N-glycosylation
The N-glycosylation processing potential of the mammalian Golgi apparatus
... We set out to evaluate how the level of glycan heterogeneity is affected by different variables in our model of N-glycosylation. An important variable is the number of cisternal elements, which is known to ...
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The multiple evolutionary origins of the eukaryotic N-glycosylation pathway
... and N-glycosylation are highly intertwined, as inhibition of one enhances the other and both PMT and N-OST belong to the glycosyltransferase family C (GT-C) and may be distantly related ...protein ...
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The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation
... sites on CD200R1. Potential N-glycosylation profiles of CD200R1 were presented. There are four sites at Asn35, Asn44, Asn192 and Asn314 (Asn-X-Ser/Thr) as pre- dicted by NetNGlyc 1.0 (Fig. 1d). Recent ...
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Posttranslational N glycosylation of the hepatitis B virus large envelope protein
... S-specific glycosylation site of L (N309) was mutated in ...preS-linked glycosylation of ...preS-specific glycosylation site in each ...two N- glycosylation sites within the preS domain ...
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In-depth mapping of the mouse brain N-glycoproteome reveals widespread N-glycosylation of diverse brain proteins
... canonical N-linked glycosylation motif is N-!P-[S|T|C] (where !P is not ...identified N-glycosylation sites, 8084 of which were valid for pLogo generation ...
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Two Distinct N Glycosylation Pathways Process the Haloferax volcanii S Layer Glycoprotein upon Changes in Environmental Salinity
... distinct N-linked gly- cans under low-salt conditions but not at elevated ...tetrasaccharide N-glycosylation machin- ery only at the lower salinity could be ...the N-linked pentasaccharide ...
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Regulation of susceptibility and cell surface receptor for the B-lymphotropic papovavirus by N glycosylation.
... Here we describe that inhibition of cellular glycoprotein N glycosylation by tunicamycin as well as blocking of the formation of complex and hybrid N oligosaccharide chains by deoxymanno[r] ...
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The changes of immunoglobulin G N glycosylation in blood lipids and dyslipidaemia
... IgG glycosylation, it has been shown that the presence of bisecting GlcNAcs reduce galactosylated IgGs [6, 45, ...IgG glycosylation mecha- nism could be part of the molecular mechanism leading to the ...
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Analysis and Function of Prototype Foamy Virus Envelope N Glycosylation
... its N and C termini located intracytoplasmically (10, ...The N-terminal signal or leader peptide (LP) has a type II conformation, whereas the C-terminal TM subunit has a type I ...the N-terminal ...
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N glycosylation requirements in neuromuscular synaptogenesis
... requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well ...hybrid N-glycosylation requires MGAT1 ...
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Serum Protein N-Glycosylation Changes with Rheumatoid Arthritis Disease Activity during and after Pregnancy
... with N-glycosylation changes of immunoglobulin ...high-throughput glycosylation analysis allow the assessment of the N-glycome of human sera as ...protein N-glycosylation ...
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Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation
... less N-glycosylated sites and therefore, were not trun- cated products of translation ...inhibited N-glycosylation of the newly synthesized protein but did not remove N-glycans from the mature ...
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Location-Specific, Unequal Contribution of the N Glycans in Simian Immunodeficiency Virus gp120 to Viral Infectivity and Removal of Multiple Glycans without Disturbing Infectivity
... extensive N glycosylation of the envelope ...each N glycan for viral infectivity, we individually silenced all 23 N glycosylation sites in the gp120 subunit of SIVmac239 envelope ...
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Braunger, Katharina Isabelle (2018): Cryo-EM analysis of mammalian co-translational membrane protein insertion and N-linked glycosylation. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Extended cryo-EM analysis of the OP96 biogenesis intermediate revealed an unassigned rod-like density intercalated between Sec61 and OST. We provision- ally identified the additional helical segment as the TMH of the ...
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Higel, Fabian Benjamin (2014): Pharmacokinetic profiling of therapeutic proteins and variants by mass spectrometry. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... in N-glycosylation of glycoproteins such as IgGs have been connected to various diseases and aging in several ...2-AA N-glycan elution from the RP column according to their glycan type ...IgG ...
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Fear vs Hope: Do Discrete Emotions Mediate Message Frame Effectiveness In Genetic Cancer Screening Appeals
... Naturally, N-glycoprotein can be synthesized by the oligosaccharyl transferases (OST) which can transfer glycans from a dolichol-phosphate glycolipid to Asn in a consensus Asn-Xaa- Ser/Thr (Xaa ≠ Pro) sequon of ...
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N-Linked Glycosylation Protects Gammaretroviruses against Deamination by APOBEC3 Proteins
... These results now raise the question as to whether gammaret- roviruses that are permissive to low levels of deamination, by way of less intensely glycosylated gPr80, have a greater success at in- fecting and persisting ...
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Molecular Determinants of Species Specificity in the Coronavirus Receptor Aminopeptidase N (CD13): Influence of N-Linked Glycosylation
... Aminopeptidase N (APN), a 150-kDa metalloprotease also called CD13, serves as a receptor for serologically related coronaviruses of humans (human coronavirus 229E [HCoV-229E]), pigs, and ...an ...
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Coordinate Deletion of N-Glycans from the Heptad Repeats of the Fusion F Protein of Newcastle Disease Virus Yields a Hyperfusogenic Virus with Increased Replication, Virulence, and Immunogenicity
... potential N-glycosylation acceptor sites in the F pro- ...of N-linked glycosylation of the NDV F protein in viral biological activities and viral pathogenesis using a previously described ...
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Functional Role of N-Linked Glycosylation in Pseudorabies Virus Glycoprotein gH
... of N-linked glycans in the alphaherpesvirus pseudorabies virus (PrV) glycoprotein H (gH), which is an essential component of the conserved core herpes- virus fusion ...potential N-linked ...
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