Non neoplastic lesions:

Top PDF Non neoplastic lesions::

Neoplastic and non-neoplastic lesions of the hands and feet of dogs (2003-2016)

Neoplastic and non-neoplastic lesions of the hands and feet of dogs (2003-2016)

Hands and feet of dogs are commonly affected by neoplastic and non-neoplastic lesions. These lesions may commonly present poor clinical or histopathological prognosis and amputation tends to be the treatment of choice. Previous studies regarding the prevalence and the clinicopathological aspects of digital changes in dogs have been performed abroad, with no similar investigations in Brazil. The aim of this manuscript was to perform a histopathological study to characterize hands and feet lesions of dogs from Brazil.Tissue samples from 105 tumor-like lesions of dogs hands and feet were used in this study. The samples came from three Brazilian veterinary diagnostic laboratories and were collected between 2003 and 2016. All specimens were fixed in 10% buffered formalin, and routinely processed for paraffin embedding and hematoxylin-eosin staining. Additionally, toluidine blue, Brown and Breen, periodic acid Schiff (PAS), Grocott Methenamine Silver (GMS) and Ziehl Neelsen were used in selected cases. Immunohistochemistry using anti-Leishmania spp., anti-CD117, anti-CD79, anti-CD3, anti-Melan A, anti-lysozyme, anti-Pancytokeratin AE1/AE3, and anti-vimentin antibodies were also performed. Neoplasia (62.9%) was the most frequently found lesion, followed by inflammation (19%), and other changes (18.1%). Among the neoplasms, 40.9% were mesenchymal, 39.4% epithelial, and 19.7% round cells. All round cells and most of the epithelial and mesenchymal neoplasms were malignant. There was no difference between males and females regarding neoplasia prevalence. Labrador Retriever, Schnauzer, Teckel, mongrel, German Shepherd, Rottweiler, and Pit Bull were the most frequently affected breeds. Fila Brasileiro (aka Brazilian Mastiff), Pit Bull and Schnauzer had higher incidence of mesenchymal, epithelial, and round cells neoplasms, respectively. Inflammation was more commonly observed in the Labrador Retriever and other changes were more commonly in Teckel, Labrador Retriever, and mongrel dogs. Medium age and weight were 8.4 years and 28.5 kg, respectively. Medium diameter of the tumor-like lesions was 2.5 cm and the neoplastic lesions presented higher averages. Lesions were mainly in yellow-coated dogs. Incisional
Show more

11 Read more

Clinical Correlation of Upper Gastrointestinal Endoscopic Biopsies with Histopathological Findings and To Study the Histopathological Profile of Various Neoplastic and Non-Neoplastic Lesions

Clinical Correlation of Upper Gastrointestinal Endoscopic Biopsies with Histopathological Findings and To Study the Histopathological Profile of Various Neoplastic and Non-Neoplastic Lesions

Results and Conclusion Among 115 cases studied, non-neoplastic lesions were more common in gastrointestinal pathological lesions. The prevalence of gastrointestinal pathol- ogy is more common among males around the fourth and fifth decades of life. Dyspepsia and dysphagia were the most significant presenting clinical features. Helicobacter pylori association was demonstrable in nearly one-fourth of chronic gastritis cases. In gas- tric region, adenocarcinoma was the commonest neoplastic conditions, whereas in the oesophagus, squamous cell carcinoma is the predominant. In duodenum, inflammatory lesions are more common than malignancy.
Show more

5 Read more

A Clinico-Morphological Spectrum of the Non Neoplastic Lesions of the Uterine Cervix at AJ Hospital, Mangalore

A Clinico-Morphological Spectrum of the Non Neoplastic Lesions of the Uterine Cervix at AJ Hospital, Mangalore

ArAvind PAlliPAdy, SAndyA illAnthody, rAShmi vAidyA, ZulfikAr Ahmed, rithin SuvArnA, GAuri metkAr AbsTRACT Background and objectives: Cervices from hysterectomies and biopsies constitute the majority of gynaecological specimens which are received in the department of histopathology and non-neoplastic lesions form the huge chunk of diagnosis among them. However, there are many lesions that appear to be exuberant and can be misdiagnosed to be malignant. On the basis of this, a detailed histomorphological study of the non- neoplastic lesions of the cervix was taken up .
Show more

5 Read more

A study of incidence of columnar cell lesions in neoplastic and non –neoplastic lesions of breast

