nerve crush
Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models
... Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease resulting from motor neuron degeneration that causes muscle weakness, paralysis, and eventually respiratory failure. We investigated whether ...
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Optic nerve crush activates the genomic fabrics of the Complement cascade and Delta-Notch signaling
... optic nerve crush (ONC) and applied systems biology approaches to better understand the molecular mechanisms related with the retinal remodeling after induction of RGC ...
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Brimonidine protects against loss of Thy-1 promoter activation following optic nerve crush
... retinal nerve fiber layer axon bundles converging at the optic nerve ...optic nerve crush, a major portion of these fluorescent retinal neurons cease expression of CFP over the first one to ...
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Original Article Mesenchymal stem cell-derived extracellular vesicles promote nerve regeneration after sciatic nerve crush injury in rats
... peripheral nerve regeneration remain poorly ...sciatic nerve crush injury ...the crush-injured segment of rat was treated by BMSC-EVs or PBS, and assessed the nerve ...in nerve ...
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Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush
... of nerve growth factor and myelin basic protein in ...sciatic nerve crush injury model was used to evaluate the effectiveness of PDAPEI/miR-221/222 complexes for nerve regeneration in ...
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Brief electrical stimulation and synkinesis after facial nerve crush injury: a randomized prospective animal study
... facial nerve crush injury, animals in groups 2 and 4 received brief electrical ...sciatic nerve rat model ...Following nerve re- pair, the first wire was looped around the proximal stump of ...
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Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush
... atic nerve crush, while treatment with PEA-OXA signifi- cantly reduced the expression of c-fos, consistently with the decrease of the mechanical allodynia and thermal hyperalgesia that we ...sciatic ...
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Bogijetong decoction and its active herbal components protect the peripheral nerve from damage caused by taxol or nerve crush
... BGJTD is a decoction composed of as many as 18 dif- ferent herbal drugs. As an initial step to sort out the active components in its efficacy on the nerve repair, we divided them into 4 different groups (i.e., Ba, ...
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Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice
... as nerve growth factor (NGF), brain- derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) as well as neuronal activity can potentiate the ex- pression of Nrn1 ...
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Analysis of Myelin and Neurofilament Content in a Sciatic Nerve Crush Injury Model
... peripheral nerve injury are critical in our efforts to better understand the outcomes after such injuries and to advance our current clinical models of peripheral nerve ...calibrated crush injuries ...
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EFFECT OF VATA GAJANKUSHA RASA IN RAT SCIATIC NERVE CRUSH INJURY .......
... High fiber density and thicker myelin of nerves indicates better regeneration and functional recovery of the group III animals when compared to group II animals showing the drug ha[r] ...
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CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype
... sciatic nerve crush injury, a single injection of CD300f-IgG2a significantly increased the number of to- mato lectin-positive macrophages and CD206-positive cells and decreased iNOS immunoreactivity at 10 ...
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The influence of inactivity on membrane resting conductances of rat skeletal muscle fibres undergoing reinnervation
... Our experiments show the following: 1 after nerve crush the resting membrane conductances of the corresponding muscle fibres are almost restored to their control values within 30 days; 2[r] ...
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Neuroprotective Effect of Ultra-High Dose of Methylcobalamin in Models of Mononeuropathy in Rats
... peripheral nerve injuries occasionally experience chronic ...sciatic) nerve as a common ...sciatic nerve ligation model (PSNL), and the spinal nerve ligation model ...[4] Nerve ...
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Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
... p38β [11]. However, the physiological function of p38 MAPK in vivo remains controversial. Temporin et al. reported that SB 203580 reduced axonal length in a neurite outgrowth assay. In that study, the activation of RhoA ...
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Comparative analysis of hyperexcitability and synaptic facilitation induced by nerve injury in two populations of mechanosensory neurones of Aplysia californica
... ipsilateral nerve crush ...during nerve crush (see Walters et ...after nerve crush occurred only in sensory populations that had sustained axonal injury; it was not observed in ...
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Degenerative and regenerative changes after loss of neuromuscular interaction during early postnatal life
... neonatal nerve injury or ...sciatic nerve crush at birth there is an extensive loss of motoneurones (Romanes, 1946; Zelena and Hnik, 1963; Schmalbruch, 1984; Lowrie et al, ...peripheral nerve ...
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Systemic functional enrichment and ceRNA network identification following peripheral nerve injury
... Peripheral nerve injury is a worldwide clinical issue that impacts patients ’ quality of life and causes huge society and economic ...peripheral nerve injury, the regenerative abilities are very limited and ...
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Electro acupuncture on functional peripheral nerve regeneration in mice: a behavioural study
... Walking track analysis To assess sensorimotor func- tional recovery, we used the CatWalk method for both static and dynamic gait analysis [14]. Briefly, animals crossing a walkway with a glass floor are videotaped using ...
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Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury
... sciatic nerve crush injury. The sciatic nerve functional index (SFI) and latency of thermal pain (LTP) of the hind leg sciatic nerve were measured before the operation and at 7, 14, 21, and 28 ...
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