N-Methyl-D-Aspartate
Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography
... The two most common targets of encephalitis associ- ated pathogenic autoantibodies are the recently identified leucine rich glioma inactivated 1 protein (LGI1), which is extracellularly complexed with voltage-gated ...
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Anti N Methyl D Aspartate Receptor Encephalitis with Concomitant Detection of Epstein Barr Virus
... Introduction: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an important cause of encephalitis worldwide. While some cases are associated with neoplasms, in the remaining cases ...
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Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons
... While N-methyl-D-aspartate receptor (NMDAR) signaling is physiologically essential for neuronal survival (2), it might have excitotoxic proapoptotic effect under pathophysiological conditions ...
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Original Article Effects of N-methyl-D-aspartate receptor on remifentanil-induced hyperalgesia
... hyperalgesia. N-methyl and D-aspartate-related receptor (NMDAR) is widely found in animal and plays an important role in central nerve system and ...of ...
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N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis
... The amino acid glutamate is the major excitatory neurotransmitter in the mammalian central nervous sys- tem (CNS). It can act on ionotropic (iGluR) and metabo- tropic (mGluR) receptors. iGluRs are ligand-gated non- ...
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Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors
... and mitochondrial function [20,21] (also see review [22]). Moreover, a large body of recent evidence has also drawn the link between mercury and glutamate- mediated excitotoxicity. For instance, mercury has been shown to ...
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Anti N methyl D aspartate receptor encephalitis with an imaging invisible ovarian teratoma: a case report
... Case presentation: A 25-year-old white woman with anti-N-methyl-D-aspartate receptor encephalitis presented with behavioral changes and seizures that were confirmed to be secondary to ...
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Atypical presentation of anti N methyl D aspartate receptor encephalitis: two case reports
... ANA: Antinuclear antigen antibodies; beta-HCG: Beta-human chorionic gonadotropin; CSF: Cerebrospinal fluid; CT: Computed tomography; EEG: Electroencephalography; EKG: Electrocardiogram; HLA: Human leukocyte antigen; ...
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The diffuse involvement of anti-N-methyl-D-aspartate receptor encephalitis in brain: a case report
... Anti-N-methyl-D-aspartate receptor (NMDAR) encephal- itis is a severe autoimmune disorder first described in 2007 [1]. It is associated with antibodies in the serum and cere- brospinal fluid ...
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Anti-N-methyl-D-aspartate receptor encephalitis in China
... N-methyl-D-aspartate receptors (NMDARs) are mainly distributed in the central nervous system, and play important roles in the mechanisms of learning and memory. A newly discovered disease ...
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Changes in Striatal N-methyl-D-aspartate (NMDA) Stimulation of Dopamine Release and Receptor Subunit Expression During Expression of and Recovery from MPTP-Induced Parkinsonism
... mescencephalic nuclei 25 project to the striatum. Loss of striatal dopamine innervation in uni-lateral 6-OHDA lesioned rats alters glutamate receptor binding 26, 16, 28 and glutamate receptor subunit expression 4, 3 . ...
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Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs
... N-methyl-D-aspartate receptors (NMDARs) are a sub- type of ionotropic glutamate receptors and are widely expressed throughout the nervous system [1]. They are required for induction and ...
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Anti-N-methyl-D-aspartate receptor encephalitis with serum anti-thyroid antibodies and IgM antibodies against Epstein-Barr virus viral capsid antigen: a case report and one year follow-up
... (asterisk). N-methyl-D-aspartate receptor subunit 1 (NR1) immunostain demonstrated primitive neural tubes (B) within teratoma, while neurofilament immunostain showed mature ganglion cells ...
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N methyl D aspartate (NMDA) mediates vascular relaxation via nitric oxide (NO) in rats but not in mice
... Figure 3. (a) contracting effect of NA 1 µM (arrow a) upon an untreated (CONTROL) CD1 mouse aortic ring. Then nitrites 100 µM (arrow b) and NO 6.6 µM (arrow c), respectively were added to the aortic ring. Note that ...
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Novel hypoglycemic injury mechanism: N methyl D aspartate receptor mediated white matter damage
... Recovery of WM function after aglycemia depended on the duration of aglycemia and tissue glycogen, but not on age. (A) Shown is the effect of a standard 60 min period of aglycemia on normalized CAP area for a single ...
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<p>Anti-N-methyl-D-aspartate receptor encephalitis mimics neuroleptic malignant syndrome: case report and literature review</p>
... It is worth noting that NMS may be caused by recent antipsychotic exposure or it may possibly be a natural progression of anti-NMDA receptor encephalitis itself in a subset of patients. Approximately, three-quarters of ...
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The importance of N methyl d aspartate (NMDA) receptors in subtraction of electrosensory reafference in the dorsal nucleus of skates
... At the peripheral zone of the dorsal nucleus, the somas and the apical and basal dendrites of the retrogradely labeled AENs were stained with rabbit anti-NR1 antibody (Fig.3A–D, Fig.4). The NR1 antibody staining ...
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Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis
... To be included, patients had to meet the recognized cri- teria for NMDAR-E associated with the presence of IgG directed against NMDAR in the CSF [7, 29]. Cases of NMDAR-E referred to the French Reference Center for ...
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Single nanoparticle tracking of N methyl d aspartate receptors in cultured and intact brain tissue
... with fluorescence recovery after photobleaching approaches, 26 which contrasts with the observations made here on GluN1- NMDAR which were found to be less diffusive in acute brain slices. While the nature of NMDAR ...
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N Methyl d Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
... NMDARs form tetrameric complexes that consist of several homologous subunits. The subunit composition of NMDARs is plastic, resulting in a large number of receptor subtypes. As each receptor subtype has distinct ...
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