A study of incidence of columnar cell lesions in neoplastic and non –neoplastic lesions of breast

methods: This is an observational study conducted in the Department of Pathology,Gandhi hospitalfrom January 2016 to December 2017.H&E stained sections of Neoplastic and Non-Neoplastic breast lesions were reviewed and associated Columnar cell changes were evaluated.Results:Total200 breast lesions were studiedout of which 134 showed Columnar cell lesions. 90% cases of fibrocystic disease and 60% of fibroadenoma cases were associated with CCL and the predominant type of lesionis Columnar cell change. 80% cases of Ductal carcinoma insituand 40% of Infiltrative duct cell carcinoma cases showed CCL and the common lesion is Columnar cell hyperplasia without atypia.Conclusion: Columnar cell lesions were observed in both Neoplastic and Non-Neoplastic breast lesions. Based on previous observational studies cancer risk associated with CCL is only mild on long term follow up. However detection of CCL in biopsy should prompt additional scrutiny for other pathological changes.
Show more

5 Read more

Galectin 3 immunohistochemical expression in neoplastic and non neoplastic lesions of thyroid

Galectin 3 immunohistochemical expression in neoplastic and non neoplastic lesions of thyroid

3 IMMUNOHISTOCHEMICAL EXPRESSION IN NEOPLASTIC AND NON-NEOPLASTIC Madhu Mati Goel, 1 Malti Kumari, , Gangtok, Sikkim, India Thyroid cancer is the most common endocrine malignancy. The galectin-3 is a member an important role in cellular growth, differentiation and -3 in neoplastic and non-neoplastic In this observational study we evaluated gal-3 expression in spectrum of 67 diagnosed sample including as follows: 30 PTC (included 9 classical variant, 18 follicular, 02 solid variant, 01 micropapillary), 10 FTC, 14 benign neoplasm (including follicular adenoma and hurthle cell adenoma) and 13 non neoplastic (includes hyperplasia and inflammatory lesions) cases. To rule out subjective differences during IHC, a 3- observe evaluation method was The statistical analysis was done using SPSS (statistical package for social 3 expression was significantly higher in malignant thyroid neoplasm as compared to Maximum number of malignant cases were aged between 41 to 50 For scoring, it was observed that as compared to non- 3 to be used as adjunct for aiding thyroid cancer diagnosis.
Show more

6 Read more

A study of non neoplastic lesions of larynx causing voice disorders

A study of non neoplastic lesions of larynx causing voice disorders

44 Abstract Rheumatic mitral stenosis is prevalent in this part of the world and it gives rise to wide array of manifestations. However, hoarseness of voice secondary to recurrent laryngeal nerve paralysis (Ortner’s syndrome) is an uncommon manifestation. This case illustrates an uncommon presentation in a common disease. A 29-yearold lady presented with a 2-year history of hoarseness of voice. Physical examination revealed a mid-diastolic murmur and left vocal cord paralysis. Echocardiography confirmed mitral stenosis with pulmonary hypertension. She underwent percutaneous mitral balloon valvotomy in 1991 with return of normal speech after a few months. The recurrent laryngeal nerve paralysis is mainly due to the compression by an enlarged pulmonary artery as initially thought. This complication is rarely seen nowadays due to greater awareness of the disease and earlier intervention. With the advent of percutaneous transvenous mitral valvotomy in the nineties, effective non-surgical intervention is plausible.
Show more

79 Read more

Bone Pathology I Non-Neoplastic Lesions of Bones and Joints

Bone Pathology I Non-Neoplastic Lesions of Bones and Joints

Fibrous Dysplasia: Fibrous dysplasia is a non-neoplastic condition that can present in 2 forms: monostotic and polyostotic. The monostotic variety is usually seen in older children and young adults. It most commonly involves the rib, femur and tibia. The disease may be asymptomatic or can lead to a fracture. The less common, polyostotic variety is characterized by unilateral distribution usually associated with endocrine dysfunction, precocious puberty in females and areas of cutaneous hyperpigmentation (McCune-Albright syndrome). This syndrome is the result of a somatic mutation of the c-fos oncogene in affected tissues that results in the activation of the signal-transduction pathway that generates cyclic AMP.
Show more

5 Read more

Abstract Background: Neck swellings include various non-neoplastic and neoplastic lesions of lymph node, salivary

Abstract Background: Neck swellings include various non-neoplastic and neoplastic lesions of lymph node, salivary

Conclusion: FNAC is a simple, quick, inexpensive and minimally invasive technique to diagnose neck swellings. It can obviate the need for surgery in some of non-neoplastic lesions. Thus, FNAC can be recommended as a first line investigation in diagnosis of neck swellings. Keywords: FNAC, Cytology, Neck swellings.

