Oral absorption
Development of a novel microemulsion for oral absorption enhancement of all-trans retinoic acid
... the oral absorption of all-trans retinoic acid ...intestinal absorption, intestinal membrane cytotoxicity and ...intestinal absorption of ...
15
Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system
... enhance oral absorption of tacrolimus (FK506) with minimal use of oil, surfactant, and ...vivo oral absorption with conventional SEDDS, with minimal use of vehicle ...
9
Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate
... after oral administration of cilostazol-free base, cilostazol mesy- late, and cilostazol besylate to rats are shown in Figure ...rapid oral absorption and shorter T max compared to the ...
8
Apically targeted oral micelles exhibit highly efficient intestinal uptake and oral absorption
... and oral absorption of PepT-1-mediated micelles (Val-PMs or Phe-PMs) were investigated, with the Cur solution (Cur-Sol) and non-PepT1-targeting micelles (TP- PMs) as ...and oral absorption of ...
16
Mechanism of enhanced oral absorption of hydrophilic drug incorporated in hydrophobic nanoparticles
... Abstract: Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L, which has high water solubility and low oral bioavailability. This research aims to develop a ...
9
Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation
... intestinal absorption of carvedilol nanosuspensions was greatly improved in comparison with microsuspensions and solution in the in situ single-pass perfusion ...the oral absorption of carvedilol ...
10
EXPLORING THE ORAL ABSORPTION ENHANCING EFFECT OF PIPERINE AND CHITOSAN ON TENOFOVIR LOADED SOLID LIPID NANOPARTICLES
... the oral absorption enhancing effect of piperine and chitosan on tenofovir loaded solid lipid nanoparticles” investigated the possibility of enhancement of absorption of poorly absorbed drug TDF ...
6
Comparison of oral absorption models for pregabalin: usefulness of transit compartment model
... the absorption profile for the PK data obtained after overnight fasting was markedly different from that after a meal, the absorption parameters were estimated separately (Table ...
9
DESIGN AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES OF GANCICLOVIR FOR IMPROVED ORAL ABSORPTION
... by oral route is limited as a result of its low oral ...novel oral delivery system in the form of solid lipid Nanoparticles (SLN) overcomes these ...
14
Oral absorption of PEG-coated versus uncoated gold nanospheres: does agglomeration matter?
... While PEG-coating may have potentially been advan- tageous to transit the thick mucin layer, there is evidence that PEG-coating can decrease macrophage uptake of iron particles and that longer chain lengths increase ...
13
6206.pdf
... decreased absorption of metformin is masked by the wide therapeutic window of metformin that results in increased dosing of metformin when its desired pharmacodynamic effects are not ...metformin oral ...
152
<p>Solutol<sup>®</sup>HS15+pluronicF127 and Solutol<sup>®</sup>HS15+pluronicL61 mixed micelle systems for oral delivery of genistein</p>
... after oral administration may be attributed to the following reasons: (1) Pluronics and HS15 result in a formulation with a very fi ne nanoparticle size that could improve absorption and permeation of GEN; ...
10
The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices
... and N-Cal remained in the particulate form in vitro and in vivo, regardless of particle size, although slight surface smoothing was observed in biological systems due to corona formation. N-Cal was found to interact more ...
21
“SOLUBILITY ENHANCEMENT TECHNIQUES” by Varun Raj Vemula*, Venkateshwarlu Lagishetty, Srikanth Lingala, India.
... administration. The pharmaceutical form is always liquid. Poorly soluble compounds which are lipophilic or highly crystalline that have a high solubility in the solvent mixture may be suited to a co-solvent approach. Co- ...
11
FORMULATION AND DEVELOPMENT STRATEGIES FOR DRUGS INSOLUBLE IN GASTRIC FLUID
... As a matter of fact, more than one-third of the drugs listed in the U.S. Pharmacopoeia fall into the poorly water-soluble or water-insoluble categories. It was reported a couple of decades ago that more than 41% of the ...
8
Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape
... GS25, oral administration of GS25 (100 mg/kg) caused a very low peak value of drug concen- tration ...mg/kg oral doses of GS25 NPs increased to ...to oral administration of GS25 at a dose of 100 ...
31
Nanotechnology based Oral Delivery of Insulin – A Retrospect
... The absorption of the nanoparticles was thoroughly reviewed by des Rieux [27]. A particle can traverse the intestinal epithelium by the paracellular (between cells) or transcellular route (through the cells). The ...
7
Pre-Formulation Study for Palatable Microbeads of Lycopene
... Lycopene is a red colour component extracted from tomatoes, watermelon and other fruits. Till date, a lot of research has been done to prove its antioxidant property but a successful dosage form for such a health ...
8
The Physiological Disposition and Metabolic Fate of Cortisone in Man
... Absorption of cortisone Following oral administration, as with intravenous infusion, 30 to 40 per cent of the administered steroid was recovered in the urine as metabolites of cortisone [r] ...
13
The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery.
... targeted oral drug delivery ...if oral administration is a feasible approach to delivering intact nanomedicines to the systemic circulation, or if simpler methods (ie intravenous or intramuscular injection) ...
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