NF-E2-related factor 2 (Nrf2)
Original Article Hyperbaric oxygen treatment promotes antioxidative effects on rats with acute carbon monoxide poisoning via NF-E2-related factor 2 activation
... of NF-E2-related factor 2 (Nrf2) and its cytoplasm binding protein kelch-like ECH-associated protein 1 (Keap1) was evaluated by immunohistochemical staining and Western ...
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Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal
... Background: NF-E2-related factor 2 (NRF2) regulates a battery of antioxidative and phase II drug metabolizing/ detoxifying genes through binding to the antioxidant response elements ...
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Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
... Statin has been known not only as their cholesterol-lowering action but also on their pleiotropic effects including anti-inflammatory and anti-oxidant as well as anti- cancer effect. Nrf2 ...
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Anti stress gene response in cell and tissue ageing : role of transcription factor NF E2 related factor 2 and effect of dietary activators
... Evidence from cell senescence studies have been used to explain the basis of healthy ageing as well as develop food supplements promoting the delay of ageing. Since these discoveries, there has been marked expansion of ...
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Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacological activation of Nrf2 (NF E2 related factor 2)
... Consistent with the notion that NASH is accompanied by oxidative stress, increases in malondialdehyde and oxidized protein were observed in livers of HF55Fr/HF30Fr-fed mice, and these increases were attenuated by TBE-31 ...
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Original Article Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival
... of NF-E2-related factor 2 (Nrf2), NAD(P)H quinine oxidoreductase 1 (NQO1), multidrug resistant protein 1 (MRP1), cmyc and p53 in CRC and their relationships to Duke’s stage and clinical ...
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Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2
... transcription factor NF-E2-related factor 2 (Nrf2) is a master regulator of antioxidant defences that controls a battery of antioxidant and detoxification genes containing ...
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The stress signalling pathway nuclear factor E2-related factor 2 is activated in the liver of sows during lactation
... and NF- κ B during lactation is mediated by various stimuli including reactive oxygen species (ROS), bacterial lipopolysaccharide (LPS) and cytokines, which are known activators of both, Nrf2 and NF- κ ...
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Donor variability may mask dimethyl fumarate’s effects on nuclear factor E2 related factor 2 in human peripheral blood mononuclear cells
... affect NF-κB activation and pro- duction of a variety of inflammatory mediators; we have previously demonstrated that DMF stimulates produc- tion of the immunomodulator cAMP via the prostaglan- din E2 ...
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Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery
... on NF-E2–related fac- tor 2 (Nrf2), a redox-regulated transcription factor that controls the expression of a battery of detox- ification and antioxidant proteins via its binding to ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor-kappa B (NF- B p65) and nuclear fac- tor-E2-related factor 2 (Nrf2) have been drawn an increasing attention for their role in protecting tissue injury such as ...
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The cap 'n' collar family member NF E2 related factor 3 (Nrf3) is expressed in mesodermal derivatives of the avian embryo
... Fig. 1. Expression of Nrf3 in the embryonic chicken. (A) In situ hybridization with an antisense probe against Nrf3 mRNA in a HH18 embryo. Expression is seen in a medial stripe within each somite and in cells migrating ...
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Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice
... decoy-mediated NF-κB inhibition was sufficient to induce cell non-vitality of BALF cells in 52 day smoke-induced mice, we examined using trypan blue staining at 24 hour after treatment with NF-κB decoy ODNs ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... Abstract: Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by the demyelination of neuronal axons. Four different patterns of demyelination have been described, showing the ...
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Transient Hemophagocytosis With Deficient Cellular Cytotoxicity, Monoclonal Immunoglobulin M Gammopathy, Increased T-Cell Numbers, and Hypomorphic NEMO Mutation
... Since early infancy, he has had a pruritic eczematous skin rash that has been indistinguishable from atopic dermatitis except that the distribution of the rash has not changed with age. The neck and intertriginous areas ...
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Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis.
... Figure 2 LV-NRF2–mediated protection in neuronal and astrocytic cells. (a) NRF2 protein levels of NSC34 cells transduced with LV-NRF2 at 3 dpt relative to endogenous levels of untransduced cells (N = 3, mean ± ...
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Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats
... Figure 1 TF treatment protected the rats from intracerebral hemorrhage (ich)-induced brain injury. corner test (A) and paw placement test (B) were performed 24 hours after ich to evaluate the rats’ behavioral ...
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Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state
... In this study, 24 h after ISO administration, ST-segment elevation was recorded by lead II ECG. The ECG patterns in each group are shown in Figure 1. As seen in Figure 1, there was remarkable elevation in ST-segment in ...
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Estrogen Receptor Alpha 36 Gene Knockdown Promote the Expression of NF κB in PC12 Cells
... of NF-κB in normal cultured PC12 cells and to provide an experimental foundation for understanding the function of ER-α36 in nerve ...of NF-κB after transfection. The results showed that NF-κB ...
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The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID.
... The function of the distal E2 binding site in repression could be i to stabilize the proximally bound E2 factor cooperatively; ii to interfere with the mechanism of interaction of cellul[r] ...
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