oxygen-induced retinopathy
Fully automated, deep learning segmentation of oxygen-induced retinopathy images
... of oxygen-induced retinopathy (OIR) is one of the most commonly used rodent models to study ischemia-driven abnormal neovessel formation and retinal vasoproliferative disease ...75% oxygen, ...
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Mast cell hyperactivity underpins the development of oxygen induced retinopathy
... of oxygen-induced retinopathy ...early retinopathy of prematurity had markedly higher plasma MCT levels than age-matched infants without disease, suggesting mast cells contribute to human ...
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Original Article Celecoxib attenuates retinal angiogenesis in a mouse model of oxygen-induced retinopathy
... of oxygen-induced retinopathy (OIR) that is a generally used meth- od to observe the retinal microvascular compli- cations in retinopathy of prematurity and dia- betic retinopathy to ...
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The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway
... Methods: The oxygen-induced retinopathy (OIR) model was established in C57BL/6J mice exposed to a high concentration of oxygen. Retinas were obtained from the normoxia, OIR, OIR control ...
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Original Article Anti-angiogenic effect of rapamycin in mouse oxygen-induced retinopathy is mediated through suppression of HIF-1alpha/VEGF pathway
... Abstract: Hypoxia-inducible factor-1alpha (HIF-1α)-vascular endothelial growth factor (VEGF) pathway, a downstream of mammalian target of rapamycin (mTOR), plays a major role in the formation of pathological retinal ...
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Original Article Role of hypoxia-inducible factor-1α and survivin in oxygen-induced retinopathy in mice
... of oxygen-induced retinopathy (OIR) was induced in C57BL/6 mice by exposing 75% oxygen from postnatal day 7 (p7) to p12 and then followed by room ...retina oxygen-induced ...
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The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model
... The effect of tocopherol (vitalnin E) on oxygen- induced retinopathy was studied in 75 kittens following the development of a 12-point scoring systenl to quantitate the.. degree of retin[r] ...
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Targeting VEGF in canine oxygen-induced retinopathy - a model for human retinopathy of prematurity
... 15-day-old oxygen-treated animal immunostained with anti-vWf (A and D), anti-KDr (VEgFr2) antibody that was preincubated overnight with phosphate buffered saline (B and E), or anti-KDr antibody preincubated ...
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Revisiting the mouse model of oxygen-induced retinopathy
... Notes: in this composite image, retinal flatmounts from C57Bl/6 mice at P17 under normal (left) and OiR (right) conditions were stained with isolectin B4 to label the vasculature (white). Normally, as seen on the left, ...
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Inhibitory effect of Samul tang on retinal neovascularization in oxygen induced retinopathy
... Samul-tang (SMT), which is known as Shimotsu-to in Japanese and Si-Wu decoction in Chinese, is a basic prescription that consists of four herbs. For hundreds of years in Eastern Asia, SMT has been a traditional treat- ...
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Original Article Temporal and spatial expression change of GPR124 in mouse retinal development and in oxygen-induced retinopathy model
... Abstract: G protein-coupled receptor 124 (GPR124), a member of the class II GPR family, is up-regulated in endo- thelial cells during central nervous system and tumor angiogenesis. However, the expression change of ...
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Anti-VEGF therapy in the management of retinopathy of prematurity: what we learn from representative animal models of oxygen-induced retinopathy
... Abstract: Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness, affecting infants born ...of oxygen-induced retinopathy (OIR), highlighting the importance of VEGF ...
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Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) model
... suspended vascular development and vaso-obliteration leading to severe retinal stress and hypoxia. We tested the hypothesis that the use of the human progenitor cell combination, bone marrow–derived CD34 + cells and ...
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Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy
... (oxygen-induced retinopathy) mouse model, normal vascular development is interrupted when mice are being placed in hyperoxia (75% oxygen) from P7 to ...
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Effects of Marginal Hypoxemia on Recovery from Oxygen-Induced Retinopathy in the Kitten Model
... One current theory regarding the etiology of ROP in human premature infants is that the cicatricial sequelae follow (for unknown reasons) an acute vascular retinopathy that develops in r[r] ...
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Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice
... UNC5B promoted or inhibited retinal neovasculariza- tion of OIR mice was still unknown. To further investi- gate the role of UNC5B in retinal neovascularization, we observed the effects of inhibition of retinal ...
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Oxygen-Induced Retinopathy in Newborn Rats: Effects of Prolonged Normobaric and Hyperbaric Oxygen Supplementation
... All 16 rats from the two litters of group 1 (treated with normobaric 80% 02 for five days followed by room air for five more days) had tortuous, congested retinal vessels with significan[r] ...
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Animal models of diabetic retinopathy: doors to investigate pathogenesis and potential therapeutics
... In mice, rats, and dogs, oxygen-induced retinopathy (OIR) models are widely utilized for the investigation of retinal neovascularization [47-50]. Although these models do not show hyperglycemia, it ...
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Choosing preclinical study models of diabetic retinopathy: key problems for consideration
... Experimentally, mice and rats are still the most popular models of DR, not only because of the advantages mentioned above, but also since there have been many standardized protocols of modeling approaches available for ...
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Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice
... of oxygen-induced retinopathy (OIR) to simulate the occur- rence of ROP, which was induced by hyperoxia, to observe the expressions of Smo and Gli1, as well as key factors in the Hedgehog ...
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