Nodal signaling
A role for Vg1/Nodal signaling in specification of the intermediate mesoderm
... of Nodal-like signaling on IM and PM gene expression are perhaps surprising, as some previous reports have characterized Nodal and related signals as dorsalizing factors that promote dorsal/medial ...
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Endogenous Nodal signaling regulates germ cell potency during mammalian testis development
... of Nodal was to suppress meiosis. However, because Nodal expression is reduced, not ablated, in our model, a role in suppressing meiosis can not be ...whether Nodal suppresses meiosis in ...of ...
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The Nodal signaling pathway controls left-right asymmetric development in amphioxus
... whether Nodal signaling also controls the LR asymmetrical distribution of CNS neurons, we used the expression pattern of the pan-neuronal marker Hu/Elav to examine the distribution of post-mitotic neurons ...
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Nodal signaling regulates specification of ascidian peripheral neurons through control of the BMP signal
... BMP signaling is reportedly involved in neural-epidermal segregation and specification of dorsal nervous system containing PNS (Dorfman and Shilo, 2001; Lu et ...BMP signaling is required for PNS formation ...
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Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation
... of Nodal and is normally expressed only on the left lateral plate mesoderm (LPM) at ...a Nodal heterozygous mutation, such that Pitx2 was restricted to one side of the LPM ...these Nodal rescue ...
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Nuclear movement regulated by non Smad Nodal signaling via JNK is associated with Smad signaling during zebrafish endoderm specification
... Erk, p38 and JNK. Previous studies have revealed that MAPKs phosphorylate the linker region of Smad2/3 by activation of TGF β , which, in turn, blocks the nuclear translocation of Smad2/3 (Massague, 2003; Mori et al., ...
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Zygotic VegT is required for Xenopus paraxial mesoderm formation and is regulated by Nodal signaling and Eomesodermin
... and Nodal signaling regulate the expression of zVegT and the formation of paraxial mesoderm formation in Xenopus ...then Nodal signaling subsequently induces the expression of Eomes, and ...
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Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation
... transcriptional complexes negatively regulates TGF-  signaling. For instance, the oncoprotein Ski, a transcriptional co-repressor, competes with R-Smads for association with Smad4, disrupting the formation of a ...
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Xantivin suppresses the activity of EGF CFC genes to regulate nodal signaling
... that nodal signaling controls its expression (Erter et ...by nodal signaling, suggesting that Xatv mRNA is a good marker to test for the activation of nodal signaling (Cheng et ...
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The Vg1 related protein Gdf3 acts in a Nodal signaling pathway in the pre gastrulation mouse embryo
... for Nodal, which plays crucial roles in AP patterning, formation of mesoderm, definitive endoderm and axial mesendoderm, and specification of the left- right axis (reviewed by Schier, 2003; Schier and Shen, 2000; ...
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Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation
... of Nodal signaling, no endoderm- or mesoderm-derived organs or tissues can develop in zebrafish embryos (Feldman et ...two Nodal factors (Squint and Cyclops; also known as Nodal-related 1 and ...
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Nodal signaling and the zebrafish organizer
... for Nodal signaling and Boz in the formation of dorsal ...and Nodal-related signals. Consistent with this, Nodal-related signals are not required for chordin expression (Gritsman et ...and ...
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Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion
... of Nodal resulted in an ~12-fold increase in luciferase activity ...potentiated Nodal signaling ...on Nodal signaling ...Smad5 signaling tempers Nodal signaling, ...
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Reversal of left right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos
... the Nodal signaling pathway, might be ...for Nodal and Cerl2 expression indicated that the expression of Nodal was markedly greater than that of Cerl2 in the posterior region of the node of ...
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Nodal signaling promotes vasculogenic mimicry formation in breast cancer via the Smad2/3 pathway
... that Nodal plays an essential role in promoting VM formation in breast cancer ...culture, Nodal up-regulation in MCF-7 cells, which do not form VM channels, was shown to facilitate the formation of channel- ...
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Nodal signaling: developmental roles and regulation
... for Nodal that confer specificity for the type I receptor ALK4 through protein interactions (Yan et ...the Nodal ligands cyc and sqt, whereas the expression of Activin, but not Nodal, can rescue the ...
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Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo
... of Nodal expression in the left lateral plate mesoderm, but not in the node region (95%, n=20, ...side, Nodal was never ectopically induced (n=18, ...the Nodal signal. In addition, the expression of ...
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Axial patterning interactions in the sea urchin embryo: suppression of nodal by Wnt1 signaling
... Although all of these observations strongly suggest that loss of Wnt1 causes cells in the PVC to change fates, an alternative interpretation for the loss of PVC markers is that cells in this region are lost in Wnt1 ...
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Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors
... of Nodal signaling genes was detected in biopsies containing CIS and the NS tumors EC and YST (Spiller et ...that Nodal signaling in this context is highly dependent on the stem cell niche of ...
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Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo
... crucial signaling molecules, FGF8 and ...Notch signaling, and also induces the lateralmost neural fate (Hudson et ...these signaling pathways require either direct cell-cell contact (Notch) or act ...
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