % of RA sera 299. reacted with citrulline containing collagen II, fibrin β and filaggrin19 peptides on[r] ...
17
Identification of a novel linear B cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates
... linear epitope by Pepscan analysis Twenty-three overlapping synthetic peptides (15aa) cor- responding to the coding sequence of recombinant N protein (aa 401–523) were synthesized (Sangon, China) to map the mab ...
9
Study of B cell epitope conserved region of the Zika virus envelope glycoprotein to develop multi-strain vaccine
... of multi-strain ZIKV ...cell epitope conserved region of ZIKV envelope glycoprotein through an intensive in silico ...cell epitope was identified using the immune epitope database (IEDB) web ...
6
In Silico Characterization of Epitopes from Human Rotavirus VP7 Genotype G9 Design for Vaccine Development
... selected epitope for B and T cells epitope showed no N-link Glycosylated Sites, only O-linked Glycosylated Sites predicted at positions of 80 and 87the VP7 (G9) ...selected epitope (87-100aa) was ...
7
Proteomic Analysis and Immunogenicity of Mannheimia haemolytica Vesicles
... immunodominant epitope of PlpE and the neutralizing epitope of LKT (11) stimulated antibodies with po- tent complement-mediated cell killing and LKT-neutralizing ac- tivities, whereas cattle vaccinated with ...
6
Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes
... cell epitope from the T cell receptor reper- toire is not determined by whether it is the chondroitin sulfate or keratan sulfate side chains that are removed (Table II, ...inhibiting epitope recognition by ...
10
Distinct Evolutionary Pressures Underlie Diversity in Simian Immunodeficiency Virus and Human Immunodeficiency Virus Lineages
... Extended sampling of SIVsmm diversity. Previous studies of SIVsmm diversity and evolution (2, 93) suggested that the levels of within-group sequence diversity were roughly comparable be- tween SIVsmm and HIV-1 M group ...
15
IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS 1
... develop an effective HIV vaccine and meet the challenge of new and re-emerging pathogens. This can be easily achieved with the help of reverse vaccinology that uses the whole genome of the pathogen for the prediction of ...
25
Contribution of T-Cell Receptor Repertoire Breadth to the Dominance of Epitope-Specific CD8+ T-Lymphocyte Responses
... Subdominant epitope-specific populations have a restricted V  ...subdominant epitope-specific CD8 ⫹ T lympho- cytes of a cohort of chronically infected Mamu-A*01 ⫹ and Mamu- A*02 ⫹ rhesus ...p199RY ...
9