Nuclear antigen lana
Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... latency-associated nuclear antigen (LANA) has been detected in almost all KSHV-infected cells by immunofluorescence and is character- ized by a punctate nuclear pattern (13, 24, 34, 41, ...
14
Tissue Specificity of the Kaposi's Sarcoma-Associated Herpesvirus Latent Nuclear Antigen (LANA/orf73) Promoter in Transgenic Mice
... latency-associated nuclear antigen LANA/orf73. LANA is required for latent episome maintenance and has also been implicated in ...of LANA expression is critical to KSHV ...the ...
9
Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs
... Latency-associated nuclear antigen (LANA) is a multifunctional protein en- coded by members of the Rhadinovirus genus of ...that LANA is important for acute replication, latency establishment, ...
13
Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression
... latency-associated nuclear antigen (LANA) during early infection. LANA, in turn, represses transcription and RTA function to establish and maintain KSHV ...between LANA and the ...
14
Kaposi's Sarcoma-Associated Herpesvirus Inhibits Interleukin-4-Mediated STAT6 Phosphorylation To Regulate Apoptosis and Maintain Latency
... latency-associated nuclear antigen (LANA) encoded by open reading frame 73 (ORF73) has been documented as one of the major latent proteins consistently present in all KSHV-asso- ciated tumors ...
11
Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats
... latency-associated nuclear antigen (LANA) encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV) plays a major role in maintaining latency and is critical for the perpetual segregation of viral ...
12
The Herpesvirus Saimiri Open Reading Frame 73 Gene Product Interacts with the Cellular Protein p32
... latency-associated nuclear antigen (LANA) is expressed during a latent infection and can modulate both viral and cellular gene ...to LANA; however, the role of HVS ORF 73 is ...distinct ...
11
Disruption of LANA in Rhesus Rhadinovirus Generates a Highly Lytic Recombinant Virus
... latency-associated nuclear antigen (LANA) protein of both KSHV and RRV plays key roles in the establishment and maintenance of these ...⌬ LANA/GFP) in which the RRV LANA open reading ...
17
Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation
... latency-associated nuclear antigen (LANA), a multifunctional protein of Kaposi’s sarcoma-associated herpesvirus (KSHV) that is found in Kaposi’s sarcoma tumors, upregulates survivin expression and ...
13
The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency
... Latency-associated nuclear antigen (LANA), the pri- mary viral product during latency, has been reported to bind to a series of cellular gene promoters to modulate gene ...by LANA, we ...
17
Acetylation of the Latency-Associated Nuclear Antigen Regulates Repression of Kaposi's Sarcoma-Associated Herpesvirus Lytic Transcription
... latency-associated nuclear antigen (LANA) during latency. Depletion of LANA by small interfering RNA derepressed ORF50 transcription in the latently infected BCBL1 pleural effusion lymphoma- ...
10
Induction of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen by the Lytic Transactivator RTA: a Novel Mechanism for Establishment of Latency
... latency-associated nuclear antigen (LANA) encoded by open reading frame 73 (ORF73), viral cyclin (v-cyclin) encoded by ORF72, viral Fas-associated death domain interleukin 1L-converting enzyme ...
13
Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency
... K aposi’s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8, belongs to the subfamily Gammaher- pesviridae. It is the most recently identified oncogenic DNA her- pesvirus. KSHV is related to Kaposi’s ...
14
Involvement of SSRP1 in Latent Replication of Kaposi's Sarcoma-Associated Herpesvirus
... latency-associated nuclear antigen (LANA), which functions as an origin binding protein, and the latent origin, which resides within the terminal repeats (TRs) of the viral ...two LANA binding ...
13
Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... latency-associated nuclear antigen (LANA), the product of ...of LANA reveals some structural features reminiscent of transcription factors, leading us to hypothesize that LANA may ...
11
Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... latency-associated nuclear antigen (LANA) is en- coded by open reading frame 73 (ORF 73) of the viral ...cycle. LANA is required for replication and maintenance of the viral DNA during latent ...
11
A Role for the Internal Repeat of the Kaposi's Sarcoma-Associated Herpesvirus Latent Nuclear Antigen in the Persistence of an Episomal Viral Genome
... latent nuclear antigen (LANA), vCYC, vFLIP, kaposin/K12, a cluster of microRNAs (miRNAs), and in B cells additionally, ...16–18). LANA is essential for KSHV ...domains, LANA has an ...
5
Characterization of the Minimal Replicator of Kaposi's Sarcoma-Associated Herpesvirus Latent Origin
... latency-associated nuclear antigen (LANA), is expressed and the viral genome is maintained as multiple copies of episomal DNA (10, 11, 28, ...32). LANA is a functional homologue of origin ...
6
CELL PROLIFERATION AND VOLUME-WEIGHTED MEAN NUCLEAR VOLUME IN HIGH-GRADE PIN AND ADENOCARCINOMA, COMPARED WITH NORMAL PROSTATE
... the nuclear size and its variability in the preneoplastic epithelium of PIN, although some authors have suggested that the cytologic atypia and nuclear pleomorphism were more remarkable in the basal layer ...
7
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency-Associated Nuclear Antigen Regulates the KSHV Epigenome by Association with the Histone Demethylase KDM3A
... HeLa nuclear extracts. 3 ⫻ Flag-tagged LANA was stably expressed in HeLa cells, and nuclear extracts were prepared from 8 liters of suspension ...heterogeneous nuclear ribonucleoprotein K. (B) ...
12