6 Read more

Clinicopathological Study of Non-Neoplastic and Neoplastic Lesions of Larynx Chaitanya V 1, Nikethan B *2

Clinicopathological Study of Non-Neoplastic and Neoplastic Lesions of Larynx Chaitanya V 1, Nikethan B *2

factors for this disease. Occupational risk factors that include exposure to asbestos have also been described although dust exposures other than asbestos have been historically understudied [3]. The larynx is divided into the supraglottic, glottis and subglottis based on anatomical location. Tumors of the larynx can be divided into benign or malignant. Laryngeal granulomas, vocal cord nodules, and vocal cord polyps are tumor-like (non-neoplastic) lesions of the larynx. Benign laryngeal tumors include a large number of lesions such as papillomas, hemangiomas, fibromas, chondromas, myxomas, and neurofibromas. About 95% of laryngeal carcinomas are typical squamous cell tumors. Rarely adenocarcinomas are seen to arise from larynx, presumably arising from mucous glands [4].
Show more

6 Read more

Inphase Opposed Phase Imaging of
Bone Marrow Differentiating Neoplastic Lesions from
Non Neo Plastic Lesions.

Inphase Opposed Phase Imaging of Bone Marrow Differentiating Neoplastic Lesions from Non Neo Plastic Lesions.

DECLARATION I Dr.N.SUNDARESWARAN, solemnly declare that this dissertation entitled, “INPHASE OPPOSED IMAGING OF BONE MARROW DIFFERENTIATING NEOPLASTIC LESIONS FROM NON NEOPLASTIC LESIONS” is a bonafide work done by me at the Barnard Institute of Radiology, Madras Medical College and Government General Hospital during the period 2008 – 2010 under the guidance and supervision of the Director, Barnard Institute of Radiology of Madras Medical College and Government General Hospital, Profes- sor K. Vanitha, M.D., D.M.R.D., D.R.M., This dissertation is submit- ted to The Tamil Nadu Dr. M.G.R Medical University, towards partial fulfillment of requirement for the award of M.D. Degree Radiodiagnosis.
Show more

79 Read more

Cyto-Histological Correlation of Thyroid Lesions with Estrogen and Progesterone Receptor Status on Neoplastic Lesions

Cyto-Histological Correlation of Thyroid Lesions with Estrogen and Progesterone Receptor Status on Neoplastic Lesions

Key Words: Thyroid, FNAC, Cyto-Histological Correlation, Estrogen receptor, Progesterone receptor ABSTRACT Introduction: Thyroid nodules are common clinical findings, they are more common in women and this incidence increases with age, a history of radiation exposure and with a diet which contains goitrogenic material. Fine needle aspiration cytology (FNAC) is an established technique for the investigation of thyroid nodules. The aim of the present study was to establish a correlation between the cytological features and the histomorphology of various neoplastic and non-neoplastic lesions. Secondly, we aimed to analyze the oestrogen receptor (ER) and the progesterone receptor (PR) status in malignant thyroid tumours.
Show more

5 Read more

Original Article Immunohistochemical expression of IMP3 and p53 in inflammatory lesions and neoplastic lesions of the gastric mucosa

Original Article Immunohistochemical expression of IMP3 and p53 in inflammatory lesions and neoplastic lesions of the gastric mucosa

Abstract: Aim: Expression of the oncofetal protein insulin like growth factor II messenger ribonucleic acid binding protein 3 (IMP3) has been shown to differentiate between benign and malignant lesions in several tissues. Our aim was to assess the immunohistochemical expression of IMP3 in inflammatory and neoplastic lesions of the gastric mucosa and to determine whether IMP3, alone or in combination with p53, could be used for identifying neoplasia of the gastric mucosa. Methods: IMP3 and p53 immunohistochemistry was performed on 57 cases of gastritis, 28 cases of dysplasia of the gastric mucosa and 63 cases of gastric carcinomas. Focal IMP3 positivity was detected in 86% of non-neoplastic lesions of the gastric mucosa. Using a simple product score (PS), 96% of non-neoplastic lesions of the gastric mucosa were assessed as IMP3(PS) negative. None of the low-grade dysplasia but 83% of high-grade dysplasia were IMP3(PS) positive. Gastric carcinomas showed IMP3(PS) positivity in 65%. Adding p53 to the diagnostic panel increased sensitivity significantly. Conclusion: High-grade dysplasia and gastric carcinomas can be distinguished from low-grade dysplasia and inflammatory lesions of the gastric mucosa with a high specificity and good sensitivity using a combination of the immunohistochemical markers IMP3 and p53.
Show more

