NKG2D Ligands
Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity.
... The cytoplasmic and transmembrane domains of UL16 clearly play a role in intracellular traffic and intracellular re- tention. When these domains were replaced with those of the IL-4R (IL-4R/UL16), there was detectable ...
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Potential therapeutic strategy for gastric cancer peritoneal metastasis by NKG2D ligands-specific T cells
... of NKG2D to the CD28 and CD3zeta chain intracellular domains to target gastric cancers that expressed NKG2D ...of NKG2D ligands including MICA, MICB, and ULBP1–3 in a gastric cancer cell line ...
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Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B
... of ligands for the key NK cell-activating receptor ...the NKG2D ligands, major histocompatibility complex class I chain-related proteins A and B (MICA and MICB), their expression on the cell surface ...
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Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
... H uman immunodeficiency virus type 1 (HIV-1) has developed multiple mechanisms to evade the immune system and establish a chronic infection. Several of these strategies are mediated by viral accessory proteins, including ...
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Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis
... of NKG2D ligands, in particular MICA and MICB, in all cell ...on NKG2D-NKG2D ligand interactions, since blocking of NKG2D abrogated ...
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Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma via the NKG2D-ligands recognition
... In this study, time-lapse video microscopy fully revealed that when CIK cells were in vitro co-cultured with them, each of cancer cells, GFP-labeled or PKH26labeled putative CSCs, or tum[r] ...
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Oncogenes in immune cells as potential therapeutic targets
... lesions. NKG2D is an activating receptor expressed on human and mouse NK cells that rec- ognizes a diverse family of ...of NKG2D activates the cytotoxic activity of NK cells against cells expressing these ...
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Expression and prognostic significance of unique ULBPs in pancreatic cancer
... ments have shown that NKG2D ligands expression is hetero- geneous and can be influenced by stress, posttranscriptional factors, and other stimuli, such as DNA damage. To date, the mechanism of action of ...
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Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib mediated immunoregulation
... restore NKG2D ligands and NKG2D interaction, and inhibit stat3 expression, we did not find significant improvement on NK cells cytotoxicity to A549 cells with wild type EGFR, while there was signifi- ...
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Human Herpesvirus 6B Downregulates Expression of Activating Ligands during Lytic Infection To Escape Elimination by Natural Killer Cells
... these ligands is relatively low when balanced against the major downregulation of MICB, ULBP1, and ULBP3, so the net result leads to inhibition and there is no need to impair additional ...an NKG2D fu- sion ...
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Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD like disease
... of NKG2D ligands leads to the disruption of the alveolar architecture by CTL-mediated apoptosis of pulmo- nary epithelial ...that NKG2D-bearing cells were abun- dant in the lung and that NKG2D ...
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Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile Onset Systemic Lupus Erythematosus
... the NKG2D ligands MICA and MICB, suggesting that kidney and/or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D + CD4 T cell population expansions in this ...
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Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer
... for NKG2D-mediated activation of cytolytic effector cells in tumor ...of NKG2D-mediated immunity for human ...surface NKG2D expression on NK cells and/or CTLs. Such a deficiency in ...
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Crystal Structure of the Cowpox Virus-Encoded NKG2D Ligand OMCP
... (1). NKG2D is an activating receptor on NK cells and a costimulatory receptor on T cells ...sequence-diverse NKG2D ligands (NKG2DLs), respectively (8). Engagement of NKG2D by ligands ...
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Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R from HIV-1 Primary Isolates
... specific ligands of the NKG2D (natural killer [NK] group 2, member D) receptor on T cells in a Vpr-dependent manner (24, ...by NKG2D receptor-expressing NK cells (24, ...
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1-s2.0-S0092867419311262-main.pdf
... cognate ligands and receptors, has consistently transformed the understanding of human biology (Civelli et ...some ligands to preferentially activate one signaling pathway at the expense of others ...
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Abnormal expression levels of sMICA and NKG2D are correlated with poor prognosis in pancreatic cancer
... and NKG2D in pancreatic carcinoma and paracarcinoma tissues from 70 patients with pancreatic ...whereas NKG2D expression was significantly ...high NKG2D expression was significantly associated with ...
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Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia
... and NKG2D-Fc-ADCC, NKG2D-CD16 mediated the most potent effects of all three on short-term ...lysis. NKG2D-CD3 required longer times to unravel its therapeutic potential, which after longer times of ...
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Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells
... Agents that cause genotoxic stress or DNA- replication inhibitors have been recently shown to activate the DNA damage response (DDR) as well as to increase the expression of stress-induced NKG2D and DNAX accessory ...
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trans Bis(4 aminopyridine κN)bis(succinimidato κN)copper(II) dihydrate
... show flexible coordination geometries and electronic states (Hathaway & Billing, 1970). We have reported that the tetragonal Jahn–Teller distortion can be affected by the external temperature or light irradiation for ...
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