Mutations in the reverse transcriptase
Mutations That Abrogate Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimerization Affect Maturation of the Reverse Transcriptase Heterodimer
... of mutations that abrogate human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) dimerization on virus replication is not known, as mutations shown previously to inhibit RT ...
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Telomerase reverse transcriptase (TERT) promoter mutations in Korean melanoma patients
... Telomerase reverse transcriptase (TERT) is the reverse transcriptase component of the telomeric complex, which synthesizes terminal DNA to protect chromosomal ends and to maintain genomic ...
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Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates
... “Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas – Clinicopathological correlates” of the candidate Shailaja Balakumar with registration Number 201513356 for the ...
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Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment
... Objective: Replication of HIV-1 after cell entry is es- sentially dependent on the reverse transcriptase (Rt). antiretroviral drugs impairing the function of the Rt currently aim at the polymerase subunit. ...
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Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... example, mutations that emerge in vivo in response to 3TC, ddI, PFA, or certain nonnucleoside reverse transcriptase inhibitors can confer hypersusceptibility to AZT and “resensitize” AZT-resistant ...
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Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance.
... Received 1 August 1994/Accepted 7 November 1994 Genetic recombination between viral genomes has been shown to contribute to the generation of genetic diversity during retrovirus infections. The role of recombination in ...
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Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... (HIV-1) reverse transcriptase (RT) has been extensively studied, there are still significant questions about the effects of mutations on the maturation and stability of ...point mutations we ...
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Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis
... telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still ...promoter mutations tended to present in aggressive ...
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Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... to reverse transcriptase inhibitors is a very complex phenomenon, it is conceivable that more mutations (and associations of mutations) than currently known are in- volved in the development ...
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Analysis of resistant mutations in reverse transcriptase domain of hepatitis B virus from patients from Islamabad, Pakistan
... resistance mutations in hepatitis B virus (HBV) reverse transcriptase (RT) domain from non-responder Pakistani ...resistant mutations in the RT domain. Results: Resistant mutations were ...
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Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.
... in reverse transcription, we generated a panel of mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase based on sequence alignments and the crystal structures ...
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Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi
... Conclusion: Despite the presence of DRMs to drugs included in the current regimen in some individuals, and immune failure in three, no signs of clinical failure were seen during this study. This cohort will continue to ...
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Molecular Mechanism of Antagonism between the Y181C and E138K Mutations in HIV-1 Reverse Transcriptase
... M184I/V mutations, leading to high-level resis- tance to both 3TC and FTC (47, ...two mutations in tandem caused decreased dNTP binding and that the presence of E138K decreased levels of resistance con- ...
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Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
... of mutations in the 153-nt sequence of lacZ ␣ were detailed in 2-by-153 tables for each pairwise comparison of the lacZ ␣ mutational ...of mutations into smaller 2-by-n tables for which n was considerably ...
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Mn2+ Suppressor Mutations and Biochemical Communication between Ty1 Reverse Transcriptase and RNase H Domains
... suppressor mutations in the RH domain somehow alter the affinity of one or both of these sites in the polymerase domain to increase the affinity for Mg 2⫹ or lower the affinity for Mn 2⫹ ...
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Mutations in the gag gene of Moloney murine leukemia virus: effects on production of virions and reverse transcriptase.
... In addition, analysis of the supernatants from the cultures transfected with the mutants showed no detectable reverse transcriptase activity, where- as cells transfected with the wild-ty[r] ...
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Increasing Prevalence of Synonymous Mutations K65K and K66K in HIV-1. Subtype B Reverse Transcriptase
... We next analysed the relative contribution of K66K compared to K65K in addition to the evolution of silent substitutions (i.e. AAAAAG) at 20 other consensus lysine residues across HIV-1 RT in antiretroviral drug naïve ...
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Reduced Fitness in Cell Culture of HIV-1 with Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Mutations Correlates with Relative Levels of Reverse Transcriptase Content and RNase H Activity in Virions
... In conclusion, our current results indicate that the reduction of fitness in viruses with NNRTI resistance mutations is based on either of two possible mechanisms. We had previously re- ported that the mutant RTs ...
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Requirement for Integrase during Reverse Transcription of Human Immunodeficiency Virus Type 1 and the Effect of Cysteine Mutations of Integrase on Its Interactions with Reverse Transcriptase
... IN mutations that fail to support reverse transcription in vivo are incapable of interacting with RT in ...of reverse transcrip- tion, retain the ability to physically interact with ...of ...
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Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance
... The K65R mutation is located in the fingers domain of RT and its effect on reduction of NRTI incorporation and reduced excision is probably due to an increased rigidity of the active site and effective trapping of the ...
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