Nucleoside transporter
Ectopic Mineralization of Spinal Tissues in Mice Lacking Equilibrative Nucleoside Transporter 1
... Equilibrative nucleoside transporter 1 (ENT1) regulates the bi-directional transfer of hydrophilic nucleosides, such as adenosine, across the plasma ...
159
High expression of the human equilibrative nucleoside transporter 1 gene predicts a good response to decitabine in patients with myelodysplastic syndrome
... Because the biochemical targets of decitabine are intracellular, the mandatory first step in the production of cytotoxicity is permeation across the cell membrane. Decitabine and physiologic nucleosides are hydrophilic, ...
9
Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG
... Despite exhibiting very low sequence identities, the overall folds of those MFS proteins for which struc- tures are currently available are remarkably similar, and thus it has been proposed that the known struc- tures ...
16
A novel RNA variant of human concentrative nucleoside transporter 1 (hCNT1) that is a potential cancer biomarker
... pyrimidine nucleosides as well as a variety of derivatives used in anticancer and antiviral treatment. hCNT1 is gen- erally downregulated in cancer tissues and suspected of tumor suppressor activity. Here, we report a ...
11
FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia
... a nucleoside analog that requires membrane transport proteins of the human nucleoside transporters (hNT) gene families SLC28 and SLC29 to be internalized into target ...Concentrative Nucleoside ...
14
Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance
... equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most ...
10
Uptake of purines in Plasmodium falciparum infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter
... that nucleoside transport inhibitors, including NBMPR, dilazep and dipyridamole all display intrinsic activity against ...falciparum nucleoside transporter, PfNT1, is 85% inhib- ited by 10 μM ...
10
Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology
... Equilibrative Nucleoside Transporter SLC29 family in the human genome database (8, 9) or the ...the transporter classifi- cation database (10). Nucleoside transporters are present in ...
9
Persistent Hepatitis C Virus Infection Impairs Ribavirin Antiviral Activity through Clathrin-Mediated Trafficking of Equilibrative Nucleoside Transporter 1
... Ribavirin (RBV) continues to be an important component of interferon-free hepatitis C treatment regimens, as RBV alone does not inhibit hepatitis C virus (HCV) replication effectively; the reason for this ineffectiveness ...
17
Human Equilibrative Nucleoside Transporter Subtype 1: Structure-Function Analysis Using Cysteine Mutagenesis and Thiol Modifying Techniques
... alter transporter function and/or inhibitor ...the transporter in one site but with a separate set of determinants, it will be conducive in finding their separate points of ...
201
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
... equilibrative nucleoside transporters (ENTs) terminate adenosine signaling, we observed that pharmacologic ENT inhibition in mice elevated renal adenosine levels and damp- ened ...
19
Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH)
... Warraich S, Bone DB, Quinonez D, Ii H, Choi DS, Holdsworth DW, Drangova M, Dixon SJ, Seguin CA, & Hammond JR (2013) Loss of equilibrative nucleoside transporter 1 in mice leads to [r] ...
143
Host-Based Ribavirin Resistance Influences Hepatitis C Virus Replication and Treatment Response
... minute (cpm) per cell (P ⫽ 0.001). (C) RBV uptake following nucleoside transporter transfection. Cells were transfected with plasmids expressing ENT1, CNT3, or vector. The RBV uptake assay was performed at ...
11
Gene expression of <em>hENT1</em>, <em>dCK</em>, <em>CDA</em>, <em>dCMPD </em>and <em>topoisomerase </em>IIα as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin
... equilibrative nucleoside transporter 1, deoxycytidine kinase, cytidine deaminase (CDA), deoxycytidine monophosphate deaminase (dCMPD) and topoisomerase IIα ...
17
ENT1 and ENT1 mice during both normoxic and hypoxic conditions. Gene expression was
... Adenosine is important in the regulation of vascular tone and the Equilibrative Nucleoside Transporter 1 (ENT1) is a regulator of adenosine concentrations. Thus, changes in ENT1 expression and activity may ...
134
Decreased erythrocyte nucleoside transport and hENT1 transporter expression in glucose 6-phosphate dehydrogenase deficiency
... express nucleoside transporter polypeptides in the plasma membrane to catalyze rapid nucleoside permeation ...equilibrative transporter, hENT1, which shows acute sensitivity towards reversible ...
7
Ormanns, Steffen (2018): Molekulare Dysregulationen und ihre Biomarker im Pankreaskarzinom. Habilitationsschrift, LMU München: Medizinische Fakultät
... Obgleich die große Mehrheit der PDAC aktivierende KRAS-Gen Mutationen aufweist, was auf eine konstitutive Aktivierung des MAPK-Signalweges schließen lässt, zeigen wir im fortgeschrittenen Pankreaskarzinom eine heterogene ...
24
Purine Transport and Metabolism in Microvascular Endothelial Cells
... depth examination of the role of ENT1 (and the effects of its absence) in adenosine metabolism and bioactivity in the various cell types that constitute the cardiovascular system under both normal and pathophysiological ...
322
Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese
... Concentrative nucleoside transporter; Ctrl: Control; F: Frequency; GWAS: Genome-wide association study; HCB: Han Chinese in Beijing; HUA: Hyperuricemia; HWE: Hardy- Weinberg equilibrium; OR: Odds ratio; P: ...
8
Cytosine Arabinoside Influx and Nucleoside Transport Sites in Acute Leukemia
... of nucleoside transport sites was estimated for each cell type by measuring the equilibrium binding of [ 3 H]nitrobenzylthioinosine (NBMPR), which inhibits nucleoside fluxes by binding with high affinity to ...
12