NF-κB, Nuclear factor-κB
Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications
... growth factor 2; HNF1A: Hepatocyte nuclear factor 1A; HNSCC: Head and neck squamos cell carcinoma; HOX10A: Homeobox- leucine zipper 10 A protein; IC: Intracellular; ICD: Intracellular domain; IGF-1: ...
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Anti inflammatory effect of Prunus yedoensis through inhibition of nuclear factor κB in macrophages
... Genistein (4′, 5, 7-trihydroxyisoflavone) is a naturally occurring flavone and the major isoflavone in soybean. Genistein has been reported to have numerous anti- oxidative and anti-cancer effects and is known to inhibit ...
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... A nuclear factor-κB (NF-κB)-dependent inflammatory pathway, which produces inflammatory cytokines, and hypoxia-in- ducible factor-1 (HIF-1)-dependent adaptive pathway ...active ...
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... and nuclear factor-κB (NF-κB) on the cell viability, apoptosis, levels of pro-inflammatory cytokines, apoptosis-related molecules, and enzymes of the Krebs ...of NF-κB ...
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Original Article Effect of acupuncture on expression levels of NF-κB, IL-1β, IL-6, and TNF-α in rats with cerebral ischemia and reperfusion
... of nuclear factor-κB (NF-κB), interleukin -1β (IL-1β), interleukin -6 (IL-6), and tumor necrosis factor-α (TNF-α) in rats with cerebral ischemia and ...and NF-κB in ...
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Dermatan sulfate activates nuclear factor κb and induces endothelial and circulating intercellular adhesion molecule 1
... The finding that intraperitoneal administration of DS augmented circulating sICAM-1 demonstrated that this GAG can function in vivo and confirmed our in vitro data that DS induces ICAM-1. Mice administered other GAGs ...
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Inhibitor of the transcription factor NF-κB, DHMEQ, enhances the effect of paclitaxel on cells of anaplastic thyroid carcinoma in vitro and in vivo
... of nuclear factor NF-κB on apo - ptotic processes in tumor cells was intensively in- vestigated in the recent ...the factor activated a group of genes whose products suppressed ...
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... important factor for preterm labor related to inflammation (COX-2 and prostaglandin) is NF- κB which is activated by numbers of inflammatory mediators, including cytokines and lipopolysaccharide ...
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Original Article Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associatedvirus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury
... a nuclear transcription factor, is known to be the key regulator for multiple functional genes expression including adhesion mole- cules, inflammatory factors, endothelial cells functional factors [22, ...
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A Nuclear Inhibitor of NF-κB Encoded by a Poxvirus
... a nuclear inhibitor of the NF- B signaling ...virulence factor M150R has been shown to colocalize with NF- B-p65 in the nuclei of TNF- ␣ -treated cells, exhibiting a punctuate pat- tern ...
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Original Article Importin 8 is involved in human periodontitis by the NF-κB pathway
... of nuclear factor kappa B (NF)-κB pp65 was detected as an indicator of NF-κB activation by immunofluorescence and western ...necrosis factor-α and interleukin-6 gene ...
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Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer
... transcription factor that induces anti- apoptotic proteins, has been considered as a key molecule for CDDP resistance ...or NF-κB expression, and ...prevents nuclear translocation of ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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The roles of the classical and alternative nuclear factor kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
... of NF- κ B in autoimmune diseases make it an important pharmaceutical ...systemic NF- κ B inhibitors are likely to have deleterious side effects, particu- larly if used for long ...of NF- κ B or the ...
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Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
... The transcriptional regulation of the changes noted are not completely understood. The increases in TF, PAI-1, and uPA are most likely to be due to the increased secretion of cytokines such as IL-1 and TNF-α, which are ...
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Original Article EGCG suppresses NF- B activation induced by gastroesophageal reflux contents in human esophageal epithelial cells
... the nuclear factor kappa-light-chain- enhancer of activated B cells (NF-κB) signaling pathway in normal human esophageal epithelial cells (HEECs) and the effect of EGCG pretreatment of cells ...
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Berberine mitigates methotrexate-induced oxidative stress and inflammation in the cerebrum of rats
... of nuclear factor-kappaB (NF-κB), inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-α) were assayed using PCR as we previously reported (Mahmoud, ...
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Anti Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis
... transcription factor, nuclear fac- tor kappa B (NF-κB) [4]. NF-κB is most frequently com- posed of a p50 and a p65 subunit and under basal conditions it is retained in the ...
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A systems biology approach to explore the dynamics and interactions of the NF-κB signalling pathway
... basal nuclear p65 does not cause the transcription of all genes, this does not exclude the possibility all ...Another factor to consider is the basal state of ...
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NF κB modulated miR 130a targets TNF α in cervical cancer cells
... Nuclear factor- κ B (NF- κ B) is a nuclear transcription fac- tor that regulates the expression of a large number of genes associated with inflammation [1,2], tissue damage and repair [3,4], ...
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