OLETF rat
Anti Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
... Materials and Methods: Primary cultures of male Otsuka Long-Evans Tokushima Fatty (OLETF) rat VSMCs were obtained from enzymatically dissociated rat thoracic aortas. VSMCs were incubated for 72 h ...
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Exercise preserves pancreatic β-cell mass and function in obese OLETF rats
... the OLETF rats which is consistent with the observations that the exercise signi icantly reduced the β-cell apoptosis in these ...the OLETF rats suggesting that declined glucolipotoxicity might have, at ...
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Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF Rats
... male OLETF rats and LETO rats, the progenitor of OLETF rats, were provided by Tokusima Research Institute (Otsuka Pharmaceutical, Tokushima, ...period, OLETF rats were assigned to two groups (six ...
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Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats
... during the measurement. As the results, the total oxygen consumption and energy expenditure were not altered by dietary resveratrol at 1 week or 3 weeks of feeding (data not shown). However, carbohydrate oxidation ...
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Binge Alcohol Consumption Aggravates Oxidative Stress and Promotes Pathogenesis of NASH from Obesity-Induced Simple Steatosis
... The pathogenesis of nonalcoholic steatohepatitis (NASH) is a two-stage process in which steatosis is the “first hit” and an un- known “second hit.” We hypothesized that “a binge” could be a “second hit” to develop NASH ...
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Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivo
... Results: In the first experiment, we found that soy crude peptide (SCP)-LD3, which was prepared by hydrolyze of soy protein isolate with endo-type protease, showed hypolipidemic effects in HepG2 cells and OLETF ...
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Rodent models of diabetic nephropathy: their utility and limitations
... useful for the study of early stages of diabetic nephropathy. However, animal models have limited utility for understand- ing the pathogenesis of advanced diabetic nephropathy, in part because there is no ideal model ...
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Reduced Food Intake is the Major Contributor to the Protective Effect of Rimonabant on Islet in Established Obesity Associated Type 2 Diabetes
... In OLETF rats, a markedly high level of HOMA- IR was observed in control group after 6 weeks of ...and OLETF rats, serum adiponec- tin levels were highest in the rosiglitazone group ...In OLETF rats, ...
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Detailed Localization of Augmented Angiotensinogen mRNA and Protein in Proximal Tubule Segments of Diabetic Kidneys in Rats and Humans
... prepared OLETF rats treated with angiotensin II type 1 receptor blocker, olmesartan or with a combination of vasodilator ...the OLETF rats compared with the LETO ...the OLETF rats compared with the ...
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Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats
... in OLETF groups increased significantly from week 30 than that in the LETO group, and among the OLETF groups, TC level was significantly lower in the O-P group than in the O-C group at 50 and 60 weeks ( ...
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Does Ethanol Play a Pro Oxidant Role during Oxidative Stress in the Liver?
... a rat hepatoma cell line (FTO2B) and rat primary hepatocytes in cul- ture in the presence or absence of ethanol ...primary rat hepatocytes with ethanol and tBH increased cell ...
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Non Obese Type 2 Diabetic Rat Models GK Rat and SDT Rat
... one of the most severe ocular complications. Currently, there is no animal mod- els show neovascular glaucoma. SDT rats with advanced retinopathy developed fibrovascular membrane around the iris and sometimes with ...
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Characterization of an Orthotopic Rat Model of Glioblastoma Using Multiparametric Magnetic Resonance Imaging and Bioluminescence Imaging
... compare longitudinal BLI and mpMRI data in untreated orthotopic C6 rat glioma with histology at end-point. Current literature provides little information to how BLI and mpMRI metrics of tumour burden relate in the ...
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Glucocorticoid activation of chromogranin A gene expression Identification and characterization of a novel glucocorticoid response element
... the rat chromogranin A promoter to elucidate transcriptional regulation of chromogranin A biosynthesis by glucocorticoids in neuroendocrine ...Transfected rat chromogranin A promoter/luciferase reporter ...
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Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder
... The PDE3 family contains two subfamilies, PDE3A and PDE3B, which are encoded by distinct but related genes [11]. PDE3A and PDE3B isoforms are widely expressed but also exhibit tissue-specific patterns. For example, PDE3A ...
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Determination of site of absorption of propranolol in rat gut using In situ single-pass intestinal perfusion
... Previously, permeability and site of intestinal absorption of propranolol have been reported using the Ussing chamber. In the present study, the utility of Single-Pass Intestinal Perfusion to study permeability and site ...
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Cytochemical localization of Na+, K+ ATPase in the rat hepatocyte
... localized to the luminal side of the membrane. These findings indicate that Na+,K+-ATPase is localized to the sinusoidal and lateral portions of the rat hepatocyte plasma membrane and is not detectable on the bile ...
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Alpha 1 adrenergic receptor induced c fos gene expression in rat aorta and cultured vascular smooth muscle cells
... demonstrated that rat aorta prominently expressed mRNA for alpha 1B and alpha 1A/D receptors. Phenylephrine-induced c-fos mRNA was partially inhibited by H-7, a protein kinase C inhibitor, and by nifedipine, a ...
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Original Article FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression
... bitor that inhibits CaN activity by binding to the FK binding protein (FKBP) domain [38]. According to a literature review, the renoprotec- tion by FK506 may be at least partly related to the suppression of TRPC6 and ...
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Mutational analysis of human papillomavirus type 16 E7 functions.
... Whereas the immortalizing function transformation in conjunction with activated ras for primary rat cells paralleled the transforming function for rat 3Y1 cells, the transformation funct[r] ...
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