nucleotide binding oligomerization domain 2
Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study
... particular, nucleotide-binding oligomerization domain 2 (NOD2) and mannose-binding lectin (MBL) have been implicated in the pathogenesis of ...
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Muramyl dipeptide activation of nucleotide binding oligomerization domain 2 protects mice from experimental colitis
... recruitment domain 15 (CARD15) mutations and corresponding abnormalities of nucleotide-binding oligomerization domain 2 (NOD2) protein to Crohn disease are still poorly ...
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The diagnostic challenge of very early-onset enterocolitis in an infant with XIAP deficiency
... with Nucleotide binding oligomerization domain 2 (NOD2), we also analyzed IL-8 production in response to muramyl dipeptide (MDP), revealing impaired signaling of this pathway ...
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Analysis of nucleotide binding oligomerization domain proteins in a murine model of pneumococcal meningitis
... This study was performed in strict accordance with the guidelines of the NIH’s Guide for the Care and Use of Laboratory Animals (National Institutes of Health Publica- tion No. 80–23, revised 1996). The protocol was ...
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Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection
... NOD2 regulates specific DC subsets. To further characterize the defective DC responses in Nod2 ⫺/⫺ mice and their effects on CD8 ⫹ T cell responses, we examined specific DC populations in the lungs and draining lymph ...
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Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice
... It has been widely known that Nod1 and Nod2 regulate innate immune response and protect hosts against pulmonary bacterial infections [11,13-15]. However, little is known about the role of the Nod1 and Nod2 pathways in ...
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Effects of polymorphisms in nucleotide-binding oligomerization domains 1 and 2 on biomarkers of the metabolic syndrome and type II diabetes
... the nucleotide-binding oligomerization domains (Nods) 1 and 2 are cytosolic proteins of innate immunity (Girardin et ...repeat domain at the carboxy terminus (Chamaillard et ...
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Nucleotide binding oligomerization domain containing like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila
... Data are expressed as mean ± standard error of mean (SEM). For comparisons of continuous variables among multiple groups, significance was determined using one- way ANOVA with bonferroni post-hoc test analysis. Com- ...
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Nucleotide binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case control study
... The human colorectal cancer cell line Caco-2 was obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). Cells were cultured in Dul- becco's modified Eagle medium (DMEM) with L- glutamine ...
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Immune responses upon Campylobacter jejuni infection of secondary abiotic mice lacking nucleotide-oligomerization-domain-2
... The nucleotide-binding oligomerization domain (Nod)-like receptors comprize an important family of signaling molecules sensing microbial products and damage-asso- ciated factors and thus ...
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The nucleotide binding oligomerization domain containing protein 1 (NOD1) polymorphism S7N does not affect receptor function
... single nucleotide polymorphisms ...in Nucleotide-binding Oligomerisa- tion Domain (NOD) 2 the SNPs R702W, G908R, and 1007fsincC all inhibit receptor activation and predispose to Crohn’s ...
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Campylobacter jejuni infection of conventionally colonized mice lacking nucleotide-oligomerization-domain-2
... The nucleotide-binding oligomerization domain (NOD) like receptors comprize intracellular pattern rec- ognition receptors that regulate host immunity by sens- ing microbial products and ...
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Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins
... and 2), V5- and Flag-tagged forms of the mda-5H domain (lanes 3 and 4), V5- and Flag-tagged forms of the RIG-IC domains (lanes 5 and 6), V5- and Flag-tagged forms of the RIG-IH domain (lanes 7 and ...
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C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation
... N-terminal domain. In mutant FHR1, duplication of the N-terminal domain resulted in the formation of unusually large multi- meric FHR complexes that exhibited increased avidity for the FHR1 ligands C3b, ...
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The inflammasome in leprosy skin lesions: an immunohistochemical evaluation
... H 2 O 2 for 45 ...Nonspecific binding sites were blocked with 10% concentrated skim milk for 30 ...H 2 O 2 , counter- stained with Harris hematoxylin for 1 minute, then hydrated in ...
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Higher-Order Septin Assembly Is Driven by GTP-Promoted Conformational Changes: Evidence From Unbiased Mutational Analysis in Saccharomyces cerevisiae
... structural modeling suggests that the pocket of Cdc12 (G247E) could accommodate the pyrimidine triphosphate CTP (C. Musselman, unpublished observations). We propose that GTP binding per se by Cdc12 is not critical ...
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T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.
... weight range indicating that multimeric antigen was also present. A PfAMA1-IMX313 heptamer has an expected molecular weight of approximately 570 kDa. Although it is impossible to tell whether this species was precisely ...
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Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating
... M, respectively, comparable to values (0.2 s 1 , and 0.3–1 mM) found for intact CFTR (Li et al., 1996). Bar- ring inadvertent contamination of the NBD1 prepara- tions by copurifying ATPases, a possible explanation is ...
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Different mechanisms of two anti anthrax protective antigen antibodies and function comparison between them
... The pathogenesis of B. anthracis is mainly caused by anthrax toxin which is a tripartite protein complex. The three-protein toxin consist of a cellular receptors bind- ing component, the protective antigen (PA), and two ...
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Multi-scale modeling of the structure and dynamics of macromolecules
... The mechanism of other cytoskeletal motors such as myosin and kinesin, are better studied and more understood. It has been shown that nucleotide-driven conformational changes of their mechanism elements power the ...
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