Nucleoside reverse transcriptase inhibitor (NRTI)
Selection of Resistance in Protease Inhibitor-Experienced, Human Immunodeficiency Virus Type 1-Infected Subjects Failing Lopinavir- and Ritonavir-Based Therapy: Mutation Patterns and Baseline Correlates
... and nucleoside reverse transcriptase inhibitor (NRTI)-experienced, nonnucleoside reverse tran- scriptase inhibitor (NNRTI)-naive patients, maximal virologic response to ...
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Switch rates, time to switch, and switch patterns of antiretroviral therapy in people living with human immunodeficiency virus in Japan, in a hospital claim database
... Entry inhibitor; FTC: Emtricitabine; HIV: Human immunodeficiency virus; HR: Hazard ratio; ICD-10: The International Statistical Classification of Diseases and Related Health Problems 10th Revision; INSTI: ...
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Phylogenetic and Genetic Analysis of Feline Immunodeficiency Virus gag, pol, and env Genes from Domestic Cats Undergoing Nucleoside Reverse Transcriptase Inhibitor Treatment or Treatment-Naïve Cats in Rio de Janeiro, Brazil
... pol reverse transcriptase (RT), and env gp120 (V3-V4) regions were analyzed to determine subtypes and to evaluate potential mutations related to antiretroviral drug resistance among treated ...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ZIDOVUDINE USING SUBLIMATION TECHNIQUE
... as nucleoside reverse transcriptase inhibitors- ...the nucleoside reverse transcriptase inhibitor (NRTI), Zidovudine ...
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Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study
... (PIs), nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors ...with NRTI+NNRTI+ PI, 6 (14.6%) with NRTI+NNRTIs, ...
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Role of etravirine in the management of treatment-experienced patients with human immunodeficiency virus type 1
... non-nucleoside reverse transcriptase inhibitor (NNRTI) with expanded antiviral activity against NNRTI-resistant HIV-1, to be used in combination therapy for treatment-experienced ...
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Rapid and persistent selection of the K103N mutation as a majority quasispecies in a HIV1 patient exposed to efavirenz for three weeks: a case report and review of the literature
... Non-nucleoside reverse transcriptase inhibitor (NNRTI)- based highly active anti-retroviral treatment (HAART) regimens are characterized by a good tolerance of relatively low levels of ...
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HIV-associated cardiovascular disease: importance of platelet activation and cardiac fibrosis in the setting of specific antiretroviral therapies
... protease inhibitor (PI) ritonavir and certain other PI- based ...one nucleoside reverse transcriptase inhibitor, abacavir, activate platelets, but a role for this phenomenon in clinical ...
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<p>Doravirine and Its Potential in the Treatment of HIV: An Evidence-Based Review of the Emerging Data</p>
... non-nucleoside reverse transcriptase inhibitor (NNRTI), is available as a co-formulated single-tablet regimen (STR) including lamivudine and tenofovir disoproxil fumarate (Delstrigo ™ ) and ...
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Volume 2 | Issue 4 - 2012
... 12. Marzolini, C. Telenti, A. Buclin, T. Biollaz, J. and Decosterd. L.A. Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non- nucleoside ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... In the present paper, we are reporting molecular docking and interaction studies of 83 different derivatives of coumarin nucleus with structure of the binding pocket of non nucleoside reverse ...
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"A REVIEW ON PATHOLOGY OF AIDS AND ITS TREATMENT REGIMENS" by Nadeem Siddiqui*, Waquar Ahsan, Priya Ahuja, M. Shamsher Alam, Anwar Habib, India.
... L-cytosine nucleoside analogue reverse transcriptase inhibitor (NRTI) currently under investigation in Phase I/II clinical trials for the treatment of HIV infection and chronic ...
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Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
... Nonnucleoside reverse transcriptase (RT) inhibitors such as nevirapine are highly selective for HIV-1 (50), whereas the nucleoside RT inhibitor (NRTI) azidothymidine (AZT) inhibits ...
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Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
... In the present work molecular docking study was focused on understanding the binding mode of molecules on different crystal structures of HIV-1RT enzyme. The studies have indicated that thiazolidinone ring plays a ...
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Post-exposure prophylaxis for non-occupational exposure to HIV: experience in NSW one year after the introduction of the guidelines
... (two nucleoside reverse transcriptase inhibitors and a protease inhibitor) is ...two nucleoside analogues in most circumstances, with the addition of a protease inhibitor in ...
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Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... two nucleoside reverse transcriptase inhibi- tors (NRTIs) and a nonnucleoside reverse transcriptase inhib- itor (NNRTI) or a protease inhibitor ...
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Nonnucleoside Reverse Transcriptase Inhibitor-Resistant HIV Is Stimulated by Efavirenz during Early Stages of Infection
... The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) converts viral genomic RNA into double- stranded DNA through the process of reverse transcription (reviewed in reference ...
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The impact of a UK HIV-1 resistance database for the management and improvement of the clinical care of people living with HIV-1
... 3TC and NVP on 18/06/2004. The clinician requested a resistance test on a sample from the patient in September 2004 as the patient had a poor response to the treatment regimen, even though they stated their adherence was ...
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Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages
... other nucleoside analogues and also markedly higher in macrophages than in tumor cells ...of nucleoside analogues, including 3TC, in patients with multiple drug resistance and stable plasma viral load ...
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Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders
... Systematic reviews have discussed the impact of ARV agents and regimens on LD, but with discordant conclu- sions. If a clear relationship between NRTIs (thymidine analogs) and LA has been demonstrated, the causal role of ...
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