Nucleic acids
Nucleic Acids and Proteins
... The nucleic acids DNA and RNA have many chemical and structural similarities but can function differently based on the nucleotide monomers from which they are ...
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Therapeutic Opportunities and Approaches to Sequence Control for Nucleic Acids
... Nucleic acids play essential roles in ...for nucleic acids to play these roles is a function of their ...Locked Nucleic Acid (LNA), 2’ O- methyl, and ...
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Analysis of interacting nucleic acids in dilute solutions
... Motivated by the growing demand for analysis tools for diverse natural and engineered DNA and RNA sys- tems, we develop a general theory and set of computational algorithms to perform thermodynamic analysis of dilute ...
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Rapid and simple method for purification of nucleic acids
... By using size-fractionated silica particles, nucleic acids covalently closed circular, relaxed circular, and linear double-stranded DNA; single-stranded DNA; and rRNA could be purified f[r] ...
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In situ hybridisation for the detection of viral nucleic acids
... It is In the study of chronic diseases of viral aetiology that in situ hybridisation has become a technique of major Importance. A frequent theme in the establishment of persistent infections is a reduction in the levels ...
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Purification of Nucleic Acids by Hybridization to Affinity Tagged PNA Probes
... Part of the reason for this is that the use of DNA capture probes faces a number of practical problems. One of these are the need for high affinity capture probes that provide a probe/target stability that will survive ...
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UVC photon flux, the nucleic acids. Oligos of
... the nucleic acids. Oligos of nucleic acids with affinity to particular amino acids which foment UVC photon dissipation would have been selected through non-equilibrium thermodynamic ...
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Circulating nucleic acids as biomarkers in breast cancer
... As circulating cell-free tumor nucleic acids may reflect the characteristics of the primary tumor and even of micrometastatic cells, they may be excellent blood biomarkers for screening [r] ...
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Circulating nucleic acids in plasma and serum (CNAPS): applications in oncology
... The data reviewed in the present article suggest that the clinical value of cfNAs circulating in plasma is already more than a theoretical idea, since the characterization and the quantitation of such nucleic ...
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Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers
... Extracellular nucleic acids (NAs), both DNA and mRNA, have been found to exist in many biological media, including serum, plasma, saliva, urine, semen, milk and bronchial lavage, as well as cell culture ...
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Evolution of Cyclic Peptide Scaffolds to Target Nucleic Acids
... of nucleic acid’s role in cellular processes, it has become abundantly clear that DNA and RNA can provide a great tool and target for drug ...of nucleic acid’s role in life processes is expanding, the area ...
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Comparison of the nucleic acids of helical and coccoid forms of Helicobacter pylori.
... Bacterial nucleic acids are usually extracted with guanidium thiocyanate (35), which we also used in the present ...decreased nucleic acid content was associated with the loss of cytoplasm by ...
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An improved procedure for the synthesis of vinylphosphonate-linked nucleic acids
... limitations, naturally occurring phosphodiester-linked nucleic acids (DNA and RNA 1, Fig. 1) are not suitable drug candidate molecules. One of their main limitations is their instability towards a number of ...
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In-silico design of computational nucleic acids for molecular information processing
... years nucleic acids have become a focus of interest for prototype implementations of molecular computing ...ribonucleic acids as components of the regulatory networks within living cells has ...
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Synthesis and Characterization of Peptide Nucleic Acids Incorporating Modified Nucleobases
... Peptide Nucleic Acid (PNA), is a mimic of natural nucleic acids, also known as the building blocks of DNA, with exceptional binding ...modified nucleic acids, and PNA oligomerization ...
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Circulating nucleic acids as a new diagnostic tool
... cell-free nucleic acids is paradoxically decreased in 90% of ...of nucleic acids in the plasma is the active release of these nucleic acids into circulation ...
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The Synthesis and Characterization of Glycol Nucleic Acids
... new nucleic acid analog with self-pairing ability usually comes interest as to how this new analog interacts with DNA and ...the nucleic acid analog as a molecule to interfere with gene expression inside ...
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NUCLEIC ACIDS Centrifugation pdf
... which the genetic material (nucleic acids) represents a minor component. The investigator is therefore faced with the daunting task of separating proteins, lipids, and nucleic acids from each ...
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Bridged Nucleic Acids Reloaded
... progress in nucleic acids research, led to the design of nucleotide analogs that when.. 26.[r] ...
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MEDICINAL CHEMISTRY OF NUCLEIC ACIDS
... The structural integrity of DNA is essential to enable its role as the reposi- tory of genetic information. Agents that alter DNA structure are mutagenic and potentially carcinogenic. Accordingly, organisms have evolved ...
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