nuclear factor-kappaB
Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes
... Necrosis Factor-alpha (TNF-α) ...growth/scatter factor and prostaglandin E 2 (PGE 2 ) ...the Nuclear Factor-kappaB (NF- κB) signal transduction pathway ...tion factor that is ...
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Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice
... With regard to TNF-α production, our results showed higher expression in NF-κB decoy ODNs-treated smoke induced mice compared with NS or Scr-treated control mice. The possible explanations for this result may be the ...
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Bruton's tyrosine kinase is a Toll/interleukin 1 receptor domain binding protein that participates in nuclear factor kappaB activation by Toll like receptor 4
... survival. It has also been shown to be important for IgE- mediated activation of mast cells resulting in allergic reactions. Btk kinase activity and tyrosine phosphorylation have both been shown to increase upon ...
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Constitutive nuclear factor kappaB RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
... An antiapoptotic function of RelA in H/RS cells. The HD cells were protected by constitutive NF-kB against growth fac- tor withdrawal–induced apoptosis, similar to the protective ef- fect of transiently induced NF- kB in ...
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CENTRAL NERVOUS EFFECTS OF C TYPE NATRIURETIC PEPTIDE AND NUCLEAR FACTOR KAPPAB; IMPLICATIONS IN CARDIOVASCULAR STRESS
... 39. Kaltschmidt B, Ndiaye D, Korte M, Pothion S, Arbibe L, Prüllage M, Pfeiffer J, Lindecke A, Staiger V, Israël A, Kaltschmidt C, Mémet S.NF-kappaB regulates spatial memory formation and synaptic plasticity ...
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Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models
... The generation of Ab requires the proteolytic cleavage of APP by an aspartyl protease named BACE1 [86]. A number of transcriptional factors as well as post- transcriptional modifications and intracellular signaling ...
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The roles of the classical and alternative nuclear factor kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
... B, nuclear factor- κ B; RIP, receptor interacting protein; TAB, TAK1-binding protein; TAK, transforming growth factor β - activated kinase; TRAF, TNF receptor-associated ...
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Oxidized low density lipoprotein inhibits lipopolysaccharide induced binding of nuclear factor kappaB to DNA and the subsequent expression of tumor necrosis factor alpha and interleukin 1beta in macrophages
... A large body of evidence suggests that oxidized LDL (ox- LDL) has a role in atherogenesis. One effect is the impact on macrophage function. We have studied the effects of oxLDL and oxysterols on the binding of the ...
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Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor kappaB regulation and cytokine expression
... sponse element binding protein (CREB) in pulmonary mono- nuclear cell populations. Because binding sites for NF- k B and CREB are present in the promoter regions of cytokine genes, such as IL-1 b , TNF- a , and ...
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Moringa Oleifera aqueous leaf extract down regulates nuclear factor kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells
... outcome. Nuclear factor kappa B (NF-kB), a pro-inflammatory transcription factor, reportedly plays a significant role in the resistance of pancreatic cancer cells to apoptosis-based ...
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<p>Evaluation of plasma antimicrobial peptide LL-37 and nuclear factor-kappaB levels in stable chronic obstructive pulmonary disease</p>
... Antimicrobial peptide LL-37 circulating levels in chronic obstructive pulmonary disease patients with high risk of frequent exacerbations. Persson LJ, Aanerud M, Hardie JA, et al[r] ...
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Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells.
... 322 323 RelA-Enriched Regions Encoding or Juxtaposed to Genes Associated with Parturition 324 Enrichment of chromatin from TNF-treated cells by anti-RelA serum was seen to contain or be [r] ...
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Computational analysis of dynamics within the Nuclear Factor-kappaB signalling system
... Treatment with diclofenac appears to be a novel means to alter the NF-κB response to TNFα stimulation. Use of the compound showed a significant increase in the period of oscillations (figure 6.2) and there was an ...
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Rac1 regulates interleukin 1 induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha independent manner by enhancing the ability of the p65 subunit to transactivate gene expression
... cial mediator of both inflammatory and immune responses. The involvement of IL1 in the pathogenesis of inflammatory dis- eases such as rheumatoid arthritis has led to intensive studies on how IL1 signals are transduced ...
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Aberrant nuclear factor kappaB/Rel expression and the pathogenesis of breast cancer
... with nuclear extracts from either trans- formed cell line abrogated formation of the upper complexes and significantly reduced the level of the more rapidly migrat- ing complex (insets, ...scription factor ...
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Rinkenbaugh_unc_0153D_16413.pdf
... Crawford, H.C., Scoggins, C.R., Washington, M.K., Matrisian, L.M., and Leach, S.D. (2002). Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine ...
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Epigenetics in the pathogenesis of rheumatoid arthritis
... transcription factor nuclear factor-kappaB (NF-κB) to the promoter of cytokine genes [21], resulting in a cytokine-driven pro-inflammatory re- ...necrosis factor therapy are frequently ...
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Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model
... of nuclear factor-kappaB ligand; OPG: Osteoprotegerin; TSBY: Trypticase Soy Broth supplemented with yeast extract; BAP: Blood agar plates; PBS: Phosphate buffered saline; OD: Optical density; RT: ...
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Sneaking ligands inhibiting NF-kappaB activation selectively in endothelial cells improve experimental arthritides
... classical nuclear factor kappaB (NF-kappaB) pathway is related to the pathogenesis of several inflammatory autoimmune diseases including rheumatoid arthritis ...
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ORAL LICHEN PLANUS: THREE CASE REPORTS IN CHILDREN
... mediator nuclear factor kappaB (NFkβ), [21] and the inhibition of the transforming growth factor(TGF), control signaling pathway which may result in the hyper- proliferation of keratinocytes, ...
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