naturally occurring mutations
Naturally occurring mutations in the human 5 lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription
... be naturally occurring mutations that could either modify 5-LO gene transcription or modify the putative protein derived from translation of 5-LO ...for mutations using genomic DNA derived ...
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Naturally Occurring Mutations Define a Novel Function of the Hepatitis B Virus Core Promoter in Core Protein Expression
... Core promoter mutations have been associated with more aggressive disease, including fulminant hepatitis (2, 9, 31, 34, 36). The MT5/6-induced increase in core protein expression and increased replication could ...
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Naturally Occurring Mutations in the PA Gene Are Key Contributors to Increased Virulence of Pandemic H1N1/09 Influenza Virus in Mice
... Since there was only one amino acid substitution for each re- assortant carrying the SD731 PB2 (T588I), NA (V106I), or NS (I123V) protein in the CA04 backbone, we propose that these mutations are likely to be ...
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Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability
... The results of our current study further showed that this natural switch from serine to glycine at PB1–216 in- creased the mutation frequency of pdmH1N1 by redu- cing the fidelity of RdRp (Fig. 3; Table 1). The A/H1N1 ...
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Naturally Occurring Mutations within 39 Amino Acids in the Envelope Glycoprotein of Maedi-Visna Virus Alter the Neutralization Phenotype
... VR2), mutations in the region between StyI at nt 7613 and XbaI at nt 7768 were necessary and sufficient to abolish neutralization (recombi- nants VB1 and ...
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Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice
... We examined the molecular basis of virulence of pandemic H1N1/09 influenza viruses by reverse genetics based on two H1N1/09 virus isolates (A/California/04/2009 [CA04] and A/swine/Shandong/731/2009 [SD731]) with ...
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Biased Signaling in Naturally Occurring Mutations in Human Melanocortin-3 Receptor Gene
... A naturally occurring mutation in MC4R identi- fied from obese patients with binge eating disorder substitutes the cognate Phe with Leu at codon 51, leading to unchanged ligand binding and cAMP sig- naling ...
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Naturally occurring mutations to HCV protease inhibitors in treatment naïve patients
... 15. Thompson AJ, McHutchison JG: Antiviral resistance and specifically targeted therapy for HCV (STAT-C). J Viral Hepat 2009, 16:377 – 387. 16. Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, ...
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Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment naïve patients with chronic hepatitis C
... Recently, novel (treatment-emergent) NS5B mutations (L159F, L320F and V321A) were detected in HCV in- fected patients who failed sofosbuvir treatment [29]. Im- portantly, a baseline polymorphism at position 316 ...
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Structural And Functional Studies Of The Human Telomeric Pot1-Tpp1 Complex And Its Role In Human Disease
... that naturally occurring mutations in the N-terminal OB-folds of POT1 disrupt POT1-DNA binding and results in telomere elongation and dysfunctional telomere ...C-terminal mutations on POT1 ...
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Autoantibody mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade
... or naturally-occurring mutations in one or more of the genes encoding complement components C3, C5, and FcRg, the cytoplasmic signaling chain shared by the activating ...
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Identification of an essential region for internal initiation of translation in the aphthovirus internal ribosome entry site and implications for viral evolution.
... point mutations in the IRES element, a U-to-C transition at position 2 376 and an A-to-G transition at position 2 15 (counting as 1 1 the adenosine of the first func- tional AUG [see ...of naturally ...
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Stability and Activity of Naturally Occurring RGS2 Variants
... are naturally occurring mutations in this region at residues 5 (RGS2 M5V), 14 (RGS2 R14I), 18 (RGS2 K18N) and 23 (RGS2 G23D), which may be associated with a phenotypic profile seen in individuals ...
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Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment naïve patients
... resistance mutations and other mutations conferring low level resistance to NS5A HCV inhibitors (Daclatasvir, Ledipasvir, GSK805 and Samatasvir), as well as nucleo- sides (Sofosbuvir, Mericitabine, and ...
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Toxoplasma antigens recognized by naturally occurring human antibodies
... To further define the antigens recognized by these naturally occurring antibodies, we studied PB of sera of 44 adults and 9 children who had no serological evidence of the infection.. go[r] ...
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Cognitive dysfunction in naturally occurring canine idiopathic epilepsy
... occurs naturally in domestic dogs but its impact on canine cognition has yet to be studied, despite canine cognitive dysfunction (CCD) recognised as a spontaneous model of de- ...
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Approaches towards the synthesis of naturally occurring toxic alkaloids
... The resulting biphasic system was then extracted with ethyl acetate 3 x 20 ml and the organic layers were then combined, dried with MgSC>4 and the solvent removed in vacuo to yield a pal[r] ...
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Relative Resistance of HLA B to Downregulation by Naturally Occurring HIV 1 Nef Sequences
... IMPORTANCE Recognition of genetically diverse pathogens by the adaptive immune system represents a primary strategy for host defense; however, pathogens such as HIV-1 can evade these responses to achieve persistent ...
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Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen.
... 4 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology Naturally Occurring Escape Mutants of Hepatitis B Virus with Various Mutations in the S Gene in Carriers Serop[r] ...
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Identification and characterization of naturally occurring splice variants of SAMHD1
... Additional file 1: Figure S1. Antiviral activity of naturally occurring splice variants of SAMHD1. Human monocytic U937 cells were transduced using a lentiviral vector system (pCDH; Systems Biosciences, ...
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