Nucleoside Analogs
3′-Azido-3′-Deoxythymidine (AZT) Mediates Cross-Resistance to Nucleoside Analogs in the Case of AZT-Resistant Human Immunodeficiency Virus Type 1 Variants
... Difficulties in deciphering the mechanisms of 3 * -azido-3 * -deoxythymidine (AZT)-resistance by human im- munodeficiency virus type 1 (HIV-1) variants are due in part to an inability to reconstitute resistance in vitro ...
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Diverse models for anti-HIV activity of purine nucleoside analogs
... Diverse techniques such as DT, RF, SVM, and MAA were successfully used to develop models for anti-HIV purine nucleoside analogs. Models based on DT, RF, and SVM statistical approaches show an accuracy of ...
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<p>Assessment of microRNA expression in leukemic cells as predictors of sensitivity to purine nucleoside analogs, fludarabine and cladribine, in chronic lymphocytic leukemia patients</p>
... Background: Great progress has been achieved lately in the therapy for chronic lympho- cytic leukemia (CLL), one of the most frequently diagnosed adult leukemias. New classes of drugs, such as kinase inhibitors and BCL-2 ...
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Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin A new strategy for cancer chemotherapy
... antineoplastic activity depends on their conversion to tiazofurin-adenine dinucleotide and selenazofurin-adenine dinucleotide which are analogs of NAD. The present study was conducted to determine whether these ...
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The Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation I132M Confers Hypersensitivity to Nucleoside Analogs
... The I132M mutation in HIV-1 RT was identified in a phe- notypic screen of clinical HIV-1 isolates from patients for whom therapy containing an NNRTI was failing (6, 16), and we previously demonstrated that this mutation ...
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Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells
... In the last experiment comparing tested NAs, we analyzed their synergy with SCH900776 in 17 B-cell lines. We observed that (i) GEM was superior in terms of sensitized cell lines number confirming its position of optimal ...
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Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
... N onnucleoside reverse transcriptase inhibitors (NNRTIs), which target the essential viral enzyme reverse transcriptase (RT), have been an integral part of human immunodeficiency virus type 1 (HIV-1) therapy since they ...
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A Mammalian-Like DNA Damage Response of Fission Yeast to Nucleoside Analogs
... of nucleoside analogs such as BrdU, FdU, and IdU (Sivakumar et ...BrdU analogs show toxicity at much lower doses and may activate a Rad3 (ATR/Mec1)-dependent damage response pathway (Hodson et ...
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Effective Lethal Mutagenesis of Influenza Virus by Three Nucleoside Analogs
... of nucleoside analog ...three nucleoside analogs, there is a narrow window between the con- centrations that allow for persistence and those that quickly cause ...
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Synergistic antitumor effect of adenovirus armed with <em>Drosophila melanogaster</em> deoxyribonucleoside kinase and nucleoside analogs for human breast carcinoma in vitro and in vivo
... tion and then infected with pZD55–dNK, pZD55, DL1520, or WtAd (MOI = 1). Virus inocula were gotten rid of after 2 hours. The cells were rinsed twice with PBS and incubated at 37 ° C for 3 days, and treated with ...
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MUTATIONS INDUCED IN ARABIDOPSIS BY DNA NUCLEOSIDE ANALOGS
... I n addition to these clear mutants, about 10% of the analog treated families and about 5 % of the controls segregated abnormal plants in the progeny (M,).. These were char[r] ...
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Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... There is evidence that mutations that confer resistance to nucleoside analogs reduce viral fitness 12336 Downloaded from http://jvi.asm.org/ on November 8, 2019 by guest Although human i[r] ...
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High Throughput Screening for the Enhancement of Adeno-Associated Virus Type 2 Transduction
... Adeno-associated virus (AAV) is a promising vector for human gene therapy. Although more effective than non-viral vectors, AAV still requires improvement in efficacy in order to become a successful gene therapy vector. ...
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Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... Conversion of viral RNA to double-stranded DNA by re- verse transcriptase (RT) is a defining step in the retroviral life cycle (8) and a key target of therapy for human immunodefi- ciency virus type 1 (HIV-1) infection ...
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Mutations in Coronavirus Nonstructural Protein 10 Decrease Virus Replication Fidelity
... Here we show that mutations in murine hepatitis virus (MHV- A59) nsp10, at positions previously demonstrated to disrupt nsp10-nsp14 interactions in vitro, decrease CoV replication fidel- ity. The nsp10 R80A/E82A-ExoN( ⫹ ...
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Exogenous Cyclic AMP, Cholera Toxin, and Endotoxin Induce Expression of the Lipopolysaccharide Receptor CD14 in Murine Bone Marrow Cells: Role of Purinoreceptors
... Although a number of studies were conducted to analyze LPS signaling in fully differentiated cells, little is known about the signaling pathways by which LPS induces the expression of new surface molecules or receptors ...
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Expression and functional activity of nucleoside transporters in human choroid plexus
... as nucleoside reverse transcriptase inhibitors. Human nucleoside transport protein hENT2, expressed in Xenopus oocytes, mediates transport of 3 ’ -azido-3 ’ -deoxythymidine (AZT), 2 ’ 3 ’ - dideoxycytidine ...
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HIV-1 mutational pathways under multidrug therapy
... to nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors (as listed in the 2008 International AIDS Society report), or which were mutant at therapy start in 5% or more of the ...
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Synthesis of nucleoside analogues
... relationships and may be expected to assume the same conformations as their nucleoside analogues. Thus the carbocyclic derivatives have the potential either to mimic or antagonize the functions of the naturally ...
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Impact of Y181C and/or H221Y mutation patterns of HIV 1 reverse transcriptase on phenotypic resistance to available non nucleoside and nucleoside inhibitors in China
... treatment of HIV-1 infection: nucleoside reverse tran- scriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). Highly active anti- retroviral therapy (HAART) generally ...
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