myeloid cell leukemia-1
Myeloid Cell Leukemia-1 Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome
... Myeloid cell leukemia-1 (Mcl-1) is encoded by the Mcl-1 ...isoform 1 (longer gene product) and isoform 2 (shorter gene product) ...Isoform 1, an important ...
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Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1
... protein myeloid cell leukemia 1 (Mcl1) was initially identified from the upregulation of its gene during myeloid leukemia cell differentiation (Kozopas et ...to ...
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Novel Insights into the Pathogenesis of the Graffi Murine Leukemia Retrovirus
... Graffi is extremely multipotent and induces complex leuke- mias. The induced leukemias were found to be heterogeneous. The leukemia from each animal harbored its particularities, and several leukemias showed ...
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Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene
... [45] as well as in chemotherapy resistance [24]. Recent studies showed that TPO/MPL/Bcl-xL or TPO/MPL/PI3K/ Akt signaling pathways are essential for maintaining AML driven by AML1-ETO [22, 23]. Here, we demonstrate that ...
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TWIST-1 promotes cell growth, drug resistance and progenitor clonogenic capacities in myeloid leukemia and is a novel poor prognostic factor in acute myeloid leukemia
... Efforts are being made in recent years to identify new prognostic markers in order to help in deciding the route of treatment for the patients. In the previous reports, expression of TWIST-1 is a statistically ...
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Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
... activated cell sorting (FACS) was performed for transduced BN cells at the London Regional Flow Cytometry Facility (Robarts Research Institute) (London, Ontario, Canada) using a FACSAria III flow cy- tometer using ...
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Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia
... persistence provided by cytotoxic T cells. CAR is an artificial antigen receptor that mediates antibody- targeted recognition. The binding between CAR and its antigen on tumor cells triggers a signal transduction cascade ...
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Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
... cancer/ leukemia samples, have been developed in the past ...certain cell surface anti- gens that are (or are not) expressed on CSC ...activated cell sorting (FACS) or magnetic cell sorting ...
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Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation
... Members of the early growth response (EGR) gene family are rapidly induced after mitogenic stimulation of diverse cell types. The present work has examined EGR gene expression during differentiation of ...
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Non-coding RNAs: a key to future personalized molecular therapy?
... lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) ...murine leukemia viral oncogene homolog 1 (ABL1) expression by demonstrating that ABL1 is a direct target of ...
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The Id-protein family in developmental and cancer-associated pathways
... Acute myeloid leukemia; Bcl: B-cell leukemia; bHLH: basic-HLH; CRMP1: Chromosome region maintenance protein 1; CSC: Cancer stem cell; CSN: COP9 signalosome; EMT: ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... Treg cell mechanism of forcing T cells into senescence ...Treg cell accumulations in hematological malignancies such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), ...
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Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion
... S2B). Cell proliferation was measured by manually cell counting, and was further confirmed by MTT ...estimated cell doubling time for miR-99a and Ctrl cells was ...accelerated cell division ...
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<p>A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia</p>
... A 63-year-old man was diagnosed as CML-CP due to elevated white blood cells (WBC) counts at the Air Force 454 Hospital (Nanjing, Jiangsu, China) and treated with imatinib in June 2011. Three months later, the patient ...
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<p>Tagraxofusp for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Brief Report on Emerging Data</p>
... of myeloid progenitors and play a key role in the regulation of hematopoiesis and in fl ammatory ...of myeloid progenitors, notably through the activation of the JAK/ STAT pathway after the reception of ...
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PubMedCentral-PMC4877686.pdf
... Chronic myeloid leukemia (CML) in pediatrics and young adults is uncommon accounting for only about 3% of all leukemias and <10% of all reported ...CML. 1 Since the introduction of tyrosine kinase ...
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Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
... Fig. 1 Gating strategy for identifying the CD4+ and CD8+ T cells and the percentage of memory T cell subsets in the patients with AML and healthy ...T cell populations from 27 HIs ...
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Sorafenib-Induced Apoptosis of Chronic Lymphocytic Leukemia Cells Is Associated with Downregulation of RAF and Myeloid Cell Leukemia Sequence 1 (Mcl-1)
... NaCl, 1% Triton X-100, ...with 1 mmol/L phenylmethylsulfonyl fluo- ride, Halt phosphatase inhibitor [Thermo Fisher Scientific, Rockford, IL, USA], 1 mmol/L sodium vanadate, 1 mmol/L sodium ...
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Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17)(q32;q11)
... Although PDGFRB fusions are rare, they can be ob- served in a diverse range of hematological malignancies including Ph-like acute lymphoblastic leukemia (ALL), AML, and atypical CML. These fusions have an adult ...
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Landscape of gene fusions in epithelial cancers: seq and ye shall find
... lymphoblastic leukemia; AML: Acute myeloid leukemia; APL: Acute promyelocytic leukemia, cholangio cholangiocarcinoma; CML: Chronic myeloid leukemia; CRC: Colorectal carcinoma; ...
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