NK Cell Activation
Plasmid Vector-Linked Maturation of Natural Killer (NK) Cells Is Coupled to Antigen-Dependent NK Cell Activation during DNA-Based Immunization in Mice
... for NK cell activation in vivo during Leishmania major infection ...of NK cells but may rather act in synergy with DC to induce the functional maturation of NK cells in lymph ...of ...
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Slaying the Trojan Horse: Natural Killer Cells Exhibit Robust Anti-HIV-1 Antibody-Dependent Activation and Cytolysis against Allogeneic T Cells
... block cell-to-cell trans- mission of HIV-1, other HIV-1-specific neutralizing antibodies fail to efficiently do so ...Ab-dependent NK cell activation against allogeneic primary ...
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Cytokine-Mediated Activation of NK Cells during Viral Infection
... Although NK cells have traditionally been classified as part of the innate immune system, recent studies suggest that they may also exhibit some characteristics associated with adaptive immu- ...memory-like ...
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Heparan sulfate mimetic PG545 mediated antilymphoma effects require TLR9 dependent NK cell activation
... on NK cell activation and that NK cell activation by PG545 requires ...TLR9 activation through the elevation of the TLR9 ligand CpG in ...PG545-mediated NK ...
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Variation in Adenovirus Transgene Expression between BALB/c and C57BL/6 Mice Is Associated with Differences in Interleukin-12 and Gamma Interferon Production and NK Cell Activation
... NKG2 activation receptor (3), was observed to increase around day 7 postinfec- ...in NK cell activation but also in macrophage production of TNF-␣ (5, 10, 21) and nitric ...of NK cells ...
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Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques
... macaque NK cells to express both CD107a and gamma interferon (IFN- ␥ ) in the presence of HA proteins from either sH1N1 or H1N1pdm ...(ADCC)-mediated NK cell activation dimin- ished in titer ...
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FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV
... HIV-specific NK cell activation in presence of anti-HIV antibodies was used as a surrogate marker for HIV-specific ADCC response by number of studies [3, 4, ...specific NK cell (ADCC) ...
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Contribution of NK Cell Education to both Direct and Anti-HIV-1 Antibody-Dependent NK Cell Functions
... Basic NK cell biology is likely key to understanding the contribu- tions that anti-HIV-1 antibody-dependent NK cell activation and cytolysis make to HIV-1 susceptibility and disease ...
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What lies beneath: antibody dependent natural killer cell activation by antibodies to internal influenza virus proteins
... the NK cell Fc γ RIIIa (CD16a) receptor interacts with the Fc region of IgG Abs bound to their viral antigens (Ags) on the surface of virally infected ...to NK cell activation, which ...
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Interleukin-2 from Adaptive T Cells Enhances Natural Killer Cell Activity against Human Cytomegalovirus-Infected Macrophages
... that NK cells are equally activated by infected M1 and M2 ...T cell proliferation from HCMV-seropos- itive donors ...of NK cells described in our ...the NK cells’ activity in response to ...
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T cell activation promotes tumorigenesis in inflammation associated cancer
... The second transgene expresses firefly luciferase (LUC) under the regulation of the HTLV-1 LTR. When mice carry both the LTR-LUC and GZB TAX transgenes (TAX-LUC mice), the events associated with the expression of Tax, ...
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Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin
... including NK cells is important for its success as a viral pathogen of humans and ...animals. NK cells encounter influenza virus within the microenvironment of infected ...on NK cell ...human ...
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NK1 1 receptor ligation or tumour interactions prime NK cells for IL2 mediated metabolic and functional responses
... of NK cells. However, strikingly NK1.1 mediated activation of NK cells results in robust CD25 ...that NK cells have mechanisms that would allow them to function alongside the adaptive immune ...
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Liver resident NK cells confer adaptive immunity in skin contact inflammation
... CHS. On days 0 and 1, the shaved abdominal skin of mice was painted with 50 μl 5% OXA (Sigma-Aldrich) in a solution of acetone/methanol (1:1) or 0.5% FITC (Sigma-Aldrich) in dibutylphthalate. These mice were used as ...
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Intravenous ascorbic acid as an adjuvant to interleukin 2 immunotherapy
... The concept of AA deficiency subsequent to IL-2 ther- apy was reported previously by another group. Marcus et al evaluated 11 advanced cancer patients suffering from melanoma, renal cell carcinoma and colon cancer ...
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Original Article Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus
... [4]. NK cells affect immune responses by killing target cells directly or by producing pro-inflammatory and regulatory cytokines ...circulating NK cells are significantly lower in SLE patients and NK ...
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Potential Role of Interleukin-18 in the Immunopathogenesis of AIDS: Involvement in Fratricidal Killing of NK Cells
... between NK cell numbers and the levels of the circulating IL-18 in HIV-infected ...of NK cells— i.e., CD3 ⫺ CD16 ⫹ , CD3 ⫺ CD56 ⫹ , and CD16 ⫹ CD56 ⫹ NK cells—showed almost equally strong ...
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Identification of NK Cell Subpopulations That Differentiate HIV-Infected Subject Cohorts with Diverse Levels of Virus Control
... Dimensionality reduction followed by k-means clustering revealed NK cell subpopulations that differentiated multiple HIV-infected subject groups. As a distinct approach, we performed supervised and ...
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The Human Cytomegalovirus Protein UL148A Downregulates the NK Cell-Activating Ligand MICA To Avoid NK Cell Attack
... by NK cells, since they are inhibited by MHC class I proteins ...of NK cells are necessary for HCMV to successfully ...target NK cell ligands in general and, specifically, ligands of the NKG2D ...
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Maintenance therapy with histamine plus IL-2 induces a striking expansion of two CD56 bright NK cell subpopulations in patients with acute myeloid leukemia and supports their activation
... labeled NK cell subsets were then again combined and a complete PBMC culture reconstituted as described in Materials and Methods and depicted in ...target cell line U937 in a 5:1 effector:target ...
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