11 Read more

THE NON-NEOPLASTIC CYSTSDISEASE OF THE OVARY AND ITS EFFECTIVE DIAGNOSIS

THE NON-NEOPLASTIC CYSTSDISEASE OF THE OVARY AND ITS EFFECTIVE DIAGNOSIS

neoplastic cysts. 1. OVERVIEW The ovary is a complex structure from an embryological, anatomic and functional outlook of view. It differs in volume at the time of ovulation, pregnancy[1], and menopause. Ovaries have remarkable protection from diseases. Ovary can be the seat of an extensive number of non- neoplastic lesions. Nonneoplastic lesions of the ovary often form a pelvic mass and frequently are related with abnormal hormone related manifestations, therefore conceivably mimicking an ovarian neoplasm on clinical examination, at the time of surgery. Many happen in the conceptive years and may meddle with fertility. In the
Show more

8 Read more

High sensitivity analysis of BRAF mutations in neoplastic and non-neoplastic thyroid lesions

High sensitivity analysis of BRAF mutations in neoplastic and non-neoplastic thyroid lesions

44 oncogenic BRAF generated by mutating the gatekeeper residue, sorafenib still inhibited the growth of tumors driven by the mutant protein [219]. Therefore, the failure of sorafenib to result in significant objective responses in BRAF-mutant melanoma in clinical trials has been interpreted as consistent with the non-BRAF mediated mechanism of action of the drug [220]. It was later shown that sorafenib mediates antitumor effects in renal cell cancer (RCC) independently of its ability to block BRAF V600E signaling [219]. It was eventually approved for the treatment of RCC and unresectable hepatocellular carcinoma (HCC). The efficacy in these cancers is believed to be due to inhibition of other kinases such as VEGFR2, KIT, and Flt-3 [214]. Thus, while initially considered a selective RAF kinase inhibitor, sorafenib is a multikinase inhibitor that targets several receptor tyrosine kinases such as human VEGF receptors (VEGF-R) 1 to 3, PDGF receptor, and RET [221, 222]. The results of a recent meta-analysis suggest that sorafenib has only a modest effect in patients with radioiodine-refractory differentiated thyroid cancer and shows also a high incidence of adverse effects that may affect the quality of patients’ life [223].
Show more

136 Read more

Expression of Immunohistochemical Markers (CD56 and P63) in Various Non-Neoplastic and Neoplastic Lesions of Thyroid Gland

Expression of Immunohistochemical Markers (CD56 and P63) in Various Non-Neoplastic and Neoplastic Lesions of Thyroid Gland

neoplasms was considerably more. Study population differences, effect of environment not only on gland but on the disease process and also on the technique of processing the tissue, might be the cause for this difference. Shin MK et al., also observed positive CD56 staining reaction in most of their non-neoplastic and benign neoplastic lesions, but was found to be negative in most of the PTC studied [12]. In spite of the fact that the present study had fewer neoplastic lesions compared to theirs’, the present findings correlated considerably with their study. Jeong JY et al., studied only follicular patterned lesion and observed an increased CD56 expression in non-neoplastic and benign neoplastic lesions while the expression was decreased in PTC and Follicular carcinoma [13]. Follicular carcinoma and Hurthle cell carcinoma were negative for CD56 in the present study also. Their study did not include thyroiditis, hence a comparative analysis in this category of lesions could not be done. Etem H et al., also studied only follicular neoplasms and PTC and found an absent CD56 staining in 35%
Show more

5 Read more

Non-neoplastic hepatopancreatobiliary lesions simulating malignancy: can we differentiate?

Non-neoplastic hepatopancreatobiliary lesions simulating malignancy: can we differentiate?

Several non-neoplastic abnormalities may simulate ma- lignant disease and differential diagnosis may be difficult by imaging alone. However, the imaging characteristics and enhancement pattern of the lesion with the assess- ment of vascular involvement may be very helpful. Co- involvement of the spleen should raise the possibility of an infectious or inflammatory process, as should discrete cystic foci in a solid lesion. Multimodality imaging in relevant cases may also be extremely useful by delineat- ing the different imaging aspects of the same lesion. Be- sides all these parameters, patient demographics, clinical symptoms, and signs such as fever, laboratory data, tumor markers, short-term changes of imaging findings, and imaging findings of diffusion-weighted imaging (DWI) should all be taken into account for correct diag- nosis. Close communication with the referring physician is another important point to be considered. It should be borne in mind that many unusual infectious and non- infectious inflammatory lesions may be sampled for diagnosis with imaging guidance and that this approach is safe in experienced hands and should be liberally used as a tool for early diagnosis.
Show more

