osteoclast differentiation
Hypoxic regulation of osteoclast differentiation and bone resorption activity
... of osteoclast activation results in pathological bone loss, which occurs in conditions including osteoporosis, rheumatoid arthritis, primary bone cancer, and cancer metastasis to ...of osteoclast ...
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Cells in regenerating deer antler cartilage provide a microenvironment that supports osteoclast differentiation
... chondrocytes since antler cartilage also contains a population of perivascular cells that have yet to be fully characterised. Osteocalcin, a bone-specific protein expressed by differentiated osteoblasts, is not expressed ...
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Effect of amorphous silica nanoparticles on in vitro RANKL induced osteoclast differentiation in murine macrophages
... on osteoclast differentiation in ...of osteoclast differ- entiation, was ...in osteoclast differentiation)- treated ...of osteoclast differentiation by RANKL and silica ...
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Water-soluble fullerene (C60) inhibits the osteoclast differentiation and bone destruction in arthritis
... In arthritis, especially in RA, bone destruction progresses with advancing inflammation. We therefore examined whether C60 suppressed osteoclast differentiation and osteo- clastic bone resorption in vitro. ...
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MMP 13 stimulates osteoclast differentiation and activation in tumour breast bone metastases
... pre-osteoclast differentiation and ...pre-osteoclast differentiation and resorption ...the differentiation of TRAP positive cells in bone marrow and within the tumour mass as well as ...
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Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low turnover osteopenia
... We recently identified a new gene, klotho, which is involved in the suppression of multiple aging phe- notypes. The mouse homozygous for a disruption of the klotho locus (kl/kl) exhibited multiple patho- logical ...
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Earthworm (Pheretima aspergillum) extract stimulates osteoblast activity and inhibits osteoclast differentiation
... on osteoclast proliferation and differentiation were evaluated using murine monocyte/ macrophage RAW ...incubation, osteoclast differentiation from RAW ...culture, osteoclast ...
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Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
... RANKL-induced osteoclast differentiation To determine whether WEAO affects osteoclast differenti- ation, we examined the effect of WEAO on RANKL- induced osteoclast differentiation from ...
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Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
... (Figure 2C), this concentration of zinc does not affect BMM viability (Figure 1A). As shown in Figure 2B, the number of fused multinucleated osteoclasts significantly decreased upon zinc treatment, indicating that zinc ...
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Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation
... in osteoclast precursor survival and proliferation and in osteoclast differentiation, respectively ...during osteoclast pro- liferation and ...between osteoclast pre- cursor ...
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Bone marrow derived extracellular vesicles activate osteoclast differentiation in traumatic brain injury induced bone loss
... and/or repetitive mild TBI. These later studies may have direct relevance to athletes in contact sports and military personnel that are at risk of TBI. A potential caveat is the use of young, otherwise healthy male mice. ...
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Original Article Identification of potential PDZ-domain proteins downstream of ephrinB2 reverse signaling during osteoclast differentiation of RAW264.7 cells
... for osteoclast dif- ...RANKL-induced osteoclast differentiation in ...for osteoclast differentiation [37, ...clast differentiation of ...RANKL-induced osteoclast differen- ...
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Involvement of toll-like receptor 2 and 4 in association between dyslipidemia and osteoclast differentiation in apolipoprotein E deficient rat periodontium
... Studies have shown positive association between dyslipidemia and periodontal disease [21,29,30]. In our previous animal study, feeding with a high-cholesterol diet increased serum lipid peroxidation and the number of ...
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Critical roles of c Jun signaling in regulation of NFAT family and RANKL regulated osteoclast differentiation
... in osteoclast formation and bone ...regulates osteoclast differentiation by activating receptor activator of NF-κB and associated signaling molecules, the molecular mechanisms of RANKL-regulated ...
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Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF κB and mitogen activated protein kinase pathways
... This experiment further employed inhibitors to verify the connection between JNK, ERK, and p38 MAP kinase regarding the behavior of RPR. The differentiation of murine RAW264.7 cells into TRAP-positive multi- ...
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Noncanonical G Protein Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin
... IMPORTANCE Pasteurella multocida toxin (PMT) induces degradation of nasal turbinate bones, leading to the syndrome of atro- phic rhinitis. Recently, the molecular mechanism and substrate specificity of PMT were ...
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Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation
... and osteoclast differentiation in bone marrow ...OC differentiation in RAW264.7 cells [36] but in- hibits differentiation in cultured human peripheral blood mononuclear cells (PBMCs) ...the ...
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Bone loss: Factors that regulate osteoclast differentiation an update
... of osteoclast precursors from haematopoietic ...and osteoclast differentiation and represent an evident point of control of bone ...only osteoclast activity, but also osteoclast ...by ...
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HDAC6 regulates dental mesenchymal stem cells and osteoclast differentiation
... suppress osteoclast differenti- ation ...with osteoclast maturation by controlling podo- some patterning through microtubule acetylation in osteoclasts ...and osteoclast differentiation is ...
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RIP140 in monocytes/macrophages regulates osteoclast differentiation and bone homeostasis
... in osteoclast differentiation, we performed a gain-of-function study in RANKL-stimulated ...RANKL-induced osteoclast dif- ...and osteoclast gene expression (Fig- ure 5, B and ...mature ...
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