NF-κB signalling
Investigating IKK Dynamics in the NF κB Signalling Pathway using X Machines
... factor NF-κB is a biological com- ponent that is central to the regulation of genes involved in the innate immune ...the signalling pathway, and thus limit the effects of NF-κB within ...
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A systems biology approach to explore the dynamics and interactions of the NF-κB signalling pathway
... of NF-κB have failed to report a basal nuclear level (Ashall et ...nuclear NF-κB being interpreted as an artefact of this ...of NF-κB may simply be too low to detect using ...
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Induction and Suppression of NF-κB Signalling by a DNA Virus of Drosophila
... KV leads to downregulation of JAK-STAT and Toll and induction of Imd signalling in cell culture. We used previously established luciferase reporter-based assays to describe the effect of KV infection on the RNAi, ...
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Developmental switch in NF κB signalling required for neurite growth
... subsequent NF- κ B activation in E17 nodose neurons, we showed that PP2, a selective inhibitor of these kinases, but not a non- functional structural analogue, PP3 (Hanke et ...and NF- κ B activation ...of ...
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Aberrant Activation of NF-κB Signalling in Aggressive Lymphoid Malignancies
... Cancers of the B-cell lineage arise from malignant transformation of B cells and plasma cells (PCs) at various stages of differentiation. The majority of B-cell lymphomas and PC malignancies originate from B cells that ...
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NF κB signalling regulates the growth of neural processes in the developing PNS and CNS
... of NF- κ B target ...inhibit NF- κ B transcriptional activity selectively and efficiently by sequestering transcriptionally active NF- κ B complexes (Yeh et ...
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Computational analysis of dynamics within the Nuclear Factor-kappaB signalling system
... These data highlighted the localisation of a proportion of A20 in perinuclear speckles, consistent with studies that show A20 to co-localise with lysosomes in HeLa cells (Li et al., 2008). Li et al. used biological ...
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Original Article Osthole attenuates adjuvant-induced arthritis in rats by suppressing inflammation and oxidative stress via the SIRT1/TLR4/NF-κB pathway
... Abstract: Osthole (Ost) is a natural coumarin, mainly isolated from Cnidium monnieri. It has effects in many dis- eases, including tumours, osteoporosis, and inflammation. However, its molecular mechanism in arthritis ...
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Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization
... The NF-κB signalling pathway, which is a classic pathway that promotes the M1 polarization of macrophages, is closely related to the inflammatory response [13, ...Notch signalling, can in- ...
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Ablation of SGK1 Impairs Endothelial Cell Migration and Tube Formation Leading to Decreased Neo-Angiogenesis Following Myocardial Infarction
... downstream signalling pathways in the adult heart and to elucidate their role in cardiac neo-angiogenesis and wound healing after myocardial ...in NF-κB signalling and expression of its ...
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Curcumin attenuates MSU crystal induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
... induced inflammation, we investigated the effect of cur- cumin on IκBα, an inhibitor of NF-κB. Our results indi- cated that accelerated degradation of IκBα and elevated expression of p-p65 and p-p50 was ...
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IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance
... system, NF-κB is typically considered to be inactive, but activated in cases of injury or inflammation, consistent with its canonical function in other tissues [20, ...through NF-κB ...
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IKK/NF κB signaling: balancing life and death – a new approach to cancer therapy
... of NF-κB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous ...cells. NF-κB can also prevent ...
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Original Article Ruscogenin exerts beneficial effects on monocrotaline-induced pulmonary hypertension by inhibiting NF-κB expression
... the NF-κB signaling path- way ...of NF-κB p65, which indicates that ruscogenin may be used as a potential therapeutic agent for acute lung injury (ALI) or sepsis ...
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Immunohistochemical Expression of Nuclear Factor – Kappa B in Oral Squamous Cell Carcinoma, Oral Submucous Fibrosis and Normal Mucosa
... of NF- κ B in oncogenic transformation was derived from the fact that v - Rel, a highly oncogenic retroviral homologue of c – Rel leads to carcinogenesis of avian lymphoid cells 41,45 ...of NF – κ B ...
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Therapeutic potential of inhibition of the NF κB pathway in the treatment of inflammation and cancer
... the NF-κB pathway Flavonoids are naturally occurring phenolic com- pounds, found in plants, that exhibit a variety of biolog- ical activities, including suppression of inflammation, cancer chemoprevention, ...
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NF κB: a key role in inflammatory diseases
... IL-1–induced NF-κB activation and therefore represents a potential target for strategies aimed at inhibiting proinflamma- tory gene expression for the treatment of a variety of inflammatory disorders, ...
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NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
... 3: NF-κB/RelA is involved in FF-induced inhibition of ...of NF-κB/RelA but also induced dissociation of NF-κB/RelA and HIF1α in the ...inhibited NF-κB/RelA ...
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NF- B signaling mediates acquired resistance after PARP inhibition
... Figure 3B and 3C). Therefore, we have performed further experiments using these settings. In UWB1.289 cells, ~7.5 percent of cells have nuclear accumulation of p65 in parental cells. In contrast, ~15.2 or ~13.2 percent ...
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Control of oncogenesis and cancer therapy resistance by the transcription factor NF κB
... of NF-κB in onco- genesis comes from experiments in which the NF- κ B pathway has been directly ...of NF- κ B by expression of a modified form of I κ B α (super- repressor IκBα) (15) or by a ...
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