neuronal nitric oxide synthase
Distribution of neuronal nitric oxide synthase (nNOS)-immunoreactive elements in the rabbit piriform cortex
... contain neuronal nitric oxide synthase (nNOS) may play a key role during spatial learning and in the modulation of initiation, propagation and generalisation of seizures in various ...
10
Urinary Magnesium and Calcium Excretion after Neuronal Nitric Oxide Synthase Inhibition in Normotensive and Spontaneously Hypertensive Rats.
... Experiments were carried out on conscious, male, normotensive Wistar rats (n=10) and spontaneously hypertensive rats (SHR, n=10) at the same age of 12-14 weeks. The study was performed in accordance with institutional ...
7
The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish
... for neuronal nitric oxide synthase (nNOS) in early vertebrate development we investigated nNOS mRNA expression and cGMP production during development of the zebrafish Danio ...
13
The selective neuronal nitric oxide synthase inhibitor 7-nitroindazole has acute analgesic but not cumulative effects in a rat model of peripheral neuropathy
... of neuronal nitric oxide synthase (nNOS), the enzyme responsible for the generation of the neurotransmitter nitric oxide in the nervous system, in a model of peripheral ...
6
Original Article Overexpression of ADAMTS-13 and neuronal nitric oxide synthase relates with neuropathology in streptozotocin-induced type 1 diabetic rats
... (NF), neuronal nitric oxide synthase (nNOS) and glial fibrillary acidic protein (GFAP) in brain tissues of experimental streptozotocin (STZ)-induced diabetic ...that nitric oxide ...
18
Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy
... Gastrointestinal dysfunction is common in diabetic patients. In genetic (nonobese diabetic) and toxin-elicited (streptozotocin) models of diabetes in mice, we demonstrate defects in gastric empty- ing and nonadrenergic, ...
13
Inhibition of Neuronal Nitric Oxide Synthase Increases Aggressive Behavior in Mice
... Materials and Methods: Aggressive behavior, as well as brain citrulline levels, were monitored in adult male mice after treatment with a specific nNOS inhibitor, 7- nitroindazole (7-NI) [r] ...
7
Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats
... pathway, nitric oxide (NO) has been suggested to serve as another intracellular signaling molecule that mediates the ADM actions ...from neuronal NO synthase (nNOS) ...
9
Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy.
... Here, we review the various approaches to restore NO bioavail- ability in dystrophic muscle including nNOS overexpres- sion, ˪ -arginine administration, phosphodiesterase (PDE) inhibitio[r] ...
11
Original Article Phosphorylated neuronal nitric oxide synthase in neuropathic pain in rats
... Abstract: Neuropathic pain caused by nervous system damage or system dysfunction. The pathogenesis and the mechanism underlying neuropathic pain remains unclear. The only known neurobiological component involved in the ...
9
Nitric Oxide-Dependent Penile Erection in Mice Lacking Neuronal Nitric Oxide Synthase
... In cross sections of the proximal penis of the wild-type (A) and nNOS- mouse (B), staining of dorsal penile nerves (arrow) is observed only in the wild-type penis. Counterstaining with h[r] ...
9
Neuronal nitric oxide synthase in hypertension – an update
... e.g. nitric oxide [18], atrial natriuretic peptide [19, 20] and phosphodiesterase 5 inhib- ition [21]; antagonizing beta1-adrenergic pathway [22], ...
7
Neuronal Nitric Oxide Synthase Contributes to the Regulation of Hematopoiesis
... Nitric oxide (NO) signaling is important for the regulation of ...NO synthase (NOS) isoforms is ...the neuronal NOS isoform (nNOS) regulates hematopoiesis in vitro and in ...
9
PubMedCentral-PMC5107352.pdf
... expressing neuronal nitric oxide synthase (nNOS) without neuropeptide Y immunoreactivity in the stratum pyramidale and the stratum radiatum, parvalbumin in the stratum pyramidale, and ...
31
Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease
... Objectives: The study has measured expression of endothelial eNOS, inducible iNOS, and neuronal nitric oxide synthase nNOS in the lungs from biopsies of infants with pulmonary hypertensi[r] ...
9
Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats
... Objectives: This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (ID[r] ...
12
Impaired Ovulation in Mice with Targeted Deletion of the Neuronal Isoform of Nitric Oxide Synthase
... Two-tailed t-tests were used to assess the number of ovarian rupture sites, the number of oocytes recovered from the oviducts, and ovulatory effi- ciency of WT and nNOS-/- female mice.. [r] ...
7
Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission
... (1–5). Nitric oxide synthase (NOS), an enzyme that synthesizes NO from the amino acid L-arginine, is localized to neurons and nerve end- ings at the neuromuscular junction (6, 7); authentic NO or NO ...
7
Regulation of enteric neuron migration by the gaseous messenger molecules CO and NO
... of neuronal migration. Neuronal precursors emerge from proliferative zones in the foregut epithelium and perform extensive cell migrations before they assemble into discrete peripheral ganglia and gastric ...
9
The herbal formula KH 204 is protective against erectile dysfunction by minimizing oxidative stress and improving lipid profiles in a rat model of erectile dysfunction induced by hypercholesterolaemia
... and neuronal (nNOS) nitric oxide synthase, oxidative stress (8-hydroxy-2-deoxyguanosine), and ratio of smooth muscle cells and collagen fibres were evaluated in the serum and corpora ...
11