multipotent progenitors
Zbtb1 prevents default myeloid differentiation of lymphoid- primed multipotent progenitors
... immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone marrow ...lymphoid-primed multipotent progenitors (LMPPs) ...
11
Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors
... HSC Multipotent Progenitors (MPPs) into CLP and CMP and introduce two concepts from population biology into stem cell ...the Multipotent Progenitor Commitment Response (MPCR) which is the probability ...
14
Single cell origin of multilineage colonies in culture Evidence that differentiation of multipotent progenitors and restriction of proliferative potential of monopotent progenitors are stochastic processes
... Grunwald-Giemsa stained preparation. Of 150 single candidate cells replated, 63 produced colonies. The incidences of single lineage colonies included 19 erythroid, 17 monocyte- macrophage, and 9 eosinophil colonies. ...
6
A clonal analysis of neural progenitors during axolotl spinal cord regeneration reveals evidence for both spatially restricted and multipotent progenitors
... proliferating progenitors along the A/P ...was multipotent; producing daughter cells that would contribute to multiple neuronal cell ...neural progenitors in the regenerating spinal cord are ...
11
Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis
... Many organs in the human body, such as the lung, kidney and mammary gland, develop in the embryo from simple epithelial sheets that fold, branch and ramify into complex tubular structures. Tubular organs arise from ...
10
Notch and Nodal control forkhead factor expression in the specification of multipotent progenitors in sea urchin
... foxY is the first known transcription factor to be specifically expressed in CPC progenitors downstream of Notch signaling. To test whether it is a potential regulator of other CPC genes we knocked down foxY ...
11
Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony forming assay
... Targeted disruption of Wnt4 results in kidney agenesis and impairs mesenchymal-to-epithelial transformation (Stark et al., 1994), and co-culture with 3T3Wnt4 induces tubulogenesis in the mesenchyme rudiment in organ ...
11
Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential
... Results: There was no difference in the outgrowth potential of the SP vs. NSP cells when 5,000 cells per fat pad were transplanted. However, individual clones derived from single cells sorted from either SP or NSP ...
13
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
... endocrine progenitors. Consistent with the idea that such progenitors exist, centroacinar or terminal duct cells, which express Sox9 and lie at the interface of acini and small ducts, were found to be ...
13
Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells
... isolating multipotent progenitors with positive selec- tion markers such as stem cell antigen 1 [11] and neuron-glial antigen 2 ...of multipotent progenitors by negative selection [16]; 2) ...
14
Evidence for a stepwise program of extrathymic T cell development within the human tonsil
... The development of a broad repertoire of T cells, which is essential for effective immune function, occurs in the thymus. Although some data suggest that T cell development can occur extrathymically, many researchers ...
14
Cellular and molecular mechanisms in kidney fibrosis
... Can monocytes undergo a profound phenotypic change, or is there a minor circulating progenitor or fibrocyte recruited to the kidney? Studies from different labs have led to different conclu- sions. One group of studies ...
9
The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors
... of progenitors and in lineage specification during early ...neural progenitors to switch to a quiescent and eventually differentiating state in ...neuronal progenitors appears to be exerted by Gata2 ...
11
Specialized progenitors and regeneration
... transcription factors distinguish the pigment cup cell lineage (dlx and sp6-9) and the photoreceptor eye lineage (otxA). Specialized neoblasts produce particular differentiated cells. Modified from Lapan and Reddien ...
7
Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2 5 function
... demonstrated that zebrafish populations individually positive for gata4, nkx2.5 and ltbp3 trace to all three lineages in vivo. However, based on these results alone, and in the absence of a zebrafish clonal assay, we ...
11
Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
... erythroid progenitors and blood reticulocytes and was associated with accelerated red cell recovery in myelosuppressed ...erythroid progenitors respond to TOP and that this newly cloned cytokine, critical ...
6
Defining developmental diversification of diencephalon neurons through single cell gene expression profiling
... proliferating progenitors to postmitotic cells ...from progenitors to postmitotic cells ...dividing progenitors have higher gene counts than their ...
13
A Sox9/Fgf feed forward loop maintains pancreatic organ identity
... pancreatic progenitors convert to an hepatic fate upon perturbations of the Sox9/Fgf10/Fgfr2b loop, but pancreatic and hepatic differentiation is initiated in parallel within the ...some progenitors undergo ...
10
Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell autonomous requirements for Lmx1b in dorsal ventral limb patterning
... The LIM-homeodomain transcription factor Lmx1b is both necessary and sufficient to instruct dorsal fates during limb development (Chen et al., 1998; Riddle et al., 1995; Vogel et al., 1995). Our studies provide evidence ...
8
Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
... New granule cells are continuously generated in the dentate gyrus of the adult hippocampus. During granule cell maturation, the mechanisms that differentiate new cells not only describe the degree of cell ...
14