P2X Receptors
Genomic Organization of Purinergic P2X Receptors
... Purinergic P2X receptors are a family of ligand-gated cationic channels activated by extracellular ...ATP. P2X subunit protein sequences are highly conserved between vertebrate ...in P2X ...
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Molecular and cellular mechanisms of nociception in equine laminitis: purinergic P2X receptors expression and distribution
... P2X receptor expression and function in peripheral nerve has been extensively studied in other species (for review see Dunn et al. 2001) and P2X2 and P2X3 receptor subtype immunoreactivity has been documented in ...
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Nociceptive transmission and modulation via P2X receptors in central pain syndrome
... channel P2X receptors, in central nervous system pain transmission and persistent modulation upon and following the occurrence of neuropathic ...Several P2X receptor subtypes, including P2X2, P2X3, ...
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Purinergic signalling: Sensitisation of recombinant P2X receptors
... transmission process'" (Burnstock, 1976). In an attempt to assign neurotransmitter status, techniques such as classical organ-bath pharmacology (identifying and characterising receptor subtypes) and binding studies ...
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Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
... Purinergic receptors participate, in almost every cell type, in controlling metabolic activities and many physiological functions including signal transmission, proliferation and ...P2Y receptors induce ...
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SEVERAL P2X RECEPTOR ANTAGONISTS, INCLUDING NF279 AND PPADS SUPPRESS GABA RESPONSES IN ISOLATED HIPPOCAMPAL NEURONS.
... of P2X-receptors suramin on currents evoked by exogenous GABA application (GABA-currents), we studied effects of two other antagonists NF279 (8,8'- ...
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Localization of P2X receptor subtypes 2, 3 and 7 in human urinary bladder
... the muscle layer. This observation was confirmed by the low correlation between vimentin and P2X7 immunore- activity in the smooth muscle layer of the human urinary bladder (Fig. 1c-d). By calculating the Pearson´s ...
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Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia
... P2X1 and P2X7 effects. In our studies, we found no effects of hypoxia or nucleotides on P2X1 receptor mRNA in normoxia; however, P2X1 receptor expression in hypoxia was negatively correlated with the P2X ...
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Current and emerging “at-site” pain medications: a review
... purinergic receptors P1 and P2. The P1 receptors are known as adenosine receptors, whereas P2 receptors are further divided into P2Y (G-protein coupled receptors) and P2X ...
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The P2X receptor mediated regulation of inhibitory synaptic transmission
... postsynaptic receptors via a calcium dependent process as a result of their high calcium ...of P2X receptors is their capacity to interact with other receptors involved in ...acetylcholine ...
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A study of the distribution and function of P2 receptors during chick embryogenesis
... these P2X receptors. P2X ion channels exhibit little selectivity for monovalent cations, but under physiological conditions Na'^ is the predominant depolarizing ion (Benham, 1989; Evans et ...of ...
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Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and their Roles in Extracellular Nucleotide Regulation of Cell Functions.
... P2 receptors on the cell surface, which represents one of the most common signalling ...P2 receptors comprise ligand-gated ion channel P2X receptors and G-protein-coupled P2Y ...the P2X ...
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P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes
... associated with an opening of distinct ATP-gated channels and not with any “dilation” of the P2X receptors. The current–voltage relationships for both types of ATP-induced currents were linear, with a ...
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ATP and ATP receptors in human dental pulp
... The number of PlXg-ir neurons observed in the odontoblastic layer, suggests that ATP and its receptors are involved in signal transduction at the pulp-dentine border. It is known that most stimuli applied to ...
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Adenovirus Receptors
... vitronectin receptors ␣ v  3 and ␣ v  5 (100), as well as ␣ v  1 (44), ␣ 3  1 (70), and ␣ 5  1 (19), all of which recognize RGD ...primary receptors (52, 75), and—with the exception of the subgroup F ...
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P2X Antagonists Inhibit HIV-1 Productive Infection and Inflammatory Cytokines Interleukin-10 (IL-10) and IL-1β in a Human Tonsil Explant Model
... two P2X antagonists, NF449 (a P2X1 to P2X7 inhibitor) and A438079 (a P2X7 inhibitor), would reduce HIV-1 productive infection in comparison to treatment with ...
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P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice
... receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (decryption) of TF procoagulant activity and promoted release of TF + MPs from macrophages and ...
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Importance of innate mucosal immunity and the promises it holds
... Pyrin domain-containing NOD-like receptors play a key role in the regulation of caspase-1 by forming a multiprotein complex known as the “inflammasome”. Caspase-1 partici- pates in the processing and subsequent ...
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016_2009.pdf
... coupled receptors (GPCRs) known as ‘Receptors Activated Solely by Synthetic Ligands (RASSLs),’ and ‘Designer Receptors Exclusively Activated by a Designer Drug ...these receptors is not ...
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Deregulation of innate and adaptive immune responses in human papillomavirus infection and cancer
... recognition receptors that allow infected cells to attract the immune system, undifferentiated keratinocytes (KCs) are the main targets for latent infection with high-risk human papilloma viruses ...virus-sensing ...
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