Nuclear factor κb
Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis
... The nuclear factor κB (NF-κB) family of Rel-related transcription factors, existing in almost all cells, is widely involved in functions such as immunity, inflammation, and stress ...
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Activation of macrophage nuclear factor-κB and induction of inducible nitric oxide synthase by LPS
... Background: Chronic lung disease (CLD) of prematurity is a major problem of neonatal care. Bacterial infection and inflammatory response have been thought to play an important role in the development of CLD and steroids ...
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Regulation of Sox9 activity by crosstalk with nuclear factor κB and retinoic acid receptors
... Effects of TNF-α and atRA on Sox9 activity. Chondrocytes were trans- fected with (a) the type II collagen enhancer luciferase reporter and some cultures were also co-transfected with (b) a phosphorylation site- deficient ...
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Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor κB family genes and their clinical relevance in patients with major trauma
... Genetic variation data for the entire NFKB1, NFKB2, RELA, RELB and REL genes and their surrounding selected regions were obtained from the HapMap project [15] (www.hapmap.org) for 137 Han Chinese individuals from Beijing ...
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Anti inflammatory effect of Prunus yedoensis through inhibition of nuclear factor κB in macrophages
... NF-κB is composed mainly of 2 proteins, p50 and p65 [28]. In stimulated cells, NF-κB is present in the cytoplasm and is bound to the inhibitory protein I-κB. Exposure of cells to various NF-κB ...
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RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb
... A previous study showed that RASSF8 was related to NF-κB pathway and may be required to maintain actin cytoskeletal organization [16]. Based on this study, P65 is lost from sites of cell–cell contact and gets ...
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Dermatan sulfate activates nuclear factor κb and induces endothelial and circulating intercellular adhesion molecule 1
... The finding that intraperitoneal administration of DS augmented circulating sICAM-1 demonstrated that this GAG can function in vivo and confirmed our in vitro data that DS induces ICAM-1. Mice administered other GAGs ...
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Ymer Acts as a Multifunctional Regulator in Nuclear Factor-κB and Fas Signaling Pathways
... Inflammations Induced in lpr/lpr Mice We showed that Ymer inhibits inflam- matory signaling including NF-κB with several stimulations. It is well known that lpr/lpr mice that lack Fas expression ex- hibit systemic ...
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Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression.pdf
... Interestingly, NF-kB directly regulates a potent antiapoptotic pathway. Genes regulated by NF-kB that suppress apoptosis, such as Bcl-2 and Bcl-xL (see Figure 1), are often expressed in human cancers. Given the strong ...
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... and nuclear factor-κB (NF-κB) on the cell viability, apoptosis, levels of pro-inflammatory cytokines, apoptosis-related molecules, and enzymes of the Krebs ...corticosterone; nuclear ...
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Multiple myeloma/hypercalcemia
... of nuclear factor-κB ligand [RANKL], macrophage inflammatory protein [MIP]-1 α , and tumor necrosis factors [TNFs]; see below) or over-expressed by other cells in the local microenvironment ...
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TNF Super Family Members OPG, RANKL, RANK and Osteoporosis: a link
... of nuclear factor κB ligand), a TNF family member that is essential for osteoclast formation, activity, and survival in normal and pathological states of bone ...
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Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
... Although the molecular mechanism or mechanisms responsible for the transcriptional changes observed are not completely understood, the increases in TF, PAI-1, and uPA are probably due to the production of proinflammatory ...
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Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... [11] Weichert W, Boehm M, Gekeler V, Bahra M, Langrehr J, Neuhaus P, Denkert C, Imre G, Weller C, Hofmann H, Niesporek S, Jacob J, Di- etel M, Scheidereit C, Kristiansen G. High ex- pression of RelA/p65 is associated ...
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... A nuclear factor-κB (NF-κB)-dependent inflammatory pathway, which produces inflammatory cytokines, and hypoxia-in- ducible factor-1 (HIF-1)-dependent adaptive pathway ...
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Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications
... growth factor 2; HNF1A: Hepatocyte nuclear factor 1A; HNSCC: Head and neck squamos cell carcinoma; HOX10A: Homeobox- leucine zipper 10 A protein; IC: Intracellular; ICD: Intracellular domain; IGF-1: ...
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Original Article Effect of acupuncture on expression levels of NF-κB, IL-1β, IL-6, and TNF-α in rats with cerebral ischemia and reperfusion
... of nuclear factor-κB (NF-κB), interleukin -1β (IL-1β), interleukin -6 (IL-6), and tumor necrosis factor-α (TNF-α) in rats with cerebral ischemia and ...
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Original Article Importin 8 is involved in human periodontitis by the NF-κB pathway
... Proteins were separated and then transferred onto membranes (Millipore, USA) as previously described [6]. The membranes were incubated with IPO8 antibody (1:500) and NF-κB pp65 (1:1000). After rinsing the ...
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Original Article EGCG suppresses NF- B activation induced by gastroesophageal reflux contents in human esophageal epithelial cells
... the nuclear factor kappa-light-chain- enhancer of activated B cells (NF-κB) signaling pathway in normal human esophageal epithelial cells (HEECs) and the effect of EGCG pretreatment of cells on ...
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Tumor metastasis to bone
... Establishment of skeletal metastasis involves bidirectional inter- actions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the patho- physiology of bone metastasis ...
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