organ-specific
“Viral déjà vu” elicits organ specific immune disease independent of reactivity to self
... mimicked organ- specific autoimmunity in WT inbred mouse strains, this concept — just like the other postulates (20–23) — awaits formal testing and verification in human autoimmune diseases ...
11
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
... at specific organ ...in specific organs and promote organ-specific ...and organ-specific metastasis in malignant melanoma and the inhibitors that have been considered for ...
14
Suppressing immunotherapy by organ-specific tumor microenvironments: what is in the brain?
... It has long been known that CD8+ effector T cells have cytolytic capability that kills cancer cells [11]. In-depth understanding of the T cell biology took off in the 1980–1990s, which included the discovery of T cell ...
8
miR 146a modulates autoreactive Th17 cell differentiation and regulates organ specific autoimmunity
... investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR- 146a has emerged as a critical modulator of immune reactions, but its role in regulating ...
16
Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells
... Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtype, which may involve activation of a host organ-specific signaling network in metastatic cells. To test this ...
15
LYN and AIRE mediated tolerance checkpoint defects synergize to trigger organ specific autoimmunity
... however, how these factors interact and through which tolerance pathways they operate generally remain to be defined. One key checkpoint occurs through the activity of the autoimmune regulator AIRE, which promotes ...
15
A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells
... of specific organs is a key step in hematogenous metastasis [39, ...multiple organ model provided a novel platform for the study of organ- specific metastasis of ...
12
Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies
... For the purpose of the meta-analysis, we included all reproducible correlations, i.e. correlations that received a global p value of <0.1 (note that this threshold was high because there were very few correlations ...
16
Antimicrobial susceptibilities of specific syndromes created with organ specific weighted incidence antibiograms (OSWIA) in patients with intra abdominal infections
... In 2012, Tabah et al. conducted a prospective, multi- centre non-representative cohort study in 162 intensive care units (ICUs) in 24 countries, and showed that MDR and pan-drug-resistance (PDR) was increased in Europe, ...
7
Organ-Specific Silencing of Duplicated Genes in a Newly Synthesized Cotton Allotetraploid
... Most eukaryotes have undergone genome doubling at least once during their evolutionary history. Hybridization followed by genome doubling (allopolyploidization) is a prominent mode of speciation in plants, leading to ...
10
Distinct organ specific metastatic potential of individual breast cancer cells and primary tumors
... Genome-wide variation correlates with organ-specific metastatic phenotype. Because the presence of the poor-prognosis signature of the various SCPs does not strongly correlate with any recognizable aspects ...
13
Organ specific roles for transcription factor NF κB in reovirus induced apoptosis and disease
... an organ- specific role for NF-κB in the regulation of reovirus-induced apoptosis, which modulates encephalitis and myocarditis associated with reovirus ...
11
Organ specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide
... against organ-specific self-peptides bound to MHC ...Ab specific for the I-A b –Ea52-68 complex inhibited disease manifestation in the susceptible ...
9
Literature optimized integration of gene expression for organ-specific evaluation of toxicogenomics datasets
... The organ-specific study of drug effects on human physiology, while necessary, is however difficult given the impossibility of systematically testing the human ...of specific drug effects have been ...
21
Organ specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA
... in organ-specific gene expression, regulating, for example, glucagon expression in the pancreas, GLUT2 expression in the liver, and tyrosine hydroxylase expression in dopaminergic ...neurons. ...
12
GATA4 dependent organ specific endothelial differentiation controls liver development and embryonic hematopoiesis
... their organ-specific vascular niches through angiocrine factors, which include secreted growth factors (angiokines), extracellular matrix molecules, and transmembrane ...drive organ-specific ...
17
Reactive oxygen species in organ-specific autoimmunity
... four organ specific autoimmune diseases (Hashimoto thy- roiditis, inflammatory bowel disease, multiple sclerosis, and vitiligo), and compare it to that of a better character- ized systemic autoimmune ...
11
Organ-specific SPECT activity calibration using 3D printed phantoms for molecular radiotherapy dosimetry
... the organ geometry; however, a reduction in organ dose of 11 and ...using organ-specific calibration factors compared to a 113-ml spherical calibration ...
11
Dissecting organ-specific transcriptomes through RNA-sequencing
... essential organ for energy capturing and primary metabolism, as more genes were transcribed in higher quantities than those in ...accumulating organ-specific secondary compounds such as ...
17
Organ-specific barcodes in human fetal development and stem cell differentiation : the pancreas in the spotlight
... isogenic organ sets showed that organ-specific DNA methylation patterns during the same period of development were highly dynamic with strong organ-specific increases in both hypometh- ...
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