osteoprotegerin/RANKL
Biology of RANK, RANKL, and osteoprotegerin
... remodeling. RANKL/RANK signaling regulates the formation of multinucleated osteoclasts from their precursors as well as their activation and survival in normal bone remodeling and in a variety of pathologic ...to ...
7
Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits
... of osteoprotegerin/ receptor activator of nuclear factor-κ B/RANK ligand (OPG/RANK/RANKL) has been described as critical in controlling osteoclast ...biology. RANKL, synthesized by osteoblasts, binds ...
12
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti TNFα or anti IL 1 therapies
... (ODF), osteoprotegerin (OPG) ligand (OPGL), and TNF-related activation-induced cytokine ...(TRANCE). RANKL is an essential mediator of bone resorp- tion. RANKL and its natural inhibitor OPG play ...
15
Original Article Expression of osteoprotegerin, RNAK and RANKL genes in femoral head avascular necrosis and related signaling pathway
... challenge. Osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) all regulate the formation of bones via gene transcriptional regulation for the balance between ...
8
Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL
... triad osteoprotegerin (OPG)/receptor activator of NF-kB (RANK)/RANK Ligand (RANKL) is strongly implicated ...by RANKL, a cytokine member of the tumor necrosis factor (TNF) superfamily (TNFSF11) that ...
10
Butyrate Stimulates Histone H3 Acetylation, RANKL Expression, But Inhibited Osteoprotegerin Expression/Secretion in MG-63 Osteoblastic Cells
... containing various concentrations of butyrate (1, 2, 4, 8, 16 mM) for 24 hrs. Cell lysates were collected as described previously using freshly prepared lysis buffer (10 mM Tris-HCl, pH 7; 140 mM sodium chloride; 3 mM ...
35
NF κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony stimulating factor
... CSF, RANKL, OPG, or the sRANKL/OPG ratio may be modu- lated in DHMEQ-treated ...of RANKL and M-CSF by RA-FLS was not enhanced by TNFα, and was not sup- pressed by 10 μg/ml ...express RANKL and M-CSF ...
10
Therapeutic implications of osteoprotegerin
... of RANKL expression leading to loss of the RANKL/OPG-balance, resulting in the oste- oclastogenic proceeds in erosive arthritis ...and RANKL are present in patients with rheumatoid arthritis than in ...
8
Osteoprotegerin in cardiometabolic disorders.
... in RANKL expression. Besides, a higher OPG/RANKL ratio was observed after stimulation with TNF-𝛼 and a decrease in that ratio when cells were stimulated with insulin and ...
17
Bone loss: Factors that regulate osteoclast differentiation an update
... cytokine, osteoprotegerin ligand) have emphasized the crucial role of RANKL, which is expressed by osteoblast/stromal cells, and its receptor RANK, which is expressed by osteoclast cells, in osteo- clast ...
6
The role of osteoprotegerin in arthritis
... of RANKL/RANK interactions other than those involved in osteoclastogenesis, such as the interaction of T cells with dendritic cells ...from RANKL, which has been demonstrated for ...
7
Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model
... Lipopolysaccharides; RANKL: Receptor activator of nuclear factor-kappaB ligand; OPG: Osteoprotegerin; TSBY: Trypticase Soy Broth supplemented with yeast extract; BAP: Blood agar plates; PBS: Phosphate ...
9
Emerging treatments for postmenopausal osteoporosis – focus on denosumab
... and osteoprotegerin (OPG) plays a central role in coupling bone formation and resorp- tion during normal bone turnover and in a wide spectrum of diseases characterized by disturbed bone remodeling, increased bone ...
10
Impact of Smoking on the IL-1Β, IL-8, IL-10, IL-17 and TNF-α Production in Chronic Periodontitis Patients
... Interleukin-17, rankl, osteoprotegerin levels in gingival crevicular fluid from smoker versus non-smoker chronic periodontitis patients during initial periodontal treatme[r] ...
9
Type 2 diabetes affects bone cells precursors and bone turnover
... OPG: Osteoprotegerin; P1NP: Procollagen Type 1 Amino-terminal Propeptide; PBMCs: Peripheral Blood Mononuclear Cells; PE: Phycoerythrin; RANK: Receptor Activator of Nuclear Factor Kappa- Β ; RANKL: Receptor ...
8
Targeting RANKL in metastasis
... by RANKL on RANK-expressing cells in vitro would explain the profound ability of RANKL inhibition to block distant metastasis to nonskeletal sites in ...of RANKL may be due to multiple, pleiotropic ...
8
Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
... important RANKL sheddase in the mouse, perhaps regulated by OPG ...strong RANKL shedding activity in that species, and suppres- sion of MMP-14 in primary mouse osteoblasts increased cell membrane-bound ...
9
RANKL/RANK pathway abrogates cetuximab sensitivity in gastric cancer cells via activation of EGFR and c-Src
... The RANKL activates the EGFR pathway in osteoclasts, and the RANK is expressed in gastric ...the RANKL/RANK pathway has an effect on the EGFR pathway in GC remains ...high-level RANKL expression, and ...
11
Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-κB Pathway
... of RANKL signaling is the activation of NF-κB, which plays a key role in osteoclast diffe- rentiation ...the RANKL-induced osteoclast differentiation effectively both in vitro and in vivo ...the ...
12
Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages
... and RANKL promoted MMP-9 expres- sion and CSE upregulated RANKL expression, we asked whether CSE induction of MMP-9 was dependent or partly through the RANKL ...of RANKL and RANK, creating an ...
11