NUCLEAR TRANSPORT
Baculovirus Infection of Nondividing Mammalian Cells: Mechanisms of Entry and Nuclear Transport of Capsids
... to transport its genome across the nuclear membrane of mammalian ...cytoplasmic transport of the ...at nuclear pores of nondividing ...the nuclear pore. This mode of transport ...
10
Viral Oncolysis That Targets Raf-1 Signaling Control of Nuclear Transport
... Trimers of MVM capsid subunits assembled in insect cells are not competent for nuclear transport. In mammalian cells susceptible to the parvovirus MVM, the capsid proteins (VPs) accumulate intranuclear (12, ...
10
Classic Nuclear Localization Signals and a Novel Nuclear Localization Motif Are Required for Nuclear Transport of Porcine Parvovirus Capsid Proteins
... tion for mutants IC-R374G, IC-R393G, IC-R565G, and IC- K487G. Fitness experiments were performed with replicative infectious clones as explained for VP1up mutants. Figure 7B to D show that both mutant K272G and R477G ...
12
The directionality of the nuclear transport of the influenza A genome is driven by selective exposure of nuclear localization sequences on nucleoprotein
... that nuclear-exported NP contains a masked NLS1, thereby preventing this mole- cule from re-entering the ...of nuclear trafficking of vRNPs during the influenza A viral life ...are nuclear exported, ...
12
Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport.
... direct nuclear import, confirming that this sequence con- tained a bona fide ...Xenopus nuclear protein N1 has a bipartite NLS with an ami- no-terminal basic sequence (RKKKRK) which resembles both the SV40 ...
8
Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins.
... on nuclear import of free ...the nuclear transport of free NP, the most abundant structural protein of the vRNP complex, since recent reports have impli- cated NP in targeting the vRNP into the ...
11
Protein Arginine Methylation in Candida albicans: Role in Nuclear Transport
... Methylation of ScNpl3 disrupts protein-protein interactions, including Npl3 self-association (49). The RGG domain helps direct ScNpl3 self-association, since PrA-ScNpl3 can interact with the RGG domain alone in hmt1 ⌬ ...
11
Functional interaction of nuclear transport-defective simian virus 40 large T antigen with chromatin and nuclear matrix.
... Leakiness of the Lys-128 mutation for nuclear transport first was supported by our finding that Lys-128-mutant large T accumulated at nuclear substructures during the course of infection[r] ...
9
Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation.
... We have examined the nuclear transport of the protein products of our v-myb deletion and truncation mutants and identified two indepen dent in nuclear accumulation of p48vmyb Mutants and[r] ...
8
Review Article Nuclear transport oxidative stress and neurodegeneration
... of nuclear transport in re- sponse to oxidative stressors in various models ...of nuclear transport of signaling proteins on the regulation of gene expression, alterations in this process can ...
15
The VP1 N-Terminal Sequence of Canine Parvovirus Affects Nuclear Transport of Capsids and Efficient Cell Infection
... the nuclear pore in a slow process that appears to require confor- mational changes of the capsids (28, 30, ...the nuclear pore, where they release their DNA genomes and viral proteins that mediate ...
8
Cytoplasmic Trafficking of the Canine Parvovirus Capsid and Its Role in Infection and Nuclear Transport
... microtubule-dependent transport steps are also required ...and nuclear tar- geting of the virus or its genome prior to replication are still poorly ...and nuclear replication of the ...
7
Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22
... β-dependent nuclear import/ export pathways [39], the NLSs of which could be directly recognized by several importin β members, especially the extensively studied importin β1 and importin β2 (transportin-1) ...
10
Importin beta like nuclear transport receptors
... factors Yap1p [56], and Ace2p [57], the mitogen-activated protein kinase Hog1p [58], and the heat-shock protein Ssb1p [59]. CAS (yeast Cse1p) functions in the export and recycling of importin a [60-63]. Msn5p was first ...
9
In vitro model for the nuclear transport of the hepadnavirus genome.
... the transport, leading to a release of the polymerase-DNA ...the nuclear import of the viral ...the nuclear import of the WHV genome or whether the presence of the entire nucleocapsid is a ...
7
Identification of Domains in Autographa californica Multiple Nucleopolyhedrovirus Late Expression Factor 3 Required for Nuclear Transport of P143
... a nuclear localization signal domain, we constructed a series of LEF-3 deletion mutants and examined the intracellular localization of the products in plasmid-transfected ...for nuclear localization and ...
8
Synthesis, posttranslational modifications, and nuclear transport of polyomavirus major capsid protein VP1.
... A time course experiment in which infected MKC were fractionated into cytoplasmic and nuclear fractions at various intervals after the addition of cycloheximide revealed the effect of pr[r] ...
8
Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals.
... small nuclear RNAs (45), the proteins, or a combination of ...the nuclear membrane in a nucleus-to- cytoplasm direction; examples include nucleolin (6, 95), the heterogeneous nuclear RNP particle A1 ...
10
The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport.
... In order to investigate whether this sequence contains an unusual nuclear localization signal, a protein named lOG was created by fusing the proximal precore sequence to the amino termin[r] ...
7
Isolation and characterization of a viable adenovirus mutant defective in nuclear transport of the DNA-binding protein.
... Partial block to transcription of human adenovirus type 2 late genes in abortively infected monkey cells.. A short amino acid sequence able to specify nuclear location.[r] ...
11