NMO-IgG
Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury
... The NMO pathology seen at 5 days after intracerebral needle injury in seropositive rats was around the needle track in an area corresponding to that of early NMO- IgG ...of NMO patient-derived ...
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Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis
... with NMO-IgG does not require overt depletion of astrocytes or of AQP4 from lesions but does not rule out AQP4 ...term NMO-IgG exposure in rat models has not yet been ...of ...
9
Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD
... Fig. 4 Axonal spheroids/end bulbs in retina, papilla, and optic nerve. Sections through the optic nerve head (a, b), ganglionic cell layer (c-e, consecutive sections) and retinal nerve fiber layer (f) were reacted with ...
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Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats
... The effects of IL-1 β on endothelial cells of the BBB Cytokines/chemokines have only short half-life times [7] and are rapidly redistributed from the parenchyma to the vasculature [8]. Yet, only IL-1β was able to trigger ...
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A new M23-based ELISA assay for anti-aquaporin 4 autoantibodies: diagnostic accuracy and clinical correlation
... of NMO-IgG [31] has AQP4- M23 become more widely used as the target antigen ...high-risk NMO patients, they chose to use the M23 isoform, because it increased the signal- to-noise ...
7
NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG
... g/mL NMO IgG (NMO) or CON IgG (CON) were probed by immunoblot for levels of ...with NMO IgG as compared to UNT and CON IgG-stimulated samples, consistent with the ...
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The role of anti aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica
... to NMO. The prevalence of anti- AQP4 antibodies in NMO patients ranged from 50– 60 % [3, ...However, NMO-IgG is not restricted to these patients fulfilling all criteria for a definite ...
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Evidence-based guideline: Clinical evaluation and treatment of transverse myelitisReport of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
... of NMO-IgG antibodies (aquaporin-4–specific antibodies) should be considered useful in determining increased TM recur- rence ...determining NMO vs ...to NMO to decrease the number of ...
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Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica
... of NMO to investigate the role of eosino- phils in NMO pathogenesis and the therapeutic potential of eosinophil ...of NMO autoantibody ...mechanism. NMO pathology was produced in ...
12
Update on neuromyelitis optica: natural history and management
... the NMO-IgG (anti AQP4) antibody, it has become evident that the spectrum of the disease is wider than previously thought and not limited to the optic nerve and the spinal ...clinical NMO have ...
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Interferon-β-related tumefactive brain lesion in a Caucasian patient with neuromyelitis optica and clinical stabilization with tocilizumab
... in NMO, even following treatment with rituximab ...that NMO is often characterized by very long periods free of any relapses, the suggested success of tocilizumab in our patient needs to be followed ...in ...
5
Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate
... novel IgG serum reactivity present in around 60 to 80% of pa- tients with NMO (termed NMO-IgG) [5,6], which was subsequently shown to target aquaporin-4 (AQP4), the most abundant water channel ...
7
Human leukocyte antigens‑immunogenetics of neuromyelitis optica or Devic’s disease and the impact on the immunopathogenesis, diagnosis and treatment: a critical review
... or NMO‑immunoglobulin G (IgG). Researches trying to correlate NMO with specific human leukocyte antigen (HLA) alleles took place in a limited extend in the last few ...of NMO, in the ...
7
Nemo is an inducible antagonist of Wingless signaling during Drosophila wing development
... affect nmo expression, we generated UAS-Axin flip-out clones and examined the effects on nmo-lacZ ...6G,H), nmo expression is suppressed ...of nmo expression ...boundary nmo but also ...
10
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin
... The limitations include a potential referral bias due to the possibility that patients with ON and/or myelitis may have been preferentially referred for MOG-IgG test- ing as a consequence of the close association ...
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MRI characteristics of neuromyelitis optica spectrum disorderAn international update
... Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti– aquaporin-4 antibody ...
11
IgG Charge
... data for these mAbs in physiological solvents, and it is not known whether their charge falls into the 43.. range observed for normal human IgGs.[r] ...
14
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
... MOG- IgG-positive ON and/or myelitis meet the 2015 inter- national diagnostic criteria for NMOSD, others do not; this is problematic from a nosological point of view, as- suming that the same immunopathogenesis ...
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Epstein Barr Virus Antibodies in Kawasaki Disease
... antigens IgG and IgM (anti-VCA IgG and IgM) were examined by indirect fluorescent antibody assay (Bion Enter- prises ...antigen IgG (anti-EADR IgG) was evaluated by immunofluorescence assay ...
5
IgG glycoforms in arthritis
... serum IgG GO levels in five month old arthritic mice compared to control mice was observed (as seen in chapter ...secreted IgG GO ...of IgG autoantibody producing B-cells in the lymph nodes and ...
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