outer hair cell
Application of force to the cochlear wall: effect on auditory thresholds, outer hair cell transduction, and distortion product otoacoustic emissions
... Good morning, my name is Greg O’Beirne. I’m currently at the Department of Communication Disorders at the University of Canterbury, New Zealand, but this morning I’m going to be talking about the work I have done at the ...
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Helios is a key transcriptional regulator of outer hair cell maturation
... inner hair cells (IHCs) and outer hair cells (OHCs), with OHCs being necessary for sound sensitivity and ...Both cell types are thought to arise from common progenitors, however our ...
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OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67)
... Results: Onset of hearing loss in the investigated ADNSHL family is in childhood, initially affecting the high frequencies and progressing to profound deafness in adulthood. However, there is considerable intrafamilial ...
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Nonlinear cochlear signal processing
... importance of nonlinearity in hearing at low intensities [60, 61]. Ever since Goldstein’s 1967 classic study, distortion product analysis has have been an important experimental tool, which has helped us to understand ...
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The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity
... and outer hair cell (OHC) death in animal ...Whole- cell patch-clamp recordings revealed a significant depolarization of the voltage-operating point of prestin in NPC1- KO mice, suggesting ...
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►▼ Show Figures
... of outer hair cells and the signal level dependent stiffness of the string enables parametric amplification of the input ...nonlinear outer hair cell stiffness change, nonlinear ...
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Nociceptin and the OP4 receptor in the auditory system
... immortomouse cell line at embryonic days 11 and 17 ( E ll and E l 7) was kindly donated by Jean-Marie Chambard from the Department o f Physiology, University College ...Immortomouse cell line is an ...
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Effect of deliberate ingestion of Organophosphate pesticides and snake bites on Distortion product otoacoustic emission (DPOAE)
... of outer hair cells to ototoxic ...the outer hair cell function of normal persons after an accidental exposure to these ototoxic ...for outer hair cell damage of ...
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Original Article Role of Hsp90/Akt pathway in the pathogenesis of gentamicin-induced hearing loss
... inner hair cell (IHCs) nor outer hair cell (OHCs) loss were observed; minimal loss in the basal segment were observed after 16 h of treat- ...Significant hair cell death ...
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Effect of Deliberate Ingestion of Organophosphate Pesticide on Distortion Product Oto Acoustic Emissions (DPOAE)
... produced by the cochlea in response to an acoustic stimulus [12]. A moderate intensity click stimulus or an appropriate combination of two tones can evoke outer hair cell (OHC) motility. This ...
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TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells
... The full molecular identity of the MET channel is still unknown; however, it is possible that the MET channel is not one molecule but a complex that can vary in composition with age and along the tonotopic axis of the ...
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Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata
... supplemented with antibiotics and centrifuged at 430 × g for 10 min (without brakes) to remove contaminating deb- ris and red blood cells. The wash step was repeated 2–3 times depending on the quality of the specimen. ...
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<p>L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes</p>
... Therefore, cell lysates of HHFKs cultivated for 72 h in MGM, IC, in MGM plus the compound L-cystine (Cys: concentration is equal to the L-cystine concentration in IC; 50 µM) and in different L-cystine ...
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Nothing but skin and bone
... Skin and bone — what comes to mind at hearing this phrase? While certainly a metaphor for disease, it also defines two very different tissues, one a flexible and contiguous outer covering, the other a ...
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Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
... planar cell polarity signaling pathway (Kelly and Chen, 2007; Montcouquiol and Kelley, 2003; Montcouquiol et ...which cell intercalations occur and cell-cell junctions appear or disappear ...
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Leaf Anatomy and Morphology in South African Species of Danthonia.
... the outer rows ending in tufts o f longer hairs just below the lobes and the inner rows ending just below the insertion o f the awn; lodicules 2, cuneate, nerved and glabrous; callus ...
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The WEREWOLF MYB protein directly regulates CAPRICE transcription during cell fate specification in the Arabidopsis root epidermis
... position (Galway et al., 1994; Lee and Schiefelbein, 1999; Masucci et al., 1996). WER encodes a putative transcription factor of the MYB family, and it is preferentially expressed in the N-position cells (Lee and ...
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Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
... The hair cells of the organ of Corti within the mammalian cochlea convert mechanical stimuli into receptor ...The hair bundle atop each cell contains multiple rows of stereocilia of increasing ...
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Designer aminoglycosides prevent cochlear hair cell loss and hearing loss
... sensory hair cell ...into hair cells via mechanotransducer channels would reduce ototoxicity, and therefore we synthesized 9 aminoglycosides with modifications based on biophysical properties of the ...
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Hair cells, hearing and hopping: a field guide to hair cell physiology in the frog
... auditory hair cells has been much slower in coming, but has benefited greatly by the overall advances made in the field of vertebrate hair cell ...roles hair cells play in sound detection in ...
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