Nasal administration
Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences
... Oral administration of an Ag can induce tolerance by different mechanisms, depending upon the dose of Ag that was fed ...in nasal toler- ance (7, 10). Studies on the protecting effect of nasal ...
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Immunogenicity Evaluation of Recombinant Staphylococcus aureus Enterotoxin B (rSEB) and rSEB-loaded Chitosan Nanoparticles Following Nasal Administration
... Staphylococcal enterotoxin B (SEB), apotent superantigen, is responsible for many disorders caused by Staphylococcus aureus. With regard to the appearance of multidrug-resistant strains of the bacteria, there is a great ...
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Development and Characterization of Mucoadhesive Nanoparticles of Topiramate for Nasal Administration
... the nasal cavity is considerably increased for nanoparticles compared to ...the nasal administration by ionic gelation ...for nasal delivery of TPM found to have high encapsulation efficiency ...
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Prehospital analgesia using nasal administration of S-ketamine – a case series
... intranasal administration of drugs is used in some ...cases. Nasal as opposed to intravenous analgesia may reduce the time spent on the scene of the accident and most likely reduces the need to expose the ...
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FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF IN SITU LISINOPRIL GEL FOR NASAL ADMINISTRATION
... from nasal mucosal ...sheep nasal mucosa was used. A nasal mucosa with thickness of ...sheep nasal cavity and instantly secured with the mucosal side out onto each glass vial using a ...
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Preparation and In Vitro Characterization of Mucoadhesive Hydroxypropyl Guar Microspheres Containing Amlodipine Besylate for Nasal Administration
... The nasal cavity as a site for systemic absorption of drugs has advantages such as relatively large surface area, porous endothelial membrane, highly vascularized epithelial layer, enhanced blood flow, avoidance ...
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Applications of Nanomedicine, Nanoparticle Drug System for Oral,Ocular and Nasal Administration
... for nasal and ophthalmic delivery of drugs group of nano particles has also shown prominence for use neuro-disorders, in which large number of other drugs ...
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PREPARATION AND CHARECTERIZATION OF PRONIOSOMAL DRY POWDER INHALER OF BUDESONIDE USING LACTOSE CARRIER FOR NASAL ADMINISTRATION
... Proniosomes consist of dry, free flowing powder which on hydration forms niosomes for DPI, suitable for administration by nasal route for pulmonary delivery. In the present investigation proniosomes were ...
19
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats
... intranasal administration, drugs not only circumvent the BBB, but they also avoid the hepatic first-pass effect and/or degradation in the blood compartment, a particularly important issue in the case of peptide ...
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Optimization of in situ gelling system for nasal administration of celecoxib
... ocular, nasal, vaginal, etc. Administration of Celexocib as in-situ gelling system for nasal route could enhance the bioavailability and therapeutic activity of the ...thermoresponsive nasal ...
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Studies on Temperature Induced Mucoadhesive in Situ Gel Formulation of Rizatriptan Benzoate for Nasal Administration.
... Zolmitriptan nasal gel was aimed to improve absorption and patient ...Zolmitriptan nasal gel, bioadhesive polymers such as sodium alginate, sodium carboxyl methyl cellulose and polyvinyl pyrollidine (PVP ...
196
Pharmaceutical application of nanoparticles in drug delivery system
... for nasal vaccine delivery: - At present, there is considerable excitement within the nanotechnology field with regard to the potential use of nanosystems as carriers for mucosal vaccine delivery ...the ...
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Dose Response of Attenuated Bordetella pertussis BPZE1-Induced Protection in Mice
... tract, and several administrations of very high doses were re- quired to protect mice against subsequent challenge with vir- ulent B. pertussis. More recently, we have developed the atten- uated BPZE1 vaccine strain, ...
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INTRANASAL THERMOREVERSIBLE MUCOADHESIVE GELS: A Review
... including nasal drug delivery, where the increase in the viscosity at the body temperature, increase the residence time of drug in the nose [6] ...successful nasal formulation, with increased contact time ...
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Effect of Intranasal Administration ofLactobacillus casei Shirota on Influenza Virus Infection of Upper Respiratory Tract in Mice
... increased. Administration of PBS into the respiratory tract apparently enhanced viral spread to the lower respiratory tract and increased pulmonary dam- age, and as a result, it increased the mortality ...
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Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery
... for nasal administration could not be prepared because Pep3 was not completely soluble in 5% dextrose solution at the con- centration for nasal administration ...intranasal ...
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NON-INVASIVE DELIVERY SYSTEM FOR MUCOSAL IMMUNIZATION AND SYSTEMIC ACTION OF THERAPEUTIC PROTEINS
... whereas control formulations have shown considerably activity in the initial hrs. Pharmacokinetic determination of insulin mirrored the results of pharmacodynamic studies. A maximum of 186.3 μIU/ml insulin was found at 8 ...
17
Nano formulation: A novel approach for nose to brain drug delivery
... the nasal cavity by penetrating the cribriform plate, which brings the neurons into the nasal ...the nasal cavity to the brain, thus circumventing the BBB ...optimized nasal formulation showed ...
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A clinicopathological study of rhinosporidiosis in a tertiary care hospital
... The disease has been isolated not only from humans but also from other animals such as cattle, buffaloes, horses, mules. Mode of spread also remains debatable, the more acceptable being that it spreads from sand and ...
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ajrccm.157.6.9709043.pdf
... human nasal epithelium in vitro (20, ...the nasal epithelium of patients with CF in vivo ...the nasal or bronchial epithelium is known to lead to a 10- to 100-fold dilution of drug concentration (19) ...
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