NF-κB
NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
... 3: NF-κB/RelA is involved in FF-induced inhibition of ...of NF-κB/RelA but also induced dissociation of NF-κB/RelA and HIF1α in the ...inhibited NF-κB/RelA ...
10
Control of oncogenesis and cancer therapy resistance by the transcription factor NF κB
... of NF-κB in onco- genesis comes from experiments in which the NF- κ B pathway has been directly ...of NF- κ B by expression of a modified form of I κ B α (super- repressor IκBα) (15) or by a ...
7
Original Article Effects of NF-κB and hypoxia on the biological behavior of Y79 retinoblastoma cells
... selective NF-κB inhibitor) to inhibit the NF-κB activity, expressions of NF-κB was measured by western blot, and the translocation of NF-κB was ...activated ...
6
Original Article Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associatedvirus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury
... of NF-κB in atherogenesis, activation of NF-κB pathway enhances regional inflammato- ry responses, damages endothelial cell func- tion and promotes endothelial cell apoptosis during ...
10
NF κB: a key role in inflammatory diseases
... that NF-κB activation plays a pathogenic role in ...synovial NF-κB binding precedes the development of clinical joint involvement in murine collagen-induced arthritis (CIA) and gradu- ally ...
6
Siegesbeckia pubescens Makino inhibits Pam3CSK4-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation
... on NF-κB and MAPKs signaling relevant proteins was measured by Western blotting analysis, while the intracellular nitric oxide (NO) generation and NF-κB/p65 nuclear translocation were ...
10
Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for Cytoskeletal Sequestration of IκBα in inflammatory signalling.
... Further analysis used the fast exchange model to simulate IL-1-induced NF-κB nuclear translocation and gene activity over longer stimulation times (Fig 3D). Results showed that, while the initial peaks were ...
18
Original Article Ligustrazine attenuates LPS-induced endothelial dysfunction by inhibiting NF-κB pathways
... suppressing NF-κB pathway activation stim- ulated by LPS through decreasing the expres- sion and phosphorylation of p65 in NF-κB path- ...of NF-κB pathways and exact mechanisms ...
7
Original Article A database and functional annotation of NF-κB target genes
... of NF-κB target ge- nes. The target genes of NF- κB involved many well-known, important pathways, such as Pathways in cancer, Apop- tosis, Jak-STAT signaling pa- thway, Acute myeloid leuke- ...
10
CCN1 induces hepatic ductular reaction through integrin αvβ5–mediated activation of NF κB
... of NF-κB in hepatic inflammation and hepatocellular carcinoma (51), relatively little is known about NF-κB functions in cholangiocytes and biliary injury ...of NF-κB increased ...
16
NF κB, stem cells and breast cancer: the links get stronger
... activates NF-κB by facilitating the nuclear localization of c-REL ...in NF-κB-dependent cascades and mediate the oncogenic potential of this IKK-related ...a NF-κB inhibitor ...
7
Original Article PSMB4 promotes glioma proliferation via NF-κB signaling
... through NF-κB activation, we blocked the NF-κB pathway in PSMB4 overexpressed cells using an NF-κB inhibitor ...of NF-κB-PSMB4 ...
11
Original Article Osteoblastic NF-κB pathway is involved in 1α, 25(OH)
... factor κB (RANK) for the induction of osteoclastogenesis and the activation of mature osteoclasts [16, ...silenced NF-κB p65 decreased the expression of RANKL in 1α, 25(OH) 2 D 3 -treated ...
9
Original Article Role of Toll-like receptor 2/NF-κB signaling pathway in the pathogenesis of allergic rhinitis
... The allergen, peptidoglycan, was used to sti- mulate the nasal mucosa in our study. The study carried out by Fu showed that TLR and NF-κB can be potential targets for the treat- ment of allergic diseases ...
8
Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
... the NF-κB signaling ...LPS-induced NF-κB activation by displacing or inhibiting NF-κB binding to its promoter regions in target genes ...the NF-κB binding cites so ...
19
Therapeutic potential of inhibition of the NF κB pathway in the treatment of inflammation and cancer
... the NF-κB pathway Flavonoids are naturally occurring phenolic com- pounds, found in plants, that exhibit a variety of biolog- ical activities, including suppression of inflammation, cancer chemoprevention, ...
9
NF κB determines localization and features of cell death in epidermis
... nuclear-localized NF-κB subunits (21) along with evidence of NF-κB target gene activation ...active NF-κB subunits p50 and p65 in transgenic epidermis fails to disrupt ...
9
Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
... body, NF-κB is highly active and specifically binds to cells, which has been proven closely related to cell growth and inflammatory reactions in the body (24, ...of NF- κB and causes an ...
9
Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... The inflammatory cytokines influences EC-SMC- MC and promotes atherosclerosis, and andro inhibits the EC-SMC-MC apoptosis by suppress- ing CXCR4 mediated inflammatory response, playing a cell protection role. All these ...
7
NF κB modulated miR 130a targets TNF α in cervical cancer cells
... promotes miR-130a expression. Numerous studies have shown that miR-130a plays an important role in cell function and carcinogenesis by targeting various genes, such as FOG-2 [36], GAX [37] and Smad4 [38] in cardio- ...
14