Oligodendrocyte progenitor
Collagen microsphere serving as a cell carrier supports oligodendrocyte progenitor cell growth and differentiation for neurite myelination in vitro
... the oligodendrocyte progenitor cells (OPCs), which produce the proteoglycan NG2 and express the platelet-derived growth factor- α receptor on the cell membrane, are recruited from gray and white matter and ...
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Transdifferentiation of human adipose-derived mesenchymal stem cells into oligodendrocyte progenitor cells
... expressed oligodendrocyte progenitor cells markers [A2B5 and oligodendrocyte transcription factor (Olig2)] which were significantly higher than myelin basic protein (MBP) which is mature ...
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The voltage gated calcium channel CaV1 2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
... OPCs express various receptors and ion channels that enable them to respond to changes in neuronal activity by increasing intracellular cal- cium (reviewed by Pitman and Young (2016)), however, there is lim- ited ...
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What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury?
... kind, oligodendrocyte progenitor cells (OPCs) derived from human embryonic stem cells (hESCs) will be injected into the spinal cords of patients with an acute thoracic SCI to assess safety and efficacy in ...
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Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation
... human oligodendrocyte progenitor cells at 3 months ...human oligodendrocyte progenitor cells (hOPCs; red) had differentiated into glial fibrillary acidic protein (GFAP(+)) astrocytes (green) ...
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Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats
... of oligodendrocyte progenitor ...dominantly oligodendrocyte precursors are damaged we now extended these investigations by analyzing whether corticosteroids exert a protective effect on survival, ...
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Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation
... + oligodendrocyte density increased in Cdk2−/− mice 1 and 2 weeks later, a delay cor- responding to the onset of remyelination and the oligo- dendrocyte/myelin regeneration period in LPC lesions, ...
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Conditionally and acutely ablating Kif3a from oligodendrocyte progenitor cells impairs primary cilum assembly and cell function
... An area of significant interest in the myelin biology field at present, is understanding the purpose of adult oligodendrogenesis (Waly et al., 2014; Wang and Young, 2014). Herein, I demonstrate that acutely reducing OPC ...
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Phase 1 trial of autologous bone marrow stem cell transplantation in patients with spinal cord injury
... human oligodendrocyte progenitor cells (OPCs), Schwann cells, bone marrow stromal cells, nasal olfactory ensheathing cells and others are being used for stem cell therapy during spinal cord ...expressed ...
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Decrease in Cavity Size and Oligodendrocyte Cell Death Using Neurosphere-Derived Oligodendrocyte-Like Cells in Spinal Cord Contusion Model
... in oligodendrocyte progenitor-like cells ...differentiate oligodendrocyte progenitor-like cells into OLCs, the cells were inducted with triiodothyronine in 5% CO 2 at ...
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How to make an oligodendrocyte
... brain-derived oligodendrocyte progenitor cells. Oligodendrocyte progenitor cells (OPCs) can be readily derived from pluripotent stem cells, including both human embryonic stem cells (hESCs) ...
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An oligodendrocyte specific zinc finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation
... cultured oligodendrocyte progenitor cells from neonatal rat forebrain and the CG4 oligodendroglial cell line (kindly provided by Dr Robin Miskimins) using Trizol (Invitrogen, Carlsbad, ...
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Oligodendroglia: metabolic supporters of neurons
... from oligodendrocyte progenitor cells (OPCs, also called NG2-glia), which populate the CNS starting from embryonic development onward ...The oligodendrocyte- produced myelin sheath is classically ...
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Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy
... neural progenitor cell; NSC: neural stem cell; OEC: olfactory ensheathing cell; OPC: oligodendrocyte progenitor cell; PBS: phosphate-buffered saline; PCR: polymerase chain reaction; PDGF: ...
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The relationship between proliferation and differentiation during oligodendrocyte development
... Although the timing component of the timer is defective in p27- deficient animals, oligodendrocytes do develop after a delay of around one or two days (Durand et a l, 1998). These results suggest that other, as yet ...
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Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica
... We monitored the kinetics of neuron, oligodendrocyte, and astrocyte death in the mixed cultures following tar- geted rAb #53-mediated astrocyte damage with IncuCyte live cell imaging. No cell death was noted with ...
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Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1
... an oligodendrocyte or astrocyte ...the oligodendrocyte lineage, we also examined astrocytes in Ascl1 GFPKI/GFPKI mutants using Aldh1L1 to mark ...directing oligodendrocyte versus astro- cyte ...
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A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells
... Benztropine, donepezil, oxybutynin, vesamicol, and ipratropium all perturb the muscarinic acetylcholine signaling pathway. Indeed, the muscarinic receptor path- way has been previously implicated in OL differentia- tion ...
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Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points
... and progenitor cells, but do not represent a “default” developmental ...and progenitor populations and requires more extensive changes to the transcriptional and epigenetic programs to permit ...
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Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation
... Together, these data suggest that ET-1 is prominently associated with reactive astrocytes during EAE disease remission in WT and anti-TNF- treated GFAP γ R1 Δ mice but is significantly i[r] ...
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