Oxygen-induced retinopathy model
Original Article Temporal and spatial expression change of GPR124 in mouse retinal development and in oxygen-induced retinopathy model
... played a significant role in the central nervous system (CNS) angiogenesis [9-11]. Various studies have determined that GPR124 was expressed in endothelial cells and pericytes during mouse embryogenesis, most prominent- ...
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Choosing preclinical study models of diabetic retinopathy: key problems for consideration
... STZ-injection model, oxygen- induced retinopathy model, and genetic ...DR model, for eg, the experimental methods of STZ injection, 63 high-glucose diet ...
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Original Article Role of hypoxia-inducible factor-1α and survivin in oxygen-induced retinopathy in mice
... The model of oxygen-induced retinopathy (OIR) was induced in C57BL/6 mice by exposing 75% oxygen from postnatal day 7 (p7) to p12 and then followed by room ...retina ...
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Fully automated, deep learning segmentation of oxygen-induced retinopathy images
... The described pipeline may also open the door to simultaneously look at more readout parameters and detect more subtle changes in this model. For example, Fruttiger and colleagues suggested using vascular ...
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Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) model
... the DVP with incorporation of the human ECFCs into the DVP observed by P12 (Figure 4). During normal retinal development, the DVP is complete in mice by approximately P12. However, in C57BL/6 OIR mice, formation of the ...
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Mast cell hyperactivity underpins the development of oxygen induced retinopathy
... OIR model and that cromolyn completely blocked its expression (Figure ...not induced in the retina of OIR mice (data not ...MCP1 induced capillary tube formation comparable to that of mMCP6 (Figure ...
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Inhibitory effect of Samul tang on retinal neovascularization in oxygen induced retinopathy
... proliferative retinopathy and retinopathy of prematurity ...diabetic retinopathy and retinop- athy of prematurity [33, ...is induced by SDF-1/ CXCR4 activation in several cell ...vivo ...
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Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice
... In mammals, receptors of netrin-1 include the DCC family (deleted in colorectal cancers) and the UNC5 ho- mologs. Together, the receptors include DCC, neogenin, UNC5A, UNC5B, UNC5C, and UNC5D. A2b was also re- ported to ...
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Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy
... One of the best-known mediators released by micro- glial cells is TNF (TNF-alpha). TNF is significantly upre- gulated during the hypoxic stages of OIR [7]. During the earlier, hypoxic stages of the OIR model, TNF ...
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Revisiting the mouse model of oxygen-induced retinopathy
... as retinopathy of prematurity (ROP), proliferative diabetic retinopathy, and the wet form of age-related macular ...supplemental oxygen therapy for premature neonates more than 70 years ...mouse ...
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The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt–VEGF signaling pathway
... Methods: The oxygen-induced retinopathy (OIR) model was established in C57BL/6J mice exposed to a high concentration of oxygen. Retinas were obtained from the normoxia, OIR, OIR control ...
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Animal models of diabetic retinopathy: doors to investigate pathogenesis and potential therapeutics
... dogs, oxygen-induced retinopathy (OIR) models are widely utilized for the investigation of retinal neovascularization ...animal model using this concept in ...this model, researchers ...
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Knockout of insulin and IGF 1 receptors on vascular endothelial cells protects against retinal neovascularization
... guidelines. Oxygen-induced retinopathy was induced in newborn mice according to the protocol of Smith et ...of oxygen was raised to 75% and maintained for 5 days (P12), after which they ...
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Anti-VEGF therapy in the management of retinopathy of prematurity: what we learn from representative animal models of oxygen-induced retinopathy
... mouse model of OIR, in response to hypoxia, β -AR isoforms expressed differently with upregulation of β 3-AR in the retina at p17 when neovascular tufts develop, while the expression of β 1-AR and β 2-AR in the ...
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Original Article Celecoxib attenuates retinal angiogenesis in a mouse model of oxygen-induced retinopathy
... OIR model was consis- tent with that described by Smith et al ...3% oxygen) for 5 days (P7 to P 11) and then removed into normoxic condition for an addi- tional 5 days (P12 to ...and oxygen levels ...
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The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model
... The effect of tocopherol (vitalnin E) on oxygen- induced retinopathy was studied in 75 kittens following the development of a 12-point scoring systenl to quantitate the.. degree of retin[r] ...
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Targeting VEGF in canine oxygen-induced retinopathy - a model for human retinopathy of prematurity
... Canine oxygen-induced retinopathy (OIR) was first developed by Arnall Patz in an effort to experimentally determine the effects of hyperoxia on the development of the retinal ...OIR model has ...
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Expression and significance of the Hedgehog signal transduction pathway in oxygen-induced retinal neovascularization in mice
... mouse model of oxygen-induced retinopathy (OIR) to simulate the occur- rence of ROP, which was induced by hyperoxia, to observe the expressions of Smo and Gli1, as well as key factors ...
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Effects of Marginal Hypoxemia on Recovery from Oxygen-Induced Retinopathy in the Kitten Model
... One current theory regarding the etiology of ROP in human premature infants is that the cicatricial sequelae follow (for unknown reasons) an acute vascular retinopathy that develops in r[r] ...
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A study on role of thrombocytopenia in retinopathy of prematurity
... Posterior Retinopathy of Prematurity (APROP) with similar stage and plus disease as the index case, the mean platelet count before laser treatment was compared with 21 age- and birth weight-matched control ...
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