NF-κB signal pathway
Mfn2 inhibits proliferation and cell-cycle in Hela cells via Ras-NF-κB signal pathway
... the signal pathway of cell-prolifer- ation inhibition and cell-cycle arrest in Mfn2 manner in Hela cells, we detected the Ras, Myc, NF-κB p65, STAT3 proteins by western ...ERK1/2, ...
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Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
... and NF-κB p65 protein, the levels of TLR4, NF-κB and TNF-α mRAN, and the concentration of TNF-α in the model and therapy groups were significantly higher than those in the control group, ...
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Original Article A herbal extract treats type 2 diabetes mellitus effectively by down-regulating expression of CD14
... Abstract: The incidence of Type 2 diabetes mellitus (T2DM) has increased worldwide. This study investigated the effect of a herbal extract, named as Baihu decoction (BHD), in treating T2DM by using mouse adipose cells ...
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Original Article Toll-like receptor 3 (TLR3) functions as a pivotal target in latent membrane protein 1 (LMP1)-mediated nasopharyngeal carcinoma cell proliferation
... apoptosis pathway and NF-κB p65-mediated inflammatory responses by po- tentially regulating the TLR3 signal pathway, in accordance with the previous study ...
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Research on the efficacy of Celastrus Orbiculatus in suppressing TGF β1 induced epithelial mesenchymal transition by inhibiting HSP27 and TNF α induced NF κB/Snail signaling pathway in human gastric adenocarcinoma
... Nuclear and cytosolic fractions were prepared by using Nuclear and Cytoplasmic Extraction Reagents kit (Fermentas, Canada). Histone H3 and β-actin were used as markers for nuclear and cytosol proteins, respectively. ...
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1 ' Acetoxychavicol acetate inhibits growth of human oral carcinoma xenograft in mice and potentiates cisplatin effect via proinflammatory microenvironment alterations
... various signal transduction pathways involved in chemo-sensitivity such as the NF- κB pathway, explains how resistant or susceptible a can- cer type is towards drugs ...the NF-κB ...
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NF κB, stem cells and breast cancer: the links get stronger
... which NF-κB was temporally suppressed in the mammary gland ...as NF-κB activation through the canonical pathway was only suppressed in mammary epithelial cells but not in infl ammatory ...
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Original Article Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy
... the NF-κB pathway has been shown to mediate cardiac hypertrophy and maladaptive remodeling ...myocyte NF-κB p65 subunit activation in cardiac failure exacerbates cardiac remodel- ling ...
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Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model
... of NF-κB which is related to the chemo- and ...of NF-κB is oscillatory and is affected by the ...of NF-κB expression would be beneficial for determining the optimal treatment ...
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A systems biology approach to explore the dynamics and interactions of the NF-κB signalling pathway
... It is highlighted here that in order to obtain a meaningful fit to the data, and owing to the highly sensitive nature of FCS measurements, it was first necessary to sort FCS curves individually (from each 10s run) in ...
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Cirsimaritin inhibits influenza A virus replication by downregulating the NF κB signal transduction pathway
... of NF-κB, served a key role in LPS-induced inflammatory factor release from macrophages [26, ...the NF-κB promoter ...of NF-κB protein expression and the inhibition of ...
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Original Article Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/ MyD88/NF-κB signaling pathway
... which NF-κB signal- ing modulated inflammatory actions ...inhibiting NF-κB and MAPK signaling ...and NF-κB ...ERK1/2, NF-κB, Akt, p-c-JUN and JNK Figure ...
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TWEAK activation of the non-canonical NF- B signaling pathway differentially regulates melanoma and prostate cancer cell invasion
... intracellular signal transduction pathways, including the Ras/Raf/MEK/ERK pathway [21, 64], the PI3K/ Akt pathway [41], and both the canonical and non- canonical NF-κB pathways ...four ...
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Crosstalk between the canonical NF κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
... canonical NF-κB signaling and, in collaboration with basal Notch signals, induced optimal expression of Notch ...this signal was lost with Ikk2 ...fate pathway and show how these pathways can ...
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Androgen receptor activity modulates responses to cisplatin treatment in bladder cancer
... of NF-κB, which is known to involve CDDP resistance, and its phosphorylated form, as well as nuclear translocation of ...as NF-κB and phospho-NF-κB were considerably elevated, ...
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Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization
... Immunofluorescence staining and immunohistochemistry For immunofluorescence staining, wound sections were fixed in 4% paraformaldehyde and permeabilized with 0.01% Triton X-100 in PBS. The samples were incubated with ...
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Kaposi's sarcoma associated herpes virus encoded viral FLICE inhibitory protein activates transcription from HIV 1 Long Terminal Repeat via the classical NF κB pathway and functionally cooperates with Tat
... including NF-κB ...of NF-κB binding sites ...three NF-κB binding sites showed the maximum increase in vFLIP-induced HIV-1 LTR reporter activity while sub- type E, which possesses ...
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Single TNFα trimers mediating NF-κ B activation: stochastic robustness of NF-κ B signaling
... the NF- κ B signaling in single cells was analyzed both experimentally [31-34] and numerically by means of stochastic modeling [35,36], or agent-based modeling ...the NF- κ B regulatory module demands ...
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NF κB determines localization and features of cell death in epidermis
... that NF-κB can oppose cell death trig- gered by Fas and TNFα ...of NF-κB subunits in epithelial cell death, normal human keratinocytes were transduced with retroviral expres- sion vectors for ...
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Schumann, Kerstin Monika (2012): Modulation of NF-kB signaling by measles Virus P gene products. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... (A) The Paramyxoviridae family is divided into two subfamilies. The Paramyxovirinae subfamily comprises five genera: Respiroviruses, Rubulaviruses, Henipaviruses, Morbilliviruses and Avulaviruses, while the Pneumovirinae ...
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