Nuclear bodies
PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals
... Promyelocytic leukemia protein (PML) is part of a large multiprotein nuclear complex known as promyelocytic leukemia nuclear bodies (PML-NBs), which is associated with the nuclear matrix [1]. ...
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Emerging Role of PML Nuclear Bodies in Innate Immune Signaling
... PML nuclear bodies (PML-NBs) or nuclear domains 10 ...be nuclear protein depots, sites of nuclear activities ...into nuclear track-like structures by adeno- viruses or a ...
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The herpes simplex virus 1 UL11 proteins are associated with cytoplasmic and nuclear membranes and with nuclear bodies of infected cells.
... nuclear bodies of type V morphotype in that they appear uniform in density and consist of a microfibrillar-like ...dense bodies differing in morphology as observed by conventional electron micro- ...
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Nuclear protein IK undergoes dynamic subcellular translocation and forms unique nuclear bodies during the cell cycle
... round nuclear bodies of difference sizes and the number of nuclear bodies varied from 2–30 per cell (Figure 2A, lower ...IK nuclear bodies, HeLa cells were transfected with the ...
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Assembly of Epstein-Barr Virus Capsid in Promyelocytic Leukemia Nuclear Bodies
... The Epstein-Barr virus (EBV) capsid contains a major capsid protein, VCA; two minor capsid proteins, BDLF1 and BORF1; and a small capsid protein, BFRF3. During the lytic cycle, these capsid proteins are synthesized and ...
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Epstein-Barr Virus Nuclear Antigen 1 Hijacks the Host Kinase CK2 To Disrupt PML Nuclear Bodies
... (PML) nuclear bodies (NBs) by inducing the degradation of PML proteins, leading to impaired DNA repair and increased cell ...PML bodies and degrade PML ...
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The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells
... in nuclear foci of Bay 38-7690-treated infected cells in a time- and dose-dependent ...(PML) nuclear bodies (NBs), which are structures that affect many cellular functions, including DNA damage ...
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The Alphaherpesvirus Serine/Threonine Kinase Us3 Disrupts Promyelocytic Leukemia Protein Nuclear Bodies
... facilitating nuclear egress of capsids, stimulating mRNA trans- lation and promoting cell-to-cell spread of virus ...protein nuclear bodies ...
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Role of ND10 nuclear bodies in the chromatin repression of HSV 1
... defense, nuclear substructure restriction and epigenetic chromatin regulation, have been intensively studied in the recent ...discrete nuclear bodies termed nuclear domain 10 (ND10), converge ...
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Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies
... The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These cellular activities ...
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Functional Reorganization of Promyelocytic Leukemia Nuclear Bodies during BK Virus Infection
... many nuclear components, and subnuclear structures such as promyelocytic leukemia nuclear bodies (PML-NBs) are known to play regulatory roles during a number of DNA virus ...
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Identification of repressive and active epigenetic marks and nuclear bodies in Entamoeba histolytica
... while the second is located between amino acids 10 and 11, and the third is located after amino acid 14 [5]. This last insertion site merits particular attention due to the presence of three extra lysine residues, which ...
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An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies
... nuclear import of Ad genome complexes, it can be used as a marker depicting the localization of viral genome complexes in living cells (29). U2OS cells stably expressing EGFP-TAF-I  (U2OS/EGFP-TAF-I cells) were ...
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Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
... discrete nuclear speckles reminiscent of the punctate pattern shown by full-length LANA (7, 16, 19, ...simple nuclear localization sequences (9, 25), and similar sequences occur in the N termini of all the ...
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Components of Promyelocytic Leukemia Nuclear Bodies (ND10) Act Cooperatively To Repress Herpesvirus Infection
... Components of the SUMO and DNA repair pathways are re- cruited to parental HSV-1 genomes in the absence of hDaxx, PML, and Sp100. One hallmark of intrinsic resistance to HSV-1 is the recruitment of restrictive factors, ...
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H-1 Parvovirus-Associated Replication Bodies: a Distinct Virus-Induced Nuclear Structure
... a nuclear structure that is induced after infection with the autonomous parvovirus ...distinct nuclear bodies which we designated H-1 parvovirus-associated replication bodies (H-1 ...cell ...
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Implication of the Lymphocyte-Specific Nuclear Body Protein Sp140 in an Innate Response to Human Immunodeficiency Virus Type 1
... in nuclear-matrix-associated nuclear bodies (NBs), also called PML oncogenic domains or nuclear domains 10 (6, 11, 12, 16, 18, 20, 34, 48, 49, 54, ...
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Phosphorylation of the Human T-Cell Leukemia Virus Type 1 Transactivator Tax on Adjacent Serine Residues Is Critical for Tax Activation
... discrete nuclear bodies both in HTLV-1-trans- formed lymphocytes and in cells infected with an SFV-Tax ...these nuclear structures with cellular factors essential for its transcriptional activities, ...
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Identification of a Domain in Human Immunodeficiency Virus Type 1 Rev That Is Required for Functional Activity and Modulates Association with Subnuclear Compartments Containing Splicing Factor SC35
... shaped nuclear bodies instead of in interchromatin gran- ules and perichromatin ...staining nuclear struc- tures corresponded exactly to the bodies containing Rev⌬Loop ...SC35-positive ...
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The Epstein-Barr virus-encoded nuclear antigen EBNA-5 accumulates in PML-containing bodies.
... (EBV)-encoded nuclear proteins required for immortalization of human B ...with nuclear bodies positive for PML, the promyelocytic leukemia-associated ...the bodies consist of at least two ...
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