19 Read more

Comparative Study of Hematoxylin & Eosin, Special Stains and Immunohistochemistry for Detection of Helicobacter Pylori in Both Neoplastic and Non-Neoplastic Gastric Lesions

Comparative Study of Hematoxylin & Eosin, Special Stains and Immunohistochemistry for Detection of Helicobacter Pylori in Both Neoplastic and Non-Neoplastic Gastric Lesions

DECLARATION I, Dr.L.R.UMASANKARI, solemnly declare that the dissertation titled “COMPARATIVE STUDY OF HEMATOXYLIN&EOSIN ,SPECIAL STAINS AND IMMUNOHISTOCHEMISTRY FOR DETECTION OF HELICOBACTER PYLORI IN BOTH NEOPLASTIC AND NON- NEOPLASTIC GASTRIC LESIONS” is the bonafide work done by me at Institute of Pathology, Madras Medical College under the expert guidance and supervision of Prof. Dr.S.PAPPATHI,M.D., Professor of Pathology, Institute of Child Health , Madras Medical College. The dissertation is submitted to the TamilnaduDr.M.G.R Medical University towards partial fulfilment of requirement for the award of M.D., Degree (Branch III) in Pathology.
Show more

162 Read more

Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix

Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix

A series of epigenetic alterations have been identified that occur during each of the stages of CC, both in the HPV and in the genome of the host cell [10]. One of the earliest pieces of evidence on record with respect to this subject was thanks to a [3 H]-S-adenosylmethionine incorporation assay performed on cervical neoplastic tis- sue. In this study, it was observed that the degree of hypomethylation (degree of incorporation of the [3 H]- methyl group) increased progressively together with the advance of the cervical neoplasia [22]. This finding was confirmed by later studies that involved quantitative analyses of DNA methylation supported by computer analysis on interphase nuclei by immune-labeling with anti-5-methylcytosine antibodies. A progressive demethylation of the tissue was observed in samples of dysplasia and cancer compared to normal controls [23,24].
Show more

7 Read more

Histomorphological analysis and clinical correlation of neoplastic and non neoplastic skin lesions: a study in a tertiary care centre of Western Uttar Pradesh, India

Histomorphological analysis and clinical correlation of neoplastic and non neoplastic skin lesions: a study in a tertiary care centre of Western Uttar Pradesh, India

Histopathological diagnosis was made by two independent pathologists was made and microscopic findings were correlated with the clinical diagnosis. Based on the histopathological diagnosis, the cases were divided into 15 broad groups, namely Genodermatoses, non-infectious erythematous, papular and squamous diseases, vascular diseases, vesicobullous and pustular diseases, connective tissue diseases, inflammatory diseases of adnexal structures, infectious diseases, tumors and cysts of skin, histiocytosis, pigmentary disorders, degenerative and perforating disorders(perforating folliculitis), non-infectious granuloma, inflammatory diseases of subcutaneous fat, pigmentary disorders. 1 A category of nonspecific dermatoses was given to the cases in which nonspecific histopathologic findings were reported. Other demographic data including age, sex along with site of lesion, type of lesion, duration of symptoms, provisional clinical diagnosis was recorded and analysed. The histopathological diagnosis given was matched with the single or multiple provisional clinical diagnoses made by the dermatologist and clinicopathologic consistency was evaluated. Cases were divided as being clinicopathologically consistent where the provisional diagnosis/diagnoses matched with the histopathologic diagnosis, clinicopathologically inconsistent where it did not match. Cases were labelled as partially consistent, where a specific variety of a dermatologic lesion was missed in the clinical diagnosis or authors found some another pathologic lesion in addition to the provisional clinical diagnosis. Statistical analysis was done using R studio.
Show more

8 Read more

The molecular pathology of neoplastic and non-neoplastic vulval disease

The molecular pathology of neoplastic and non-neoplastic vulval disease

1997), and in lung alveolar epithelial cells (Corroyer, 1997), dexamethasone inhibits proliferation but has no effect on the levels o f cyclin D l, D2 or D3 in cells in the mid­ log phase o f cell growth. Corticosteroids appear to have little effect on the levels o f cyclin D l in treated LS lesions. However, in histologically normal epidermis cyclin D l was found to be over expressed. It is presumed since these biopsies had been taken for clinical reasons, there could be molecular changes, and over expression o f cyclin D l could antedate any histological changes although it is interesting that topical corticosteroids had no effect on the level o f the protein. W hether this over expression is caused by gene amplification, mRNA over expression alone or protein over expression due to post transcriptional events (Hall & Peters, 1996) is currently unknown.
Show more

414 Read more

Show all 10000 documents...