Nucleoside reverse transcriptase (RT) inhibitors
AZOLES AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIs): MINI REVIEW
... Non-nucleoside reverse transcriptase inhibitors (NNRTIs) in addition with Nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs) ...
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Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... 1(HIV-1) reverse transcriptase codons 41 to 219 in DNA from 127 peripheral blood mononuclear cell samples obtained from 35 patients treated with nucleoside reverse transcriptase ...
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Immunogenicity of Mutations Induced by Nucleoside Reverse Transcriptase Inhibitors for Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Cells
... 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT vari- ants Leu74Val and lamivudine-selected ...
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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
... to nucleoside reverse trans- criptase inhibitors ...HIV-1 reverse transcriptase (RT) usually uses an ATP-de- pendent excision pathway to develop resistance to the nucleoside ...
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Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
... The molecular docking studies were carried out on four crystal structures of RT enzyme (PDB code 1FKP, 1RT2, 2ZD1, 1KLM). The Molecules were ranked on the basis of Docking score and binding energy Table 2. The molecular ...
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Inhibitory activity of 9 phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV 1 as non nucleoside reverse transcriptase inhibitors
... To further identify the target site of BmPCP during the HIV life cycle, the method based on ELISA RT assay was used to detect the inhibition activity of reverse transcrip- tase. Oligo(dT) 15 was immobilized via ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... transcriptase), 1LW2 (T215Y mutant HIV-1 reverse transcriptase) macromolecules. Ligand and Macromolecule interaction studies were carried out using software VLife Molecular Design Suite 4.3.2 (VLife ...
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Prophylactic and therapeutic effect of AZT/3TC in RT-SHIV infected Chinese-origin rhesus macaques
... NRTIs: Nucleoside analogue reverse-transcriptase inhibitors; Ch RM: Chinese-origin rhesus macaque; NHP: Non-human primate; SIV: Simian immunodeficiency virus; NNRTIs: Non-nucleoside ...
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Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002
... for nucleoside re- verse transcriptase inhibitors (NRTIs), of none to 13% for non-nucleoside reverse transcriptase inhibitors (NNRTIs), and of 3% to 7% for protease ...
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The impact of a UK HIV-1 resistance database for the management and improvement of the clinical care of people living with HIV-1
... Appendix 3_Table 9.1d: Demographics, protease (PR) and/ or reverse transcriptase (RT) mutations and drug class impacted (non-nucleoside reverse transcriptase inhibitors (NNRTIs), nu[r] ...
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Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages
... that nucleoside reverse transcriptase inhibitors (NRTIs) are powerful antiviral agents in differentiated macro- phages, reveal that HIV resistance to some NRTIs may be less efficient in these ...
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Impact of Y181C and/or H221Y mutation patterns of HIV 1 reverse transcriptase on phenotypic resistance to available non nucleoside and nucleoside inhibitors in China
... infection: nucleoside reverse tran- scriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors ...
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jsc140003.pdf
... 2 nucleoside reverse transcriptase inhibitors (NRTIs; abacavir/lamivudine or tenofovir disoproxil fumarate/emtricitabine) and a third single or boosted drug, which should be an integrase ...
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The urgent need for more potent antiretroviral therapy in low-income countries to achieve UNAIDS 90-90-90 and complete eradication of AIDS by 2030
... non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz and nevirapine, has been increasing with roll-out of combined antiretroviral therapy (cART) with 29% annual increase in some ...
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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... the reverse transcription during NNRTI exposure include RNase H cleavage, dissociation of NNRTI, and either formation of a PI complex for NNRTI-susceptible phenotype or continuation of polymerization for ...
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Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study
... of nucleoside reverse transcriptase inhibitors (NRTI) and of protease inhibitors (PI) on adipose tissue differentiation and on lipid metabolism have been described ...non-nucleosidic ...
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Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
... Nonnucleoside reverse transcriptase (RT) inhibitors such as nevirapine are highly selective for HIV-1 (50), whereas the nucleoside RT inhibitor (NRTI) azidothymidine (AZT) inhibits infection ...
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Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... the reverse transcriptase open reading frame) were full-length sequenced in sense and antisense orientations by an automated sequencer (ABI 3100) by using seven different overlapping sequence-specific ...
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Susceptibility of the Porcine Endogenous Retrovirus to Reverse Transcriptase and Protease Inhibitors
... triphosphorylated nucleoside analogs of zidovudine (AZT-TP), lamivudine (2⬘,3⬘-deoxy-3⬘-thiacytidine; 3TC-TP), zalcitabine (dideoxycy- tosine [ddC]-TP), stavudine (2⬘,3⬘-didehydro-3⬘-deoxythymi- dine; d4T-TP), and ...
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Non-Hepatic Adverse Effects of Antiretroviral Therapy for HIV Treatment and Care
... Nucleoside Reverse Transcriptase Inhibitors: NRTIs are the backbone of ART and are majorly associated with lactic acidosis and lipodystrophy ...
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