OXA-48
Evaluation of a New Phenotypic OXA 48 Disk Test for Differentiation of OXA 48 Carbapenemase Producing Enterobacteriaceae Clinical Isolates
... OXA-48 disk test. The test is based on the use of EDTA to permeab- ilize the bacterial cell and release  -lactamases into the external environ- ment. EDTA was also used to inhibit the production of MBL ...
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First Clinical Cases of OXA 48 Producing Carbapenem Resistant Klebsiella pneumoniae in the United States: the “Menace” Arrives in the New World
... for OXA-48 CPE is largely unknown. While an evaluation of 10 OXA-48-producing CPE isolates showed them all as positive by MHT in one study, this may not reflect the sensitivity of the MHT in a ...
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Genomic characterization of Citrobacter freundii strains coproducing OXA-48 and VIM-1 carbapenemase enzymes isolated in leukemic patient in Spain
... Results: Three carbapenem-resistant C. freundii strains (imipenem MIC ≥ 32 mg/L) corresponding to three different AL patients were isolated. Positive modified Carba NP test results suggested carbapenemase production. The ...
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Multi centre evaluation of real time multiplex PCR for detection of carbapenemase genes OXA 48, VIM, IMP, NDM and KPC
... Testing of PCR specificity was carried out on the following strain collection. The test collection of 86 isolates, included 58 carbapenemase producing isolates, and 28 carbapenemase negative controls. The 58 carbape- ...
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Rapid Detection of OXA 48 Producing Enterobacteriaceae by Matrix Assisted Laser Desorption Ionization−Time of Flight Mass Spectrometry
... and OXA-48 confirm kit; Rosco Diagnostica A/S, Taastrup, Denmark) with disks containing meropenem (10 g), mero- penem plus PBA, meropenem plus DPA, meropenem plus cloxa- cillin (CL), and temocillin (30 ...
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Epidemiological and Microbiological Characteristics of an Outbreak Caused by OXA 48 Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Jerusalem, Israel
... he OXA-48 carbapenemase was first discovered in various Enterobacteriaceae species isolated in Turkey and other countries in the Middle East ...of OXA-48-producing Enterobacteriaceae (OPE) ...
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Evaluation of the SpeeDx Carba (beta) multiplex real time PCR assay for detection of NDM, KPC, OXA 48 like, IMP 4 like and VIM carbapenemase genes
... NDM, OXA-48-like, IMP-4-like, and VIM carbapenemase-encoding genes in a single multiplex ...NDM-1-7; OXA-48, 162, 163, 181, 204, 232, 244, 245, 247, 370; and IMP-1, 2, 4, 6, 8, 10, 13, 18, 19, ...
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Dissemination of Carbapenem resistant Klebsiella pneumoniae clinical isolates with various combinations of Carbapenemases (KPC 2, NDM 1, NDM 4, and OXA 48) and 16S rRNA Methylases (RmtB and RmtC) in Vietnam
... was not reported (the second structure from the bottom in Fig. 1), whereas the other was identical with plasmids in OXA-48 producing K. pneumoniae strains 153,877–1 in Netherlands (GenBank accession no. ...
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Evaluation of a DNA Microarray (Check MDR CT102) for Rapid Detection of TEM, SHV, and CTX M Extended Spectrum β Lactamases and of KPC, OXA 48, VIM, IMP, and NDM 1 Carbapenemases
... FIG. 1. Typical DNA microarray pictures obtained with the Check-MDR CT102 microarray setup. This format uses a DNA microarray fixed at the bottom of a microreaction vial. The microarray consists of unique complementary ...
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Emerging Carbapenem Resistant Enterobacter cloacae Producing OXA 48 , VIM and IMP Type β Lactamases in Eastern Cape Hospitals in South Africa
... Carbapenem non-susceptible enterobacteriaceae isolates were submitted to the Antimicrobial Resistance Labo- ratory at the National Institute for Communicable Diseases for confirmation of carbapenemase-producing en- ...
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Clinical Performance of Check Direct CPE, a Multiplex PCR for Direct Detection of bla KPC, bla NDM and/or bla VIM, and bla OXA 48 from Perirectal Swabs
... (Table 2 and Fig. 1). Additionally, only 56% (n ⫽ 19) of the false- positive specimens grew organisms on culture even when plated onto less-selective media (including enrichment broth). Huang et al. reported a similar ...
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Plasmid mediated colistin resistant mcr-1 and co-existence of OXA-48 among Escherichia coli from clinical and poultry isolates: first report from Nepal
... for OXA-48 genes using conventional Polymerase chain reaction ...gene, OXA-48, among colistin resistant mcr-1 positive isolates was 38% (8/21) in poultry speci- mens and ...
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<p>Detection of OXA-48 Gene in Carbapenem-Resistant <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em> from Urine Samples</p>
... AMR, including MDR, is a global issue. Its impact varies among different countries, with a relatively high burden in developing countries. 46 Moreover, multidrug-resistant patho- gens are often dif fi cult to treat and ...
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OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
... of OXA-48 resistance toward CAZ/CAZ-AVI conferred collateral sensitivity where the car- bapenem and penicillin activities of the enzyme were ...reported OXA-48-like variants (OXA-163, ...
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Rapid Identification of OXA 48 and OXA 163 Subfamilies in Carbapenem Resistant Gram Negative Bacilli with a Novel Immunochromatographic Lateral Flow Assay
... pneumoniae OXA-232 isolate and one Escherichia coli OXA- 242 isolate ...as OXA-48 positive and OXA-163 negative, as explained ...the OXA-163 test line was observed for all 33 ...
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Multiplex Immunochromatographic Detection of OXA 48, KPC, and NDM Carbapenemases: Impact of Inoculum, Antibiotics, and Agar
... This study demonstrates that the ICT is an excellent test for the detection of OXA-48-like, KPC, and NDM carbapenemases. However, in contrast to previous studies, we demonstrated that the performance ...
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The spread of bla OXA-48 and bla OXA-244 carbapenemase genes among Klebsiella pneumoniae, Proteus mirabilis and Enterobacter spp. isolated in Moscow, Russia
... bla OXA-48-like genes were detected only after four and 18 months after the research start, ...bla OXA-48-like gene acquisition was shown for ...bla OXA-48-like -positive K. ...
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Antibiotic Resistance Patterns and Detection of OXA-23 and OXA-48 Genes in Acinetobacter baumannii Isolated from Ventilator Associated Pneumonia
... (OXA). OXA-23 is one of the most common OXA enzymes in ...Also, OXA-48 is one of the OXA types in this bacterium with high carbapenemase activity ...
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Proof-of-concept trial of the combination of lactitol with Bifidobacterium bifidum and Lactobacillus acidophilus for the eradication of intestinal OXA-48-producing Enterobacteriaceae
... on OXA-PE selective agar media (chromID ™ OXA-48, bioMérieux), and tryptic soy broth containing an ertapenem disk (1 µg/ml), and incubated for 18 h at 37 ...bla OXA-48 ...
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Detection of Pan drug resistance OXA-48 producing Providencia in an ICU patient for the first time in Nepal
... an OXA-48 drug resistance pattern observed in blood and urinary isolates of Providencia species in a fatal meningoencephalitis case who subsequently de- veloped ventilator associated pneumonia and urinary ...
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