NF-κB signaling
Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection
... Assembly of inflammasome is unique and its produc- tion induces many kinds of exogenous and endogenous signals [47]. Inflammasome is also thought to have impor- tant effects on the regulation of innate adaptive immune ...
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IKK/NF κB signaling: balancing life and death – a new approach to cancer therapy
... (IKK/NF-κB) signaling pathways play critical roles in a variety of physiological and pathological ...of NF-κB is promotion of cell survival through induction of target genes, whose ...
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Atractylenolide I modulates ovarian cancer cell mediated immunosuppression by blocking MD 2/TLR4 complex mediated MyD88/NF κB signaling in vitro
... We have demonstrated that TLR4/MD-2 complex-medi- ated activation of MyD88/NF-kB is the major mechanism for immunosuppression through induction of immu- nosuppressive molecules and generation of immuno- ...
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NF-κB signaling and vesicle transport are correlated with the reactivation of the memory trace of morphine dependence
... to NF-κB signaling and vesicular transport, because of the complex mechanism of morphine depend- ence, acetylcholine, dopamine systems, GABA signaling, and other pathways participate in this ...
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Original Article Role of Toll-like receptor 2/NF-κB signaling pathway in the pathogenesis of allergic rhinitis
... and NF-κB were observed in rats treated with PDTC (Group D) and beclomethasone (Group E) than in Gr- oup C, indicating that PDTC and beclometha- sone inhibit over-expression of TLR2 and NFκB, which resulted ...
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Sulindac activates NF-κB signaling in colon cancer cells
... the NF-κB dimers to the nucleus. NF-κB signaling can be modulated by NSAIDs in experimental models but the exact mechanism is poorly understood ...inhibit NF-κB activation ...
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Original Article miR-146a regulates inflammatory cytokines and reverses high-glucose- and high-insulin-induced insulin resistance in 3T3-L1 adipocytes by targeting Traf6 through the NF-κB signaling pathway
... (Figure 5A and 5B) but had no effect on their expression of miR-146a (Figure 5C) as com- pared with the transfection of NC-pcDNA3.0 into miR-146a mimic-transfected IR-3T3-L1 adipocytes. The results also showed that the ...
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Non canonical NF κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?
... cytokines. NF-κB is essential for normal DC differentiation, activa- tion and survival ...canonical NF-κB pathway, as well as late expression of the anti- inflammatory enzyme indoleamine ...
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Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... and improve the stability of atherosclerotic plaques [16]. In the present study, we adopted different ways to contrast how Andro control the atherosclerosis process by inhibiting the inflammatory response. ...
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Atypical IκB proteins – nuclear modulators of NF-κB signaling
... proteins suggest, that atypical IκB proteins can also bind to the other NF-κB subunits [73,78]. However, these in- teractions might be cell type specific and could depend on specific stimuli or ...
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Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
... infection, NF-κB could translocate to the nucleus and then modulate the expression of downstream target genes that participate in a number of cellular functions, including cell prolif- eration, apoptosis, ...
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Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways
... of NF-κB signaling pathway, the secretion of inflammatory factors and the up-regulation of apoptosis-related molecules are significantly aggravated by ...
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Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species mediated B cell lymphoma extra long pathway in glioblastoma multiforme
... stimulates NF-κB signaling, resulting in a B-cell lymphoma extra-long (Bcl- xL)-mediated resistance to drug-induced cell death ...[18]. NF-κB can bind directly to Bcl-xL promoter to ...
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Original Article Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanase
... UFH. NF-κB signaling path- way and MAPK P38 signaling pathway have close relationships with inflammation, and the activation of NF-κB and MAPK P38 signaling pathway was ...
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Smad7 protects against chronic aristolochic acid nephropathy in mice
... Chronic Aristolochic Acid Nephropathy (AAN) is a progressive chronic kidney disease related to herb medicine. However, treatment for chronic AAN remains ineffective. We report here that Smad7 is protective and has ...
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Adipose Derived Stem Cell Transplantation Inhibits Vascular Inflammatory Responses and Endothelial Dysfunction in Rats with Atherosclerosis
... of NF-κB p65-posi- tive cells markedly increased in AS group compared to normal and normal+ADSCs groups ...of NF-κB p65-positive cells decreased in AS+ADSCs group ...of NF-κB p65 ...
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Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4
... activate NF-κB sign- aling pathway via binding to the receptor TLR4, which is involved in noninfectious inflammatory diseases, such as tumor invasion and survival ...of NF-κB signaling ...
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Original Article Long noncoding RNA MALAT1 modulates sepsis-induced cardiac inflammation through the miR-150-5p/NF-κB axis
... of NF-κB was determined by western ...the NF-κB signaling pathway, which was consistent with that of miR-150-5p ...the NF-κB signaling pathway by upregulating ...
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Original Article Differences in gene expression profiles and signaling pathways in rhabdomyolysis-induced acute kidney injury
... and signaling pathways upon rhabdo- myolysis-induced acute kidney injury ...and NF-κB signaling ...the NF-κB, MAPK, PI3K/Akt, and apoptotic pathways are regulated in ...
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Heracleum moellendorffii roots inhibit the production of pro inflammatory mediators through the inhibition of NF κB and MAPK signaling, and activation of ROS/Nrf2/HO 1 signaling in LPS stimulated RAW264 7 cells
... of NF-κB and MAPK signaling in the inflammatory response results in excessive pro- inflammatory mediator production [11, ...of NF-κB and MAPK signaling has been con- sidered a ...
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