Nucleotide Excision-Repair
Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... of nucleotide excision repair (NER) proteins in removing UV-induced lesions are well ...base excision repair (BER) genes during abasic (AP) site repair of Schizosaccharo- myces ...
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Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts
... the nucleotide excision repair (NER) pathway ...genomic repair (GGR), which removes lesions genome-wide, and transcription-coupled repair (TCR), which removes lesions specifically from ...
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Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents
... for nucleotide excision repair (NER) is a major determinant of the efficacy of and resistance to DNA-damaging chemotherapeutics, such as ...cisplatin repair and vice ...DNA repair ...
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The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway
... superfamily 2 helicase and the founding member of a family of DNA helicases with iron–sulphur cluster domains. As a component of transcription factor II H (TFIIH), XPD is involved in DNA unwinding during ...
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Nucleotide excision repair pathway gene polymorphisms are linked to breast cancer risk in a Chinese population
... in nucleotide excision repair (NER) pathway genes are associated with the risk of breast cancer, but the relevance of these associations appeared to vary according to the ethnicity of the ...
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Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery
... Excision repair cross-complementing group 1 (ERCC1) is involved in nucleotide excision repair pathway that eliminates bulky DNA adducts caused by carcinogens in tobacco smoke and ...
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The association of six polymorphisms of five genes involved in three steps of nucleotide excision repair pathways with hepatocellular cancer risk
... XPA was the first human NER protein showing a preference for binding to damaged DNA. It is also a zinc- binding protein with affinity for various DNA damage [14] that functions at the core of the NER system [15]. XPA is ...
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Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus
... the nucleotide excision repair was measured in six patients with quiescent disease and their matched ...of nucleotide excision repair at the N- ras locus strongly correlates with ...
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Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein
... An HCR assay (1) was also used to measure the effect of Tax on NER (Fig. 1B). In this assay, a reporter plasmid was UV treated to induce DNA damage prior to transfection. HCR is a particularly good measure of NER since ...
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Original Article Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population
... Larynx cancer is an important entity of cancer, which accounts for 30%-40% of all malignant head and neck tumors [1, 2]. It is estimated that the there were 138,102 new cases with laryngeal cancer and 73,261 deaths from ...
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Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans
... DNA repair declines with age in mammals [24,25]. We found that repair in all ten nuclear targets was lower in aging (6 days after L4) adults than repair of those same targets in young (1 day after ...
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Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.
... the nucleotide excision repair (NER) DNA repair pathway (35, ...genome repair pathway as part of a complex with the xero- derma pigmentosum complementation group C protein (XPC) ...
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Original Article Genetic polymorphisms in nucleotide excision repair pathway influences response to chemotherapy and overall survival in osteosarcoma
... DNA repair to restore genom- ic integrity, and DNA repair pathway involves a number of DNA repair genes [16, 17], and these genes are responsible for different functions of DNA repairing ...
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High ERCC1 expression predicts cisplatin based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel chewing area
... the nucleotide excision repair pathway which arms to guard the integrity of the genome ...enzyme excision repair cross-complementa- tion group 1(ERCC1) plays a rate limiting role in the ...
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The archaeal RecJ like proteins : nucleases and ex nucleases with diverse roles in replication and repair
... base excision repair and mismatch repair, while in eukaryotes, the RecJ-like protein Cdc45 (which has lost its nuclease activity) is a key component of the CMG (Cdc45-MCM-GINS) complex, the ...
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Characterisation of unusual DNA glycosylases from Trichomonas vaginalis
... substrate excision between Hx and alkylated ...abasic nucleotide (pyr), to investigate how AAG was able to recognise and excise so many substrates that are not structurally similar and do not all distort ...
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DNA repair in the archaea – an emerging picture
... In eukaryal NER, XPD has been shown to “proofread” for the presence of a DNA lesion in the translocated strand as a mechanism to increase the specificity of the NER reaction (Mathieu et al., 2013). A lesion recognition ...
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The Unexpected Existence of Coding and Non Coding Fragments along the Eukaryotic Gene
... a repair patch (RP) located along given promoters or introns (1), it could happen that a symmetrically dimethylated 5’-m 5 CG- 3’/3’-Gm 5 C-5’ dinucleotide pair would flank a UV-induced TT-dimer (2); after ...
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Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers
... base excision repair (measured as the capacity of the lymphocyte extract to repair 8-oxoGua ex ...base excision repair capacity in those volunteers with the lowest preintervention ...
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Comparative study of preservation Versus elective division of ilioinguinal nerve in open mesh repair of inguinal hernia
... a single groin hernia for use with local anaesthesia. The essential feature of GPRVS is the reinforcement of the transversalis fascia in the groin by a large prosthesis that extends far beyond the myopectineal orifice of ...
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