oral bioavailability
Naproxen-Soluplus® Nano formulations for Enhanced Oral Bioavailability
... Naproxen-Soluplus Nanoformulations (NFs) prepared via wet milling, using a conventional Retsch Planetary ball mill have been studied for their phase solubility behavior, physico-chemical characteristics, cytotoxicity, ...
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Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation
... the oral bioavailability of baicalin, the plasma drug concentration in rats was determined by HPLC to evaluate the pharmacokinetic behavior of BAN-1 and BAN-2 in comparison with free baicalin suspension ...
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Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers
... Abstract: Nanostructured lipid carriers (NLCs) have been one of the systems of choice for improving the oral bioavailability of drugs with poor water solubility. In the present study, lovastatin ...
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Pharmacokinetics and oral bioavailability of metformin hydrochloride in healthy mixed-breed dogs
... and oral bioavailability of metformin in healthy dogs is lacking, the purpose of the present study was to determine those ...daily oral dose of metformin currently used in anti- cancer clinical ...
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Absolute oral bioavailability and disposition kinetics of puerarin in female rats
... Background: Pueraria candollei var . mirifica is a medicinal plant that is promoted as a “ Champion Product ” by the Government of Thailand. This plant has been reported to relieve postmenopausal symptoms, prevent and ...
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RECENT APPROACHES OF SOLID DISPERSION: A NEW CONCEPT TOWARD ORAL BIOAVAILABILITY
... This process involves immersing the drug carrier solution in liquid nitrogen until the solution at frozen state. Then, the frozen solution is then lyophilized. The best advantage is that it reduces the risk of phase ...
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Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles
... of oral sustained-release sys- tems that can not only improve drug bioavailability leading to better efficacy and less administration frequen- cies but also decrease the fluctuation of plasma drug con- ...
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Nanostructured lipid carriers: A platform to lipophilic drug for oral bioavailability enhancement
... are many different factors which decrease the degree of absorption of lipophilic drugs. Several lipophilic drugs are candidates for efflux transporters such as P-glycoprotein (P- gp) and are also frequently predisposed ...
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Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide
... However, pharmacokinetic data for the HP- β -CD system and solid dispersion technology are lacking; thus, their effects on the absorption of AG cannot be confirmed. High surfactant concentrations in the SMEDD formulation ...
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Improving the oral bioavailability of beneficial polyphenols through designed synergies
... low oral bioavailability, which is thought to be partly due to the actions of the MRP efflux pumps [29, ...the oral bioavailability of EGCG, and putatively, its beneficial activity on human ...
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Enhanced oral bioavailability of cyclosporine A by liposomes containing a bile salt
... enhanced oral bioavailability of CyA by lipid-based vehicles was that the intact liposomal vesicles may promote the uptake by M-cells in the Peyer’s patches and increase the absorption through the lymphatic ...
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Investigation of Different Formulation Approaches to Enhance Oral Bioavailability of Paromomycin
... the oral bioavailability through formulation development for increased patient compliance and ...and oral administration of paromomycin in mice to evaluate different formulation approaches to ...
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Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin
... the oral bioavailability of poorly soluble ...the bioavailability of FVT were proposed: 1) the nanosuspensions of FVT/HP- β -CD dramatically improved the dissolution of the drug and 2) the excipients ...
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Carvedilol solid dispersion for enhanced oral bioavailability using rat model
... absolute bioavailability following oral administration is only ~25% because of its slow dissolution rate and extensive first pass metabolism (Lee, ...low oral bioavailability due to its ...
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Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles
... 2500.00 ng/ml and applied to pharmacokinetic analysis in future. This method has advantages over other reported method that it contains very low concentration for detec- tion of DOX in plasma (i.e. LLOQ 1.00 ng/ml). ...
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Oral bioavailability of cantharidin-loaded solid lipid nanoparticles
... However, CA causes intense mucous membrane irrita- tion [8]. It has been reported that mis-ingestion of CA causes the oral mucous membrane to ulcerate [9]. In clinical therapeutics, gastrointestinal indisposition ...
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Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique
... An attempt has thus been made to design, develop, and char- acterize a novel oil/water ME system of GM that may improve its oral bioavailability. Glimepiride microemulsion (GMME) was prepared according to ...
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Experimental determination of the oral bioavailability and bioaccessibility of lead particles
... of bioavailability have been proposed for soil and sediments ...“oral bioavailability” refers to the amount of ingested Pb that reaches the systemic circulation and that is likely to ac- cumulate in ...
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The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
... the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with ...after oral administration of daidzein-loaded phospholipid complexes PLGA ...
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Self Emulsifying Drug Delivery System: An Approach To Enhance Oral Bioavailability
... of oral bioavailability enhancement are ...human bioavailability studies, as well as more basic studies on the mechanisms of action of this fascinating and diverse group of ...
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