nuclear pore complex
Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells
... two nuclear pore complex (NPC) proteins, Nup153 and ...125-MDa complex composed of multiple copies of 30 different ...of nuclear import and relocalization of host nuclear ...
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Elucidating the Mechanism of mRNA Export Regulation by the Nuclear Pore Complex
... the nuclear envelope, separating genetic information contained in the nucleus from the greater cell ...The nuclear pore complex (NPC) is nature’s largest protein channel, and it is the sole ...
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Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore Complex Biogenesis
... when nuclear pore complexes (NPCs) are constructed within the existing nuclear membrane, as occurs during in- terphase in all ...essential nuclear envelope/endoplasmic reticulum (NE/ER) ...
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Super-resolution imaging visualizes the eightfold symmetry of gp210 proteins around the nuclear pore complex and resolves the central channel with nanometer resolution
... most complex molecular machines of cells is the nuclear pore complex (NPC), which controls all trafficking of molecules in and out of the ...oocyte nuclear envelopes, with a lateral ...
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Single molecule imaging to characterise the transport mechanism of the Nuclear Pore Complex
... In the eukaryotic cell, a large macromolecular channel, known as the Nuclear Pore Complex (NPC), mediates all molecular transport between the nucleus and cytoplasm. In recent years, single-molecule ...
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Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome
... In summary, we here discovered recessive mutations in the genes NUP85, NUP133, and NUP160 as 3 monogenic causes of SRNS. Interestingly, all 3 genes and the gene NUP107, in which we found 3 pathogenic alleles, encode ...
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Mengovirus-Induced Rearrangement of the Nuclear Pore Complex: Hijacking Cellular Phosphorylation Machinery
... the nuclear pores appears to be primarily due to proteolytic degradation of some nucleoporins (protein components of the pore), whereas this effect in cardiovirus-infected cells is triggered by the leader ...
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Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... The accessory gene vpr is present in all viruses that belong to the five phylogenetic lineages of primate lentiviruses. The hu- man immunodeficiency virus type 1 (HIV-1) Vpr protein is well conserved in terms of primary ...
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Selective Removal of FG Repeat Domains from the Nuclear Pore Complex by Enterovirus 2Apro
... receptor-cargo complex across the nuclear envelope (reviewed in reference ...on nuclear transport and NPC function, with some pathways exhibiting greater sensitivity to the loss of one Nup over ...
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Nucleoporin FG Domains Facilitate mRNP Remodeling at the Cytoplasmic Face of the Nuclear Pore Complex
... ABSTRACT Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 ...
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The nuclear pore complex
... isolated nuclear envelopes to remove this contaminating material also remove pore complex proteins, making the purification diffi- ...of pore complexes that are found in differentiating and ...
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Importin β modulates the permeability of the nuclear pore complex in a Ran dependent manner
... the nuclear face of the NPC, in addition to displacing impβ from cargos (Gorlich et ...the pore but had an ∼100-fold higher probability of exiting the pore at the cytoplasmic face than the ...
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Nuclear Pore Complex Function in Saccharomyces cerevisiae Is Influenced by Glycosylation of the Transmembrane Nucleoporin Pom152p
... Decreased glycosylation suppresses nup1D temper- ature sensitivity: Alg12p is a mannosyltransferase required for normal assembly of lipid-associated polysaccharide chains in the ER. Once assembled, these branched chains ...
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Venezuelan Equine Encephalitis Virus Capsid Protein Forms a Tetrameric Complex with CRM1 and Importin α/β That Obstructs Nuclear Pore Complex Function
... the nuclear/cytoplasmic distribution of 4 ⫻ Tomato-3 ⫻ NLS when expressed alone and the dis- tribution of the same protein when coexpressed with mutant peptide- ...in nuclear-reporter accumulation was ...
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Importin-α Promotes Passage through the Nuclear Pore Complex of Human Immunodeficiency Virus Type 1 Vpr
... the nuclear localiza- tion of PIC, is a small (14-kDa) nuclear protein of 96 amino acids that plays various roles in viral infection and cellular functions (6, ...the nuclear envelope (29, 54), but ...
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BGLF4 Kinase Modulates the Structure and Transport Preference of the Nuclear Pore Complex To Facilitate Nuclear Import of Epstein-Barr Virus Lytic Proteins
... and nuclear envelope-associated proteins in cells replicating EBV, slide-cultured NA cells were transfected with an Rta-expressing plasmid to induce virus rep- ...the nuclear trans- port of viral proteins, ...
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Differential Processing of Nuclear Pore Complex Proteins by Rhinovirus 2A Proteases from Different Species and Serotypes
... 218, 247, and 298. The Cw12 and Cw24 enzymes cleaved some of these sites (103 and 247[?]), but not others, and there were individual differences between these proteases in the rates and final profile patterns. Neither of ...
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Ran GTPase Regulates Mad2 Localization to the Nuclear Pore Complex
... of nuclear-cytoplasmic trafficking ...proper nuclear-cytoplasmic com- partmentalization of the yeast Ran homologue, ...classical nuclear localization signal (NLS) or nuclear export signal ...
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Herpesvirus Capsid Association with the Nuclear Pore Complex and Viral DNA Release Involve the Nucleoporin CAN/Nup214 and the Capsid Protein pUL25
... itory effect on the number of incoming capsids associating with the nucleus, and a similar effect was observed when Nup358/ RanBP2 levels were reduced by RNA silencing. Nup358/ RanBP2 is a large nucleoporin that is a ...
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Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
... lar chromatin in various transcriptional states, resulting in different integration patterns, as previously observed for HIV-1 and MLV (63). Although the chromatin topology is likely to play a role in retroviral ...
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