Neutralizing epitope
Identification of the V1 region as a linear neutralizing epitope of the simian immunodeficiency virus SIVmac envelope glycoprotein.
... linear neutralizing epitope. V1 region-specific neutralizing anti- bodies (NAb) were first demonstrated in a rabbit infected with a recombinant vaccinia virus carrying the env gene of human ...
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Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon
... of neutralizing MAbs is also useful in identifying neutralizing epitopes, a highly important step in the molecular design of ...the neutralizing epitope is modified in a viral gene delivery ...
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Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope.
... of neutralizing antibody ...a neutralizing epitope for an antibody that can neutralize by inhibiting cell surface ...the epitope and indirectly changes the conformation of the ...of ...
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Identification of a Continuous Neutralizing Epitope within UL128 of Human Cytomegalovirus
... 13B5 epitope structure, rendering the identified 13B5 epitope sequence insufficient for the effective stimulation of NAb ...13B5 epitope sequence is simply not optimal for EC-specific NAb induction ...
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Conserved Neutralizing Epitope at Globular Head of Hemagglutinin in H3N2 Influenza Viruses
... the epitope for F005-126, as well as helix A, the B loop, and helix ...an epitope including the VE domain in H5 HA prevents the conformational changes in HA, although the mechanisms for prevention remain ...
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Characterization of a Major Neutralizing Epitope on Human Papillomavirus Type 16 L1
... ping neutralizing epitopes on ...additional neutralizing sites, distinct from those defined by V5 and ...HPV-16 neutralizing antibody ...V5 epitope but lack the E70 binding site, or GU-2 VLPs, ...
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A Protective and Broadly Cross-Neutralizing Epitope of Human Papillomavirus L2
... other neutralizing epitopes, we performed similar depletion experi- ments with serum from a rabbit vaccinated with HPV16 L2 peptide ...HPV16 neutralizing titer of antiserum to HPV16 L2 peptide 11-200 drops ...
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Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope
... 1. Liao H-X, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L, Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia S-M, Montefiori DC, Parks R, Lloyd KE, ...
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A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1.
... These data suggest that the epitope of the MAb comprises the amino acid sequence ELDKWA corresponding to amino acids 662 to 667 of gpl60 of the HIV-1 BH1O isolate, with DKWA being the co[r] ...
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Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope.
... 6 0022-538X/881062107-08$02.00/0 Copyright © 1988, American Society for Microbiology Characterization of a Human Immunodeficiency Virus Neutralizing Monoclonal Antibody and Mapping of th[r] ...
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Amino acid sequence of a conserved neutralizing epitope of murine coronaviruses.
... We used fusion proteins, generated by expression of fragments of the MHV A59 E2 gene in pEX plasmids, and synthetic peptides in a PEPSCAN... Schematic representation of the MHV A59 E2 ex[r] ...
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Mapping an Adeno-associated Virus 9-Specific Neutralizing Epitope To Develop Next-Generation Gene Delivery Vectors
... As AAV is naturally occurring, most humans are exposed to it prior to adulthood and, therefore, have preexisting immunity (13). An estimated 80% of individuals are sero- positive for antibodies against at least one AAV ...
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A second neutralizing epitope of B19 parvovirus implicates the spike region in the immune response.
... To determine the epitopes recognized by neutralizing antibodies, the recombinant VP1 and VP2 capsid proteins and the 11 fusion proteins containing B19 parvovirus structural protein polyp[r] ...
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Anti-idiotypic mimicry of a neutralizing epitope on the glycoprotein B complex of human cytomegalovirus.
... 6815 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Experiments were carried out to investigate the ability of rabbit anti-idiotype antibodies Ab2, directed against an [r] ...
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Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8
... dicted epitope residues were verified through mutagenesis fol- lowed by in vitro and in vivo transduction ...ADK8 epitope can evade neutralization by the ADK8 MAb but retains the liver transduction ...
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Analysis and simulation of a neutralizing epitope of transmissible gastroenteritis virus.
... Three observations indicate that the linear sequence consisting of residues 1172 to 1187 might not be part of the actual binding site of the neutralizing MAbs: i the recognition of pepti[r] ...
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Identification of a neutralizing epitope on glycoprotein gp58 of human cytomegalovirus.
... The partial inhibition of the neutralizing activity of monoclonal antibody 7-17 by the nonneutralizing antibody 27-287 was not unexpected, because both antibodies inhibited one another i[r] ...
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Characterization of a Discontinuous Neutralizing Epitope on Glycoprotein B of Human Cytomegalovirus
... YK epitope), which are immediate neighbors on the AD-4 surface, were found to be essential for binding of the human ...YK epitope is dominant for the AD-4-specific neutralizing antibody re- sponse ...
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Producing a Subunit Vaccine for Porcine Epidemic Diarrhea Virus
... In contrast to S, M is more conserved (Chen et al., 2014; Sato et al., 2011). PEDv was propagated through serial passages in Vero cells, and gene sequences were analyzed at the 34 th , 61 st , and 100 th passage. Vero ...
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Peptides Designed To Spatially Depict the Epstein-Barr Virus Major Virion Glycoprotein gp350 Neutralization Epitope Elicit Antibodies That Block Virus-Neutralizing Antibody 72A1 Interaction with the Native gp350 Molecule
... Previous epitope map- ping of gp350 revealed only one dominant neutralizing epitope, which has been shown to be the target of the monoclonal anti- body ...EBV-neutralizing epitope would ...
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