P2X7 receptor
Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies
... The P2X7 receptor (P2X7R) is important in medi- ating a range of physiological functions and pathologies asso- ciated with tissue damage and inflammation and represents an attractive therapeutic ...the ...
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Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain
... Background: Despite substantial progress, pathogenesis and therapy of chronic pain are still the focus of many investigations. The ATP-gated P2X7 receptor (P2X7R) has previously been shown to play a central ...
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Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome
... The P2X7 receptor is found on many cells and tissues throughout the ...The receptor is most highly expressed on cells of the macrophage lineage, including dendritic cells and microglia [13,16], and ...
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Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors
... Fig. 6 P2X7 receptor agonist administration induces depressive-like behaviors. a – f ATP or BzATP causes depressive-like behaviors which are the same as chronic unpredictable stress (CUS). a Experimental ...
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Anti allodynic effect of intrathecal processed Aconitum jaluense is associated with the inhibition of microglial activation and P2X7 receptor expression in spinal cord
... purinergic receptor expression in dorsal root ganglion neurons in rats with neuropathic ...ATP-induced P2X7 receptor (P2X7R)-mediated inflammatory responses in microglial cell ...
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The P2X7 receptor–pannexin 1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice
... Pannexin-1 (Panx1) plays a role in the release of ATP and glutamate in neurons and astrocytes. Panx1 can be opened at the resting membrane potential by extracellular ATP via the P2X7 receptor (P2X7R). Panx1 ...
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Role of the P2X7 receptor in the osteogenic differentiation of mesenchymal cells and in osteoclast fusion
... interesting concept, and one that might not be restricted just to MSC cells. Indeed, cells within the bone itself, osteoblasts and osteoclasts have long been known to express the P2X7 receptor [10-12]. ...
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Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives
... from P2X7-/- ...full-length P2X7, monitored by both western blotting and immunohistochemistry, was decreased compared to the normal ...of P2X7 as compared to normal ...of P2X7 with BzATP could ...
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P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus
... BzATP. P2X7 receptor expression is increased in the rat hippocampus following pilocarpine-induced SE ...full P2X7 receptor ...of P2X7 receptor agonists and antagonists to alter ...
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Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus
... ANOVA: analysis of variance; BBG: Brilliant blue G; BzATP: 2 ′ , 3 ′ -O-(4-benzoyl- benzoyl)adenosine5 ′ -triphosphate; CBF: cerebral blood flow; CCAs: common carotid arteries; CNS: central nervous system; GAPHD: ...
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P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus
... that P2X7 receptor-mediated leukocyte infiltration (particu- larly neutrophil infiltration) may be a crucial factor in neuronal damage in the FPC following ...
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P2X7 receptor mediates NLRP3 dependent IL 1β secretion and parasite proliferation in Toxoplasma gondii infected human small intestinal epithelial cells
... Control FHs 74 Int cells or siRNA-transfected FHs 74 Int cells were mock-infected or infected with the T. gondii GFP-RH strain as indicated. After the cells were washed with ice-cold PBS, proteins were extracted with ...
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Original Article A promising independent prognostic biomarker in colorectal cancer: P2X7 receptor
... The P2X7 receptor (P2X7R) is an exclusive member of the purinergic receptor family that plays a key role in tumor progression, including colorectal cancer ...
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Functional variant of the P2X7 receptor gene is associated with human papillomavirus-16 positive cervical squamous cell carcinoma
... human P2X7 receptor gene (P2RX7) contains 13 exons and is mapped to the 12q24 chromosomal region ...affect receptor function [18]. Given the crucial role of P2X7 receptor in immune ...
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Genetic background strongly influences the bone phenotype of P2X7 receptor knockout mice
... the P2X7 receptor in the regulation of the skeletal system, the bone phenotype of two mouse models with ablation of the P2X7 receptor was examined [13, 22, ...The P2X7 knock-out model ...
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Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists
... and 22 mM glucose, pH 7.3. Cells were washed with assay buffer and incubated at 37 ° C for 20 min with 80 l l of assay buffer con- taining 1 l M YO-PRO-1 with either DMSO or the test compound. Cells were excited at 485 ...
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New insights of P2X7 receptor signaling pathway in alveolar functions
... Purinergic P2X7 receptor (P2X7R), an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory ...purinergic ...
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The P2X7 receptor is an important regulator of extracellular ATP levels
... The P2X7 receptor is distinct from other P2X receptors in that it has a relatively low sensitivity for ATP (>100 μM) and pref- erentially binds to 2 ,3 -O-(benzoyl-4-benzoyl)-ATP ...of P2X7 ...
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P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice
... 0.001). P2X7 receptor sig- naling also triggers the release of the proinflammatory cytokine ...the P2X7 receptor–dependent release of inflammatory cytokines and ...
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Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma
... The P2X7 receptor (P2X7R) is attracting increasing attention for its involvement in ...both. Receptor expression was a powerful stimulus for cell growth, the most efficient growth-promoting isoform